Article
Genetics & Heredity
Ye Lin Son, Kwang Pak, Nada Muradagha, Kyung Wook Heo, Anke Leichtle, Arwa Kurabi
Summary: This study describes the first use of humanized mice to study otitis media (OM). The results demonstrate that humanized mice with sufficient engraftment can recapitulate a normal middle ear inflammatory response and exhibit normal recovery. This model has many potential uses in OM research.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Xiaolei Liu, Li Li, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang
Summary: A new humanized anti-IL-6 mAb HZ-0408b with potent binding and neutralizing activity to human IL-6 has been developed. It showed a high species specificity and lower cross-reactivity compared to other anti-IL-6 mAbs. HZ-0408b exhibited a stronger inhibitory effect on IL-6 signaling and effectively reduced joint swelling and plasma CRP levels in a monkey CIA model.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rui Hu, Tao Yuan, Hui Wang, Jianglin Zhao, Liya Shi, Quankai Li, Chunmei Zhu, Na Su, Shengzhao Zhang
Summary: This meta-analysis found that etanercept biosimilars were more effective than reference biologics (Enbrel) in terms of ACR50 response rate for treating active rheumatoid arthritis, while other outcomes related to efficacy, safety, and immunogenicity were comparable between etanercept biosimilars and the originator.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Li Lin, Weixia Xuan, David Luckey, Shaohua Wang, FaPing Wang, Jessica Lau, Kenneth J. Warrington, Eric L. Matteson, Robert Vassallo, Veena Taneja
Summary: Smoking has been linked to the pathogenesis of seropositive rheumatoid arthritis (RA) and RA-associated lung disease. In arthritis-susceptible mice exposed to cigarette smoke and bleomycin, a combined pattern of fibrosis and emphysema was observed. This humanized mouse model can be a valuable research tool for understanding RA associated lung disease.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Audrey Paoletti, Bineta Ly, Samuel Bitoun, Gaetane Nocturne, Elodie Riviere, Jessica J. Manson, Andrea Matucci, Marc Pallardy, Niek De Vries, Xavier Mariette
Summary: This longitudinal study demonstrates that ADA but not ETA is able to restore the M2-like polarization of monocytes that is defective in RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Janet Pope, Stephen Hall, Claire Bombardier, Boulos Haraoui, Graeme Jones, Latha Naik, Carol J. Etzel, Dena R. Ramey, Ricardo Infante, Maia Miguelez, Stephanie Falcao, Sevag Sahakian, David Wu
Summary: This study evaluated the effectiveness of the voluntary switch from originator (etanercept, ETN) to etanercept biosimilar (SB4) in patients with stable rheumatoid arthritis (RA). The results showed that SB4 demonstrated comparable effectiveness to ETN in patients with stable RA who voluntarily switched to the biosimilar in a real-world setting.
ADVANCES IN THERAPY
(2022)
Article
Rheumatology
Rehab Mahmoud Salem, A. E. El-deeb, Mervat Elsergany, Hanan Elsaadany, Radwa M. El-khouly
Summary: The study evaluated the safety and efficacy of intra-articular injection of etanercept compared to corticosteroid injection in RA patients. Etanercept showed better results in joint pain scores in the short term, while corticosteroids had more sustained effects. No major side effects were observed with intra-articular injection of etanercept.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Zahra Bagheri-Hosseinabadi, Alireza Dehghani, Mohammad Amin Lotfi, Mitra Abbasifard
Summary: This study evaluated the effect of drug treatment on the risk of COVID-19 infection in patients with rheumatoid arthritis (RA). It was found that RA patients receiving Etanercept had an increased risk of COVID-19. Additionally, the study found that the use of Etanercept in RA patients lowered serum levels of TNF-α, IL-1β, and IL-6.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Marie F. Hemon, Nathalie C. Lambert, Jean Roudier, Isabelle Auger
Summary: Rheumatoid arthritis (RA) is often preceded by the emergence of anti-citrullinated protein autoantibodies (ACPAs). This study found that mice expressing the RA-associated HLA-DRB1 alleles were more sensitive to PAD2 immunization and produced higher levels of anti-citrullinated peptide antibodies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Omar Al Tabaa, Adrien Etcheto, Sophie Dumas, Frederic Batteux, Claire Goulvestre, Anna Molto, Corinne Miceli-Richard, Maxime Dougados
Summary: This study aimed to describe the switch from iETN to bETN, evaluate factors associated with the switch, and assess the efficacy of the switch. Findings suggest that physician age and position may influence the likelihood of patients switching to bETN. After 6 months of follow-up, the bETN retention rate was 83%.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Mingcai Wu, Mengjun Tao, Quanhai Wang, Xiaohua Lu, Hui Yuan
Summary: Through network meta-analysis, the study found that the combination therapy of ETN and MTX may have the best efficacy, outperforming other drugs. Compared to placebo, ETN, ETN + MTX, and ANA were also effective in treating RA.
Article
Rheumatology
Eugen Feist, Xenofon Baraliakos, Frank Behrens, Diamant Thaci, Thilo Klopsch, Anja Plenske, Lisa K. Blindzellner, Pascal Klaus, Thomas Meng, Peter-Andreas Loeschmann
Summary: This study investigated the proportion of German patients with rheumatoid arthritis who achieved remission or low disease activity after 12 and 24 weeks of etanercept treatment. It found that a considerable proportion of patients attained their treatment targets after 12 weeks, and the proportion further increased with longer treatment duration.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Farhad Gharibdoost, Amir-Hossein Salari, Mansour Salesi, Faegheh Ebrahimi Chaharom, Peyman Mottaghi, Mansour Hosseini, Maryam Sahebari, Mohammadali Nazarinia, Zahra Mirfeizi, Mohammadreza Shakibi, Hamidreza Moussavi, Mansour Karimifar, Karim Mowla, Hadi Karimzadeh, Nassim Anjidani, Ahmadreza Jamshidi
Summary: This study aimed to evaluate the safety and effectiveness of biosimilar etanercept in patients with RA, AS, and PsA. The results demonstrated the real-world safety and effectiveness of biosimilar etanercept in patients with RA, PsA, and AS.
ADVANCES IN THERAPY
(2021)
Article
Instruments & Instrumentation
Abhirami Thumsi, Srivatsan J. J. Swaminathan, Joslyn L. L. Mangal, Abhirami P. P. Suresh, Abhinav P. P. Acharya
Summary: The reprogramming of immune cells' metabolism can improve their function and reduce the severity of autoimmune diseases. In this study, a rheumatoid arthritis (RA) mouse model was developed to mimic immune flare-ups. The use of immune metabolic modulator paKG(PFK15 + bc2) microparticles (MPs) effectively reduced clinical symptoms of RA in mice.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Medicine, General & Internal
Bruna O. Ascef, Matheus O. Almeida, Ana Cristina de Medeiros Ribeiro, Danieli C. O. Andrade, Haliton A. de Oliveira Junior, Tiago Pereira, Patricia C. de Soarez
Summary: This study aims to evaluate the efficacy and safety of biosimilars compared to biologics for rheumatoid arthritis patients, as well as the impact of switching between the two on patient management. Through a systematic review, conclusions regarding clinical outcomes and equivalence of substituting biosimilars for biologics in the treatment of RA will be obtained.
SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Alexander V. Misharin, Luisa Morales-Nebreda, Paul A. Reyfman, Carla M. Cuda, James M. Walter, Alexandra C. McQuattie-Pimentel, Ching-I Chen, Kishore R. Anekalla, Nikita Joshi, Kinola J. N. Williams, Hiam Abdala-Valencia, Tyrone J. Yacoub, Monica Chi, Stephen Chiu, Francisco J. Gonzalez-Gonzalez, Khalilah Gates, Anna P. Lam, Trevor T. Nicholson, Philip J. Homan, Saul Soberanes, Salina Dominguez, Vince K. Morgan, Rana Saber, Alexander Shaffer, Monique Hinchcliff, Stacy A. Marshall, Ankit Bharat, Sergejs Berdnikovs, Sangeeta M. Bhorade, Elizabeth T. Bartom, Richard I. Morimoto, William E. Balch, Jacob I. Sznajder, Navdeep S. Chandel, Gokhan M. Mutlu, Manu Jain, Cara J. Gottardi, Benjamin D. Singer, Karen M. Ridge, Neda Bagheri, Ali Shilatifard, G. R. Scott Budinger, Harris Perlman
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Editorial Material
Critical Care Medicine
Alexander V. Misharin, G. R. Scott Budinger
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Immunology
Bria M. Coates, Kelly L. Staricha, Clarissa M. Koch, Yuan Cheng, Dale K. Shumaker, G. R. Scott Budinger, Harris Perlman, Alexander V. Misharin, Karen M. Ridge
JOURNAL OF IMMUNOLOGY
(2018)
Article
Critical Care Medicine
James M. Walter, Ziyou Ren, Tyrone Yacoub, Paul A. Reyfman, Raj D. Shah, Hiam Abdala-Valencia, Kiwon Nam, Vince K. Morgan, Kishore R. Anekalla, Nikita Joshi, Alexandra C. McQuattie-Pimentel, Ching-I Chen, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, Saul Soberanes, Raul P. Aillon, Satoshi Watanabe, Kinola J. N. Williams, Ziyan Lu, Joseph Paonessa, Peter Hountras, Madonna Breganio, Nicole Borkowski, Helen K. Donnelly, Jonathan P. Allen, Luis A. Amaral, Ankit Bharat, Alexander V. Misharin, Neda Bagheri, Alan R. Hauser, G. R. Scott Budinger, Richard G. Wunderink
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Paul A. Reyfman, James M. Walter, Nikita Joshi, Kishore R. Anekalla, Alexandra C. McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching- Chen, Ziyou Ren, Rohan Verma, Hiam Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, Saul Soberanes, Satoshi Watanabe, Kinola J. N. Williams, Annette S. Flozak, Trevor T. Nicholson, Vince K. Morgan, Deborah R. Winter, Monique Hinchcliff, Cara L. Hrusch, Robert D. Guzy, Catherine A. Bonham, Anne Sperling, Remzi Bag, Robert B. Hamanaka, Gokhan M. Mutlu, Anjana Yeldandi, Stacy A. Marshall, Ali Shilatifard, Luis A. N. Amaral, Harris Perlman, Jacob Sznajder, A. Christine Argento, Colin T. Gillespie, Jane Dematte, Manu Jain, Benjamin D. Singer, Karen M. Ridge, Anna P. Lam, Ankit Bharat, Sangeeta M. Bhorade, Cara J. Gottardi, G. R. Scott Budinger, Alexander Misharin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Editorial Material
Respiratory System
Nikita Joshi, Satoshi Watanabe, Rohan Verma, Renea P. Jablonski, Ching-I Chen, Paul Cheresh, Nikolay S. Markov, Paul A. Reyfman, Alexandra C. McQuattie-Pimentel, Lango Sichizya, Ziyan Lu, Raul Piseaux-Aillon, David Kirchenbuechler, Annette S. Flozak, Cara J. Gottardi, Carla M. Cuda, Harris Perlman, Manu Jain, David W. Kamp, G. R. Scott Budinger, Alexander V. Misharin
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Medicine, Research & Experimental
Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G. N. Garcia, Alexander Misharin, Karen M. Ridge, G. R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob Sznajder
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Editorial Material
Critical Care Medicine
Oliver Eickelberg, Alexander V. Misharin, Patricia J. Sime
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Hanh Chi Do-Umehara, Cong Chen, Qiao Zhang, Alexander Misharin, Hiam Abdala-Valencia, S. Marina Casalino-Matsuda, Paul A. Reyfman, Kishore R. Anekalla, Francisco J. Gonzalez-Gonzalez, Marc A. Sala, Chao Peng, Ping Wu, Catherine C. L. Wong, Ravi Kalhan, Ankit Bharat, Harris Perlman, Karen M. Ridge, Jacob Sznajder, Peter H. S. Sporn, Navdeep S. Chandel, Jindan Yu, Xiangdong Fu, Irina Petrache, Rubin Tuder, G. R. Scott Budinger, Jing Liu
Article
Multidisciplinary Sciences
Qi-Quan Huang, Renee Doyle, Shang-Yang Chen, Qicong Sheng, Alexander Misharin, Qinwen Mao, Deborah R. Winter, Richard M. Pope
Summary: Analysis of a novel mouse model of rheumatoid arthritis reveals the importance of the macrophage tissue-resident niche in suppressing chronic inflammation, potentially contributing to the pathogenesis of rheumatoid arthritis.
Article
Medicine, Research & Experimental
Abhineet M. Sharma, Robert Birkett, Erika T. Lin, Linda M. Ernst, William A. Grobman, Suchitra Swaminathan, Hiam Abdala-Valencia, Alexander Misharin, Elizabeth T. Bartom, Karen K. Mestan
Summary: Placental lesions are associated with unique changes in gene expression in fetal monocytes and monocyte subsets. Fetal monocytes exposed to acute placental inflammation upregulate biological processes related to monocyte activation, monocyte chemotaxis, and platelet function, while monocytes exposed to maternal vascular malperfusion lesions downregulate these processes. Intermediate monocytes might be a source of mitogens implicated in different outcomes related to prematurity.
Article
Cell Biology
Mohammad Lotfollahi, Sergei Rybakov, Karin Hrovatin, Soroor Hediyeh-zadeh, Carlos Talavera-Lopez, Alexander V. Misharin, Fabian J. Theis
Summary: Lotfollahi et al. propose ExpiMap, a biologically informed deep-learning model for interpretable reference mapping of RNA sequencing data. ExpiMap maps cells into biologically understandable components representing known 'gene programs', allowing for detailed analysis and interpretation of single-cell data.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nozomu Takata, Jason M. Miska, Marc A. Morgan, Priyam Patel, Leah K. Billingham, Neha Joshi, Matthew J. Schipma, Zachary J. Dumar, Nikita R. Joshi, Alexander V. Misharin, Ryan B. Embry, Luciano Fiore, Peng Gao, Lauren P. Diebold, Gregory S. McElroy, Ali Shilatifard, Navdeep S. Chandel, Guillermo Oliver
Summary: Using eye organoids and mouse models, the authors demonstrate that lactate plays a bioenergetic independent role as a cell signaling molecule during early eye formation in mice. The study reveals the importance of aerobic glycolysis in retinal development and identifies specific glucose transporters and glycolytic genes involved. Lactate-mediated upregulation of eye-field transcription factors is controlled by epigenetic modifications.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G. R. Scott Budinger
Summary: Using a mouse lung transplant model, researchers found that excessive activation of Toll-like receptors 2 and 4 (TLR2 and -4) on nonclassical monocytes leads to the release of CXCL2, which worsens primary graft dysfunction (PGD). Deleting CD11b in nonclassical monocytes increases CXCL2 production, while administering a CD11b agonist can inhibit CXCL2 production and alleviate PGD. Additionally, the molecule HMGB1 induces CXCL2 production via TLR4/MyD88 in nonclassical monocytes, and inhibiting HMGB1 can attenuate PGD. This study suggests that CD11b may be a potential therapeutic target for preventing PGD in lung transplant recipients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
G. R. Scott Budinger, Alexander V. Misharin, Karen M. Ridge, Benjamin D. Singer, Richard G. Wunderink
Summary: The COVID-19 pandemic is a major public health crisis of our generation, with severe patients expected to continue filling hospitals and intensive care units. While there are similarities in the clinical presentation and pathobiology of ARDS between pneumonia caused by SARS-CoV-2 and other respiratory pathogens, there are also unique features that could be targeted for therapeutics.
JOURNAL OF CLINICAL INVESTIGATION
(2021)