The skeleton in the closet: actin cytoskeletal remodeling in β-cell function

HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells

(2015) Zhiyong Wang et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Short Term Exposure of Beta Cells to Low Concentrations of Interleukin-1β Improves Insulin Secretion through Focal Adhesion and Actin Remodeling and Regulation of Gene Expression

(2015) Caroline Arous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin α1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance

(2015) Ashley S. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin depolymerisation and crosslinking join forces with myosin II to contract actin coats on fused secretory vesicles

(2015) P. Miklavc et al.   JOURNAL OF CELL SCIENCE

Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies

(2015) Peter Hoboth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAG3 regulates formation of the SNARE complex and insulin secretion

(2015) V Iorio et al.   Cell Death & Disease

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

(2014) Ragadeepthi Tunduguru et al.   BIOCHEMICAL PHARMACOLOGY

Cadherin Engagement Improves Insulin Secretion of Single Human β-Cells

(2014) Geraldine Parnaud et al.   DIABETES

Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers

(2014) Xiangchen Kong et al.   ENDOCRINOLOGY

YES, a Src Family Kinase, Is a Proximal Glucose-specific Activator of Cell Division Cycle Control Protein 42 (Cdc42) in Pancreatic Islet β Cells

(2014) Stephanie M. Yoder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing

(2014) Perrine Pinon et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

(2014) G. M. Goni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fractalkine (CX3CL1), a new factor protecting β-cells against TNFα

(2014) Sabine Rutti et al.   Molecular Metabolism

 1 integrin is a crucial regulator of pancreatic  -cell expansion

(2013) G. R. Diaferia et al.   DEVELOPMENT

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

(2013) L. Kang et al.   DIABETES

The permissive effects of glucose on receptor-operated potentiation of insulin secretion from mouse islets: a role for ERK1/2 activation and cytoskeletal remodelling

(2013) J. E. Bowe et al.   DIABETOLOGIA

Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin

(2013) S. Asahara et al.   DIABETOLOGIA

Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion

(2013) C. Arous et al.   DIABETOLOGIA

Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion

(2013) Eita Uenishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CB1Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release

(2013) Katarzyna Malenczyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E-cadherin-integrin crosstalk in cancer invasion and metastasis

(2013) M. Canel et al.   JOURNAL OF CELL SCIENCE

Glucagon-Like Peptide-1 Protects Human Islets against Cytokine-Mediated β-Cell Dysfunction and Death: A Proteomic Study of the Pathways Involved

(2013) Dieter Rondas et al.   JOURNAL OF PROTEOME RESEARCH

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

(2012) Michael A. Kalwat et al.   BIOCHEMICAL PHARMACOLOGY

Myosin motor proteins are involved in the final stages of the secretory pathways: Figure 1

(2012) Lisa M. Bond et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic  -Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

(2012) E. P. Cai et al.   DIABETES

Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton

(2012) I. de Curtis et al.   JOURNAL OF CELL SCIENCE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion

(2012) R. Wollman et al.   NATURE CELL BIOLOGY

High Glucose Predisposes Gene Expression and ERK Phosphorylation to Apoptosis and Impaired Glucose-Stimulated Insulin Secretion via the Cytoskeleton

(2012) Ronne Wee Yeh Yeo et al.   PLoS One

Actin coats and rings promote regulated exocytosis

(2012) Thomas D. Nightingale et al.   TRENDS IN CELL BIOLOGY

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

(2011) Stefan T Arold   CURRENT OPINION IN STRUCTURAL BIOLOGY

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

(2011) D. Rondas et al.   DIABETES

Cyclin-Dependent Kinase 5 Promotes Pancreatic  -Cell Survival via Fak-Akt Signaling Pathways

(2011) M. Daval et al.   DIABETES

Disruption and stabilization of β-cell actin microfilaments differently influence insulin secretion triggered by intracellular Ca2+mobilization or store-operated Ca2+entry

(2011) Jean-Claude Henquin et al.   FEBS LETTERS

Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanismsin Vivo

(2011) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration

(2011) Christa L. Cortesio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion

(2011) Dieter Rondas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The F-actin cortical network is a major factor influencing the organization of the secretory machinery in chromaffin cells

(2011) C. J. Torregrosa-Hetland et al.   JOURNAL OF CELL SCIENCE

Conditional β1-integrin-deficient mice display impaired pancreatic β cell function

(2011) M. Riopel et al.   JOURNAL OF PATHOLOGY

Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis

(2011) Kouichi Mizuno et al.   MOLECULAR BIOLOGY OF THE CELL

Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis

(2011) Michael A. Kalwat et al.   MOLECULAR ENDOCRINOLOGY

Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy

(2011) A. Masedunskas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Myosin Va Recruitment to Dense Core Secretory Granules

(2011) Flora Brozzi et al.   TRAFFIC

A TRP channel contributes to insulin secretion by pancreatic β-cells

(2011) Emily R. Liman   Islets

Glucose-induced ERM protein activation and translocation regulates insulin secretion

(2010) James P. Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Duration of fusion pore opening and the amount of hormone released are regulated by myosin II during kiss-and-run exocytosis

(2010) Ryo Aoki et al.   BIOCHEMICAL JOURNAL

SNARE-mediated membrane traffic is required for focal adhesion kinase signaling and Src-regulated focal adhesion turnover

(2010) Michael Skalski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis

(2010) Stephanie L. Gupton et al.   DEVELOPMENTAL CELL

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell KATPChannels

(2010) Youhou Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kindlins at a glance

(2010) E. Karakose et al.   JOURNAL OF CELL SCIENCE

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

(2009) Sandra Andersson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrins in cell migration - the actin connection

(2009) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival

(2009) Saira Saleem et al.   JOURNAL OF PATHOLOGY

PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase☆

(2009) Amit Gupta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Myosin 2 Maintains an Open Exocytic Fusion Pore in Secretory Epithelial Cells

(2009) Purnima Bhat et al.   MOLECULAR BIOLOGY OF THE CELL

Signaling Pathways Implicated in the Stimulation of β-Cell Proliferation by Extracellular Matrix

(2009) Géraldine Parnaud et al.   MOLECULAR ENDOCRINOLOGY

Calcium flickers steer cell migration

(2009) Chaoliang Wei et al.   NATURE

Regulation of Insulin Secretion by Phosphatidylinositol-4,5-Bisphosphate

(2009) Alejandra Tomas et al.   TRAFFIC

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic  -Cells

(2008) K. Bouzakri et al.   DIABETES

Dual Effect of Cell-Cell Contact Disruption on Cytosolic Calcium and Insulin Secretion

(2008) Fabienne Jaques et al.   ENDOCRINOLOGY

Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic β-Cell Function

(2008) Eva Hammar et al.   ENDOCRINOLOGY

Cell responses regulated by early reorganization of actin cytoskeleton

(2008) E.A. Papakonstanti et al.   FEBS LETTERS

Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4

(2008) Jenna L. Jewell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin II Contributes to Fusion Pore Expansion during Exocytosis

(2008) Patricia Ñeco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin

(2008) Charles A. Easley et al.   CELL MOTILITY AND THE CYTOSKELETON

Nonmuscle myosin II moves in new directions

(2007) M. A. Conti et al.   JOURNAL OF CELL SCIENCE