Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing

Complete integrin headpiece opening in eight steps

(2013) Jieqing Zhu et al.   JOURNAL OF CELL BIOLOGY

pH sensing by FAK-His58 regulates focal adhesion remodeling

(2013) Chang-Hoon Choi et al.   JOURNAL OF CELL BIOLOGY

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

Mechanical control of integrin-mediated adhesion and signaling

(2012) David Boettiger   CURRENT OPINION IN CELL BIOLOGY

Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif

(2012) Luke A. Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Cross-Correlated Fluctuation Analysis Reveals Phosphorylation-Regulated Paxillin-FAK Complexes in Nascent Adhesions

(2011) Colin K. Choi et al.   BIOPHYSICAL JOURNAL

The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish

(2011) E. Pluskota et al.   BLOOD

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

The C terminus of talin links integrins to cell cycle progression

(2011) Pengbo Wang et al.   JOURNAL OF CELL BIOLOGY

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Anoikis: an emerging hallmark in health and diseases

(2011) ML Taddei et al.   JOURNAL OF PATHOLOGY

Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis

(2011) Soraya Sin et al.   JNCI-Journal of the National Cancer Institute

Endothelial cell talin1 is essential for embryonic angiogenesis

(2010) Susan J. Monkley et al.   DEVELOPMENTAL BIOLOGY

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis

(2010) Nicholas O. Deakin et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Diversity in Integrin/Talin Interactions

(2010) Nicholas J. Anthis et al.   STRUCTURE

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

β1Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1

(2009) J. Angelo Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity

(2009) Thomas A. Bunch   JOURNAL OF BIOLOGICAL CHEMISTRY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia - differential roles for paxillin and p130Cas

(2009) N. K. Zouq et al.   JOURNAL OF CELL SCIENCE

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Interaction between the Cytoplasmic Domain of the Hyaluronate Receptor Layilin and the Talin F3 Subdomain

(2008) Kate L. Wegener et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology

Lamellipodia nucleation by filopodia depends on integrin occupancy and downstream Rac1 signaling

(2007) Hervé Guillou et al.   EXPERIMENTAL CELL RESEARCH