Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

(2011) Steven N. Hochwald et al.   CELL CYCLE

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

(2011) D. Rondas et al.   DIABETES

The F-actin cortical network is a major factor influencing the organization of the secretory machinery in chromaffin cells

(2011) C. J. Torregrosa-Hetland et al.   JOURNAL OF CELL SCIENCE

Conditional β1-integrin-deficient mice display impaired pancreatic β cell function

(2011) M. Riopel et al.   JOURNAL OF PATHOLOGY

Association of SNAREs and Calcium Channels with the Borders of Cytoskeletal Cages Organizes the Secretory Machinery in Chromaffin Cells

(2010) Cristina J. Torregrosa-Hetland et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Integrin α3, But Not β1, Regulates Islet Cell Survival and Function via PI3K/Akt Signaling Pathways

(2010) Mansa Krishnamurthy et al.   ENDOCRINOLOGY

Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation

(2010) Bertha C. Elias et al.   Cell Adhesion & Migration

Rac1 inactivation by lethal toxin fromClostridium sordelliimodifies focal adhesions upstream of actin depolymerization

(2009) Blandine Geny et al.   CELLULAR MICROBIOLOGY

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

Integrins in cell migration - the actin connection

(2009) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival

(2009) Saira Saleem et al.   JOURNAL OF PATHOLOGY

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

(2009) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic β-cells

(2008) Rajakrishnan Veluthakal et al.   BIOCHEMICAL PHARMACOLOGY

Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells

(2008) Bharti Bisht et al.   BMC CELL BIOLOGY

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic  -Cells

(2008) K. Bouzakri et al.   DIABETES

Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4

(2008) Jenna L. Jewell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLUT4 Vesicle Recruitment and Fusion Are Differentially Regulated by Rac, AS160, and Rab8A in Muscle Cells

(2008) Varinder K. Randhawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

(2008) Vita M. Golubovskaya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS