YES, a Src Family Kinase, Is a Proximal Glucose-specific Activator of Cell Division Cycle Control Protein 42 (Cdc42) in Pancreatic Islet β Cells

Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion

(2013) Eita Uenishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of NOX-1 expression in beta cells: A positive feedback loop involving the Src-kinase signaling pathway

(2013) J.R. Weaver et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic β-cells

(2013) Yi-Chun Chen et al.   Islets

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells

(2012) Michael A. Kalwat et al.   BIOCHEMICAL PHARMACOLOGY

SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome

(2012) Bernard A Liu et al.   Cell Communication and Signaling

Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic β-Cells

(2012) Jia Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

(2012) Zhanxiang Wang et al.   FEBS Open Bio

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

(2011) Erica M. Kepner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets

(2011) Bhavaani Jayaram et al.   BIOCHEMICAL PHARMACOLOGY

12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation

(2011) N. K. Singh et al.   BLOOD

Hyperglycemia Enhances IGF-I-Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKC -Dependent Manner in Vascular Smooth Muscle Cells

(2011) G. Xi et al.   DIABETES

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

(2011) D. Rondas et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanismsin Vivo

(2011) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion

(2011) Dieter Rondas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulus-inducedS-Nitrosylation of Syntaxin 4 Impacts Insulin Granule Exocytosis

(2011) Dean A. Wiseman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation

(2011) M. Kuroiwa et al.   JOURNAL OF CELL SCIENCE

Control of the Intracellular Redox State by Glucose Participates in the Insulin Secretion Mechanism

(2011) Eduardo Rebelato et al.   PLoS One

Metabolic amplifying pathway increases both phases of insulin secretion independently of β-cell actin microfilaments

(2010) Nizar I. Mourad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylation of the Cool-1/β-Pix Protein Serves as a Regulatory Signal for the Migration and Invasive Activity of Src-transformed Cells

(2010) Qiyu Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

The Rho Guanosine 5′-Triphosphatase, Cell Division Cycle 42, Is Required for Insulin-Induced Actin Remodeling and Glucagon-Like Peptide-1 Secretion in the Intestinal Endocrine L Cell

(2009) Gareth E. Lim et al.   ENDOCRINOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES