Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

(2018) Sandybell Anorga et al.   FASEB JOURNAL

The Dual Role of Bone Morphogenetic Proteins in Cancer

(2018) Duc-Hiep Bach et al.   Molecular Therapy-Oncolytics

Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance

(2017) Catherine Zabkiewicz et al.   ENDOCRINE-RELATED CANCER

Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation

(2017) Yali Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-β/Smad pathway in vitro and in vivo

(2017) Wenzhen Yu et al.   Oncology Letters

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

(2017) Zhengkui Zhang et al.   Nature Communications

MicroRNA-137 inhibits BMP7 to enhance the epithelial-mesenchymal transition of breast cancer cells

(2017) Xuexiang Ying et al.   Oncotarget

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b

(2017) David Witte et al.   Scientific Reports

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non–Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion

(2016) Sebastian Marwitz et al.   CANCER RESEARCH

Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

(2016) Rohan Samarakoon et al.   FASEB JOURNAL

Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma

(2016) Jie Fan et al.   HUMAN PATHOLOGY

A dual prognostic role for the TGFβ receptors in human breast cancer

(2016) Ibrahim Y. Hachim et al.   HUMAN PATHOLOGY

Bone Morphogenetic Protein-7 Inhibits EMT-Associated Genes in Breast Cancer

(2015) Xuexiang Ying et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses

(2015) Jessica M. Overstreet et al.   FASEB JOURNAL

Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses

(2015) Rohan Samarakoon et al.   JOURNAL OF PATHOLOGY

Loss of Klotho in CKD Breaks One's Heart

(2015) H. Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma

(2015) Xiaowei Tang et al.   LABORATORY INVESTIGATION

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

(2015) Hendrik Ungefroren et al.   Oncotarget

Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway

(2015) Jiang Geng et al.   Oncotarget

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

(2014) Jessica M. Overstreet et al.   CELLULAR SIGNALLING

TGFβ: A player on multiple fronts in the tumor microenvironment

(2014) Fabian Caja et al.   Journal of Immunotoxicology

Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling

(2014) Xu Guan et al.   JOURNAL OF PATHOLOGY

The Kidney Is the Principal Organ Mediating Klotho Effects

(2014) K. Lindberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

(2014) D. R. Principe et al.   JNCI-Journal of the National Cancer Institute

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

A functional role for Smad7 in sustaining colon cancer cell growth and survival

(2014) C Stolfi et al.   Cell Death & Disease

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

(2013) Rohan Samarakoon et al.   CELLULAR SIGNALLING

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis

(2013) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis

(2013) G A Bjerke et al.   ONCOGENE

PPM1A is a RelA phosphatase with tumor suppressor-like activity

(2013) X Lu et al.   ONCOGENE

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo

(2013) M Yu et al.   ONCOGENE

A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells

(2012) C M Tate et al.   CELL DEATH AND DIFFERENTIATION

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

(2012) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Klotho

(2012) Sharon M. Moe   CIRCULATION

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression

(2012) M. L. Stallings-Mann et al.   Science Translational Medicine

Epigenetic silencing of the tumor suppressor klotho in human breast cancer

(2011) Tami Rubinek et al.   BREAST CANCER RESEARCH AND TREATMENT

Suppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs

(2011) Afzal M. Dogar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

(2011) Rohan Samarakoon et al.   PLoS One

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer

(2011) Jie Pan et al.   TUMOR BIOLOGY

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

A Colorectal Cancer Expression Profile That Includes Transforming Growth Factor β Inhibitor BAMBI Predicts Metastatic Potential

(2009) Johannes Fritzmann et al.   GASTROENTEROLOGY

BAMBIgene is epigenetically silenced in subset of high-grade bladder cancer

(2009) Sann Sanda Khin et al.   INTERNATIONAL JOURNAL OF CANCER

TGF-β mediates PTEN suppression and cell motility through calcium-dependent PKC-α activation in pancreatic cancer cells

(2008) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Smad7 induces hepatic metastasis in colorectal cancer

(2008) S K Halder et al.   BRITISH JOURNAL OF CANCER

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus

(2008) Vincenzo Villanacci et al.   HUMAN PATHOLOGY

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling

(2008) Rohan Samarakoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells

(2008) Rohan Samarakoon et al.   THROMBOSIS AND HAEMOSTASIS

Prognostic significance of BMP and activin membranebound inhibitor in colorectal cancer

(2008) Nozomi Togo et al.   WORLD JOURNAL OF GASTROENTEROLOGY