Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
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Title
Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 10, Pages 8655-8665
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2011-01-06
DOI
10.1074/jbc.m110.174037
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Note: Only part of the references are listed.- Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
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- Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
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- Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
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- Biomarkers for epithelial-mesenchymal transitions
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- (2009) S.-K. Cha et al. MOLECULAR PHARMACOLOGY
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
- (2009) I Wolf et al. ONCOGENE
- Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation
- (2009) R. Goetz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons
- (2008) S. John Weroha et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β
- (2008) Toru Kawai et al. LABORATORY INVESTIGATION
- Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
- (2008) I Wolf et al. ONCOGENE
- Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
- (2008) S.-K. Cha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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