TGFβ: A player on multiple fronts in the tumor microenvironment

Two Faces of TGF-Beta1 in Breast Cancer

(2014) Joanna Magdalena Zarzynska   MEDIATORS OF INFLAMMATION

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

(2013) Jiao Peng et al.   CANCER LETTERS

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

Possible association between TGF-β1 polymorphism and oral cancer

(2013) N. K. Carneiro et al.   International Journal of Immunogenetics

Transforming Growth Factor β-regulated MicroRNA-29a Promotes Angiogenesis through Targeting the Phosphatase and Tensin Homolog in Endothelium

(2013) Jun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment

(2013) Brent A. Hanks et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

(2013) Neil E. Bhola et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-  Promotes Immune Responses in the Presence of Mesenchymal Stem Cells

(2013) C. Xu et al.   JOURNAL OF IMMUNOLOGY

CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma

(2013) A Shukla et al.   ONCOGENE

TGF-β1 regulates cell fate during epithelial–mesenchymal transition by upregulating survivin

(2013) J Lee et al.   Cell Death & Disease

Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling

(2013) B. R. Achyut et al.   PLoS Genetics

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

Reactive oxygen species stimulates epithelial mesenchymal transition in normal human epidermal keratinocytes via TGF-beta secretion

(2012) Teruhisa Fukawa et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

(2012) Jeffrey P Marcoe et al.   NATURE IMMUNOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

(2012) L J A C Hawinkels et al.   ONCOGENE

Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer

(2011) Karl-Hermann Schlingensiepen et al.   CANCER SCIENCE

Anti-Transforming Growth Factor   Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

(2010) Z. Zhong et al.   CLINICAL CANCER RESEARCH

Osteoclast synthesis and secretion and activation of latent transforming growth factor β

(2010) Merry Jo Oursler   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

(2010) U. Bogdahn et al.   NEURO-ONCOLOGY

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

ConceptGen: a gene set enrichment and gene set relation mapping tool

(2009) Maureen A. Sartor et al.   BIOINFORMATICS

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer

(2009) Brian Bierie et al.   JOURNAL OF CLINICAL INVESTIGATION

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic Blockade of Transforming Growth Factor-  Signaling Augments the Efficacy of Immunogene Therapy

(2008) S. Kim et al.   CANCER RESEARCH

Transforming Growth Factor   Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

(2008) J.-S. Nam et al.   CANCER RESEARCH

Regulation of TGF-β family signaling by E3 ubiquitin ligases

(2008) Yasumichi Inoue et al.   CANCER SCIENCE

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE