Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling

Potential approaches to reverse or repair renal fibrosis

(2014) Desiree Tampe et al.   Nature Reviews Nephrology

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection

(2013) Ming-Chang Hu et al.   KIDNEY INTERNATIONAL

Epithelial-mesenchymal crosstalk alteration in kidney fibrosis

(2012) Marco Prunotto et al.   JOURNAL OF PATHOLOGY

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Role of Klotho in Aging, Phosphate Metabolism, and CKD

(2011) George B. John et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

(2011) Xiao-Ming Meng et al.   JOURNAL OF PATHOLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

The Origin of Renal Fibroblasts and Progression of Kidney Disease

(2009) H. Terence Cook   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice

(2009) Jie Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

(2009) Yuhong Wang et al.   HYPERTENSION

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FGF23–parathyroid interaction: implications in chronic kidney disease

(2009) Hirotaka Komaba et al.   KIDNEY INTERNATIONAL

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Klotho gene family as a regulator of endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY