Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/ -Catenin/Axin2 Pathway

(2016) Y. Li et al.   CANCER RESEARCH

Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex

(2016) Yuxuan Miao et al.   IMMUNITY

USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome

(2016) Meng Lin et al.   MOLECULAR CELL

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations

(2015) Yosua Adi Kristariyanto et al.   BIOCHEMICAL JOURNAL

Pan-cancer analysis of TCGA data reveals notable signaling pathways

(2015) Richard Neapolitan et al.   BMC CANCER

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Deubiquitinases (DUBs) and DUB inhibitors: a patent review

(2015) Pershang Farshi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation

(2015) Mingjin Yang et al.   NATURE IMMUNOLOGY

Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

(2015) Vivien Landré et al.   Oncotarget

A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours

(2014) A P Carneiro et al.   BRITISH JOURNAL OF CANCER

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

(2014) Wei-Chien Yuan et al.   MOLECULAR CELL

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

An In Vivo Functional Screen Identifies ST6GalNAc2 Sialyltransferase as a Breast Cancer Metastasis Suppressor

(2014) N. Murugaesu et al.   Cancer Discovery

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6

(2013) Xiaofei Zhang et al.   EMBO JOURNAL

TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis

(2013) Long Zhang et al.   MOLECULAR CELL

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity

(2012) Frances L. Shaw et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation

(2012) Long Zhang et al.   MOLECULAR CELL

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Linear polyubiquitin chains

(2011) Kazuhiro Iwai   CELL CYCLE

Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation

(2011) Long Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

K11-linked ubiquitin chains as novel regulators of cell division

(2011) Katherine E. Wickliffe et al.   TRENDS IN CELL BIOLOGY

Gene Expression-Based Classification of Non-Small Cell Lung Carcinomas and Survival Prediction

(2010) Jun Hou et al.   PLoS One

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

The regulation of TGF  signal transduction

(2009) A. Moustakas et al.   DEVELOPMENT

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL