The Dual Role of Smad7 in the Control of Cancer Growth and Metastasis

MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7

(2013) Qiang Li et al.   CANCER LETTERS

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

Inhibitory role of Smad7 in hepatocarcinogenesis in mice andin vitro

(2013) Jia Wang et al.   JOURNAL OF PATHOLOGY

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration

(2012) Maria Ekman et al.   MOLECULAR BIOLOGY OF THE CELL

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

(2012) A L Smith et al.   ONCOGENE

Inhibitory Smad7: Emerging Roles in Health and Disease

(2012) Marco A. Briones-Orta et al.   Current Molecular Pharmacology

Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior

(2011) IRINI THEOHARI et al.   APMIS

Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling

(2011) Xiaohua Yan et al.   BIOCHEMICAL JOURNAL

Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells

(2011) Sangmin Kim et al.   CANCER LETTERS

Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon Cancer

(2011) P. Papageorgis et al.   CANCER RESEARCH

Smad7 Expression in T cells Prevents Colitis-Associated Cancer

(2011) A. Rizzo et al.   CANCER RESEARCH

Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-β1-induced negative regulation of IL-1R/TLR signaling

(2010) Youn Sook Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7

(2010) M. L. Slattery et al.   CANCER RESEARCH

Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo

(2010) Kyle A. DiVito et al.   Pigment Cell & Melanoma Research

Low-Level Expression of Smad7 Correlates with Lymph Node Metastasis and Poor Prognosis in Patients with Pancreatic Cancer

(2009) Peng Wang et al.   ANNALS OF SURGICAL ONCOLOGY

Association of common genetic variants in SMAD7 and risk of colon cancer

(2009) C. L. Thompson et al.   CARCINOGENESIS

Smad4/Smad7 balance: A role of tumorigenesis in gastric cancer

(2009) Aimin Leng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Antimetastatic Role of Smad4 Signaling in Colorectal Cancer

(2009) Bixiang Zhang et al.   GASTROENTEROLOGY

Nuclear Function of Smad7 Promotes Myogenesis

(2009) T. Miyake et al.   MOLECULAR AND CELLULAR BIOLOGY

Smad7 induces hepatic metastasis in colorectal cancer

(2008) S K Halder et al.   BRITISH JOURNAL OF CANCER

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

Smad7 Is Required for the Development and Function of the Heart

(2008) Qian Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21

(2008) Albert Tenesa et al.   NATURE GENETICS