Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses

Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity

(2014) Jessica M. Overstreet et al.   CELLULAR SIGNALLING

Targeted Deletion of p53 in the Proximal Tubule Prevents Ischemic Renal Injury

(2014) Y. Ying et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miR-21–Containing Microvesicles from Injured Tubular Epithelial Cells Promote Tubular Phenotype Transition by Targeting PTEN Protein

(2013) Yang Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy

(2013) M. Refik Gökmen et al.   ANNALS OF INTERNAL MEDICINE

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

(2013) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity

(2012) Kahori Miyoshi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β signaling in tissue fibrosis: Redox controls, target genes and therapeutic opportunities

(2012) Rohan Samarakoon et al.   CELLULAR SIGNALLING

PTEN at a glance

(2012) Y. Shi et al.   JOURNAL OF CELL SCIENCE

Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney

(2012) Lucas L. Falke et al.   MATRIX BIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

(2011) Rohan Samarakoon et al.   CELL AND TISSUE RESEARCH

Loss of PTEN Expression by Dermal Fibroblasts Causes Skin Fibrosis

(2011) Sunil K. Parapuram et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Angiotensin II as a Morphogenic Cytokine Stimulating Renal Fibrogenesis

(2011) C. Ruster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

(2011) William G. Couser et al.   KIDNEY INTERNATIONAL

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

(2011) Zhihu Ding et al.   NATURE

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Activation of p53 Promotes Renal Injury in Acute Aristolochic Acid Nephropathy

(2009) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

(2009) Robert L. Chevalier et al.   KIDNEY INTERNATIONAL

TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

(2009) Mitsuo Kato et al.   NATURE CELL BIOLOGY

Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis

(2008) Xu Shi-Wen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Transforming Growth Factor-β Requires Its Target Plasminogen Activator Inhibitor-1 for Cytostatic Activity

(2008) Roderik M. Kortlever et al.   JOURNAL OF BIOLOGICAL CHEMISTRY