Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions

Kynurenic acid downregulates IL-17/1L-23 axis in vitro

(2017) Sanam Salimi Elizei et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Correlations of Kynurenic Acid, 3-Hydroxykynurenine, sIL-2R, IFN-α, and IL-4 with Clinical Symptoms During Acute Relapse of Schizophrenia

(2017) Kinga Szymona et al.   NEUROTOXICITY RESEARCH

Serum kynurenic acid is reduced in affective psychosis

(2017) B E Wurfel et al.   Translational Psychiatry

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

(2017) Marcela Cruz-Haces et al.   Translational Neurodegeneration

High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway

(2017) Keon-Joo Lee et al.   Experimental Neurobiology

The effect of kynurenic acid on the synthesis of selected cytokines by murine splenocytes – in vitro and ex vivo studies

(2016) Joanna Małaczewska et al.   Central European Journal of Immunology

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects

(2016) Zsófia Majláth et al.   Current Neuropharmacology

Effect of feed supplementation with kynurenic acid on the morphology of the liver, kidney and gills in rainbow trout (Oncorhynchus mykiss Walbaum, 1792), healthy and experimentally infected with Yersinia ruckeri

(2016) E Kaczorek et al.   JOURNAL OF FISH DISEASES

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

(2016) Martina Curto et al.   JOURNAL OF HEADACHE AND PAIN

Altered kynurenine pathway metabolites in serum of chronic migraine patients

(2016) Martina Curto et al.   JOURNAL OF HEADACHE AND PAIN

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

(2016) Jennifer M. Parrott et al.   Journal of Neuroinflammation

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

(2016) Verena Katharina Raker et al.   Frontiers in Immunology

Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity

(2015) J.J. Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function

(2015) Thomas H. Thatcher et al.   IMMUNOLOGY

Utility of Kynurenic Acid for Non-Invasive Detection of Metastatic Spread to Lymph Nodes in Non-Small Cell Lung Cancer

(2015) Dariusz Sagan et al.   International Journal of Medical Sciences

Involvement of Intracellular Calcium Mobilization in IL-8 Activation in Human Retinal Pigment Epithelial Cells

(2015) I.-H. Yang et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes

(2015) Adriana Pérez-González et al.   JOURNAL OF MOLECULAR MODELING

Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

(2015) Lucia García-Lara et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes

(2015) Gregory F. Oxenkrug   MOLECULAR NEUROBIOLOGY

Aryl hydrocarbon receptor is necessary to protect fetal human pulmonary microvascular endothelial cells against hyperoxic injury: Mechanistic roles of antioxidant enzymes and RelB

(2015) Shaojie Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alternative kynurenic acid synthesis routes studied in the rat cerebellum

(2015) Tonali Blanco Ayala   Frontiers in Cellular Neuroscience

Kynurenic Acid Content in Selected Culinary Herbs and Spices

(2015) Michal P. Turski et al.   Journal of Chemistry

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

(2015) Michael Platten et al.   Frontiers in Immunology

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease

(2015) Simon P. Jones et al.   PLoS One

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

The role of serotonin and its receptors in activation of immune responses and inflammation

(2014) M. S. Shajib et al.   Acta Physiologica

Kynurenic acid inhibits colon cancer proliferation in vitro: effects on signaling pathways

(2014) Katarzyna Walczak et al.   AMINO ACIDS

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17

(2014) José L. Maravillas-Montero et al.   JOURNAL OF IMMUNOLOGY

The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

(2014) Levke Steiner et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

(2014) Octavio Silva-García et al.   MEDIATORS OF INFLAMMATION

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

Effect of kynurenic acid on the viability of probiotics in vitro

(2014) Jadwiga Dolecka et al.   Pharmacological Reports

Kynurenic acid enhances expression of p21 Waf1/Cip1 in colon cancer HT-29 cells

(2014) Katarzyna Walczak et al.   Pharmacological Reports

Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells

(2014) Katarzyna Walczak et al.   Pharmacological Reports

Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology

(2014) Seray Adams et al.   PLoS One

The two faces of IL-6 in the tumor microenvironment

(2014) Daniel T. Fisher et al.   SEMINARS IN IMMUNOLOGY

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Early Activation of the Kynurenine Pathway Predicts Early Death and Long‐term Outcome in Patients Resuscitated From Out‐of‐Hospital Cardiac Arrest

(2014) Giuseppe Ristagno et al.   Journal of the American Heart Association

Stress-Induced Increase in Kynurenic Acid as a Potential Biomarker for Patients With Schizophrenia and Distress Intolerance

(2014) Joshua Chiappelli et al.   JAMA Psychiatry

Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking

(2014) Rachael Zoe Murray et al.   Frontiers in Immunology

Aryl Hydrocarbon Receptor and Kynurenine: Recent Advances in Autoimmune Disease Research

(2014) Nam Trung Nguyen et al.   Frontiers in Immunology

Kinase AKT controls innate immune cell development and function

(2013) Yan Zhang et al.   IMMUNOLOGY

Changes in Plasma Kynurenic Acid Concentration in Septic Shock Patients Undergoing Continuous Veno-Venous Haemofiltration

(2013) Wojciech Dabrowski et al.   INFLAMMATION

Activation of indoleamine 2,3-dioxygenase by LPS in a porcine model

(2013) Elisa Wirthgen et al.   Innate Immunity

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis

(2013) Donna M Wilcock et al.   Journal of Neuroinflammation

Kynurenic Acid in Synovial Fluid and Serum of Patients with Rheumatoid Arthritis, Spondyloarthropathy, and Osteoarthritis

(2013) J. Parada-Turska et al.   JOURNAL OF RHEUMATOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

GPR35 Activation Reduces Ca2+ Transients and Contributes to the Kynurenic Acid-Dependent Reduction of Synaptic Activity at CA3-CA1 Synapses

(2013) Rolando Berlinguer-Palmini et al.   PLoS One

Kynurenic acid in human renal cell carcinoma: its antiproliferative and antimigrative action on Caki-2 cells

(2012) Katarzyna Walczak et al.   AMINO ACIDS

Aryl hydrocarbon receptor ligand effects in RBL2H3 cells

(2012) Kristina Maaetoft-Udsen et al.   Journal of Immunotoxicology

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Lack of Modulation of Nicotinic Acetylcholine Alpha-7 Receptor Currents by Kynurenic Acid in Adult Hippocampal Interneurons

(2012) Peter Dobelis et al.   PLoS One

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

(2011) Linnéa Asp et al.   Journal of Inflammation-London

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Melatonin and Elimination of Kynurenines in Children with Down's Syndrome

(2011) J. Uberos et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

(2011) Zoltán Tiszlavicz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells

(2011) Katarzyna Walczak et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

Tryptophan metabolism, from nutrition to potential therapeutic applications

(2010) Nathalie Le Floc’h et al.   AMINO ACIDS

Expression of functional GPR35 in human iNKT cells

(2010) Silvia Fallarini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

(2010) Laura Jenkins et al.   BIOCHEMICAL JOURNAL

Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome

(2010) David M. Christmas et al.   NUTRITION RESEARCH

G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium

(2010) Yuhua Yang et al.   PHARMACOLOGY

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

(2010) Cornelia Kiank et al.   PLoS One

Inflammation-associated depression: From serotonin to kynurenine

(2010) Robert Dantzer et al.   PSYCHONEUROENDOCRINOLOGY

Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia

(2010) K. R. Linderholm et al.   SCHIZOPHRENIA BULLETIN

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort

(2009) Gerard Clarke et al.   BMC GASTROENTEROLOGY

Indoleamine 2,3-Dioxygenase, an Emerging Target for Anti-Cancer Therapy

(2009) X. Liu et al.   CURRENT CANCER DRUG TARGETS

Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions

(2009) Marita C. Barth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human SCAMP5, a Novel Secretory Carrier Membrane Protein, Facilitates Calcium-Triggered Cytokine Secretion by Interaction with SNARE Machinery

(2009) C. Han et al.   JOURNAL OF IMMUNOLOGY

Hypersensitivity of Aryl Hydrocarbon Receptor-Deficient Mice to Lipopolysaccharide-Induced Septic Shock

(2009) H. Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms

(2009) J. C. Schefold et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels

(2009) M.H. Selina Mok et al.   NEUROPHARMACOLOGY

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Micromolar concentration of kynurenic acid in rat small intestine

(2008) D. Kuc et al.   AMINO ACIDS

High concentration of kynurenic acid in bile and pancreatic juice

(2008) Piotr Paluszkiewicz et al.   AMINO ACIDS

Presence of kynurenic acid in food and honeybee products

(2008) Michal P. Turski et al.   AMINO ACIDS

Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission

(2008) J. J. Arnaiz-Cot et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-κB Family Member RelB

(2008) Carolyn J. Baglole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat

(2008) Lieve Desbonnet et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III

(2008) Q. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity

(2008) p. fitzgerald et al.   NEUROGASTROENTEROLOGY AND MOTILITY