Editorial Material
Endocrinology & Metabolism
Zhongjie Fu, Lois E. H. Smith
Summary: Pathologic angiogenesis in eye diseases leading to blindness can be attributed to cell senescence, as demonstrated by the bioinformatics study conducted by Crespo-Garcia, Tsuruda, and Dejda. Their findings were validated in human and mouse retina models, where clearance of senescent cells effectively suppressed neovessel growth.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Xinxuan Cheng, Danxue He, Chunyan Liao, Sijie Lin, Liying Tang, Yuan-Liang Wang, Jiaoyue Hu, Wei Li, Zuguo Liu, Yalin Wu, Yi Liao
Summary: The accumulation of all-trans-retinal (atRAL) has been proposed as a pathogenic factor in Stargardt disease type 1 (STGD1) and age-related macular degeneration (AMD). The study showed that atRAL induced complement activation through the alternative pathway in retinal pigment epithelium (RPE) cells, and led to the production of interleukin-1 beta. Inhibition of p38 and c-Jun N-terminal kinase (JNK) signaling pathways ameliorated complement activation in RPE cells, suggesting a potential therapeutic target for macular degeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Jiali Wu, Jing Hu, Fang Zhang, Qihuang Jin, Xiaodong Sun
Summary: Diabetic retinopathy, a complication of diabetes, is influenced by inflammation. This study demonstrates that high glucose levels enhance IL-17A-induced gene expression in retinal pigment epithelium cells through histone acetylation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
M. Helena Cardoso, Michael J. Hall, Thomas Burgoyne, Pedro Fale, Tina Storm, Cristina Escrevente, Pedro Antas, Miguel C. Seabra, Clare E. Futter
Summary: This study aimed to model the effects of chloroquine on the retinal pigment epithelium in vivo and investigate the impact of mild chloroquine treatment on lysosome function and turnover. The research found that low-dose chloroquine treatment inhibits lysosome reformation, leading to a gradual depletion of lysosomes' ability to interact with cargo-carrying vacuoles and degrade their content. The accumulation of pro-cathepsin D and LAMP1 reflects the inhibition of normal turnover of lysosomal constituents and possibly lysosomes themselves. Understanding the mechanisms underlying lysosome reformation may contribute to the development of new treatments for chloroquine-induced retinopathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Lyndsay L. Leach, Nicholas J. Hanovice, Stephanie M. George, Ana E. Gabriel, Jeffrey M. Gross
Summary: Research has revealed that zebrafish RPE has strong intrinsic regenerative potential, with elements of immune response identified as critical mediators in the regeneration process. Macrophage/microglia cells are responsive to RPE damage and essential for the timely progression of regenerative response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Jongmin Kim, Yeo Jin Lee, Jae Yon Won
Summary: This review highlights the roles and pathogenesis of retinal pigment epithelium (RPE) in AMD, emphasizing the importance of understanding the etiology of AMD and discussing potential treatment strategies targeting RPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Romain Touze, Marc M. Abitbol, Dominique Bremond-Gignac, Matthieu P. Robert
Summary: This study confirms the dysfunction of the retinal pigment epithelium (RPE) in patients with neurofibromatosis type 1 (NF1), characterized by a lower dark trough (DT) and a corresponding higher light peak (LP)/DT ratio. This pattern may be due to a dysregulation of melanocytogenesis, leading to disrupted calcium ion flux and abnormal polarization of the RPE.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Song Yang, Jun Zhou, Dengwen Li
Summary: The retinal pigment epithelium is crucial for visual functions, but damage to its structure and function can lead to various retinopathies with no cure currently available. Understanding the development, function, and pathobiology of the retinal pigment epithelium is essential for preventing and treating retinopathies. This review discusses potential strategies for treatment and provides new perspectives for future research in this field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Biola F. Egbowon, Enzo Fornari, Joseph M. Pally, Alan J. Hargreaves, Bob Stevens, T. Martin Mcginnity, Barbara K. Pierscionek
Summary: This study demonstrates that human RPE cell lines (ARPE-19) can be cultured on ultrathin suspended electrospun nanofibre scaffolds (ENS) composed of hydrophobic polymer polyacrylonitrile (PAN) and a water-soluble aliphatic diamine, without or with fluocinolone acetonide (FA) treatment. The cells survived and maintained their morphology for up to 150 days with FA-treated ENS, showing an epithelial phenotype with biomarkers critical for retinal characteristics. This technique has potential for subretinal transplantation.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Jongmin Kim, Jae Yon Won
Summary: As the world ages, the number of age-related diseases, particularly those related to retinal pigment epithelium (RPE) degeneration, has increased. Photobiomodulation (PBM), a non-invasive treatment using red and near-infrared light, has shown potential as a new treatment for ocular diseases. Recent studies have demonstrated its antioxidant effect, making it a promising approach to cure RPE degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jeremie Canonica, Min Zhao, Tatiana Favez, Emmanuelle Gelize, Laurent Jonet, Laura Kowalczuk, Justine Guegan, Damien Le Menuet, Say Viengchareun, Marc Lombes, Eric Pussard, Yvan Arsenijevic, Francine Behar-Cohen
Summary: Glucocorticoids are commonly used drugs to treat retinal diseases, but the transcriptional regulations induced by GR and MR activation in RPE cells are not well understood. The study found that in the human eye, cortisol is the main ligand for GR and MR, and genes regulated by aldosterone and cortisol + RU-486 can mimic an imbalance toward MR activation. This activation in RPE cells may contribute to retinal pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mohamed A. Faynus, Jeffrey K. Bailey, Britney O. Pennington, Mika Katsura, Duncan A. Proctor, Ashley K. Yeh, Sneha Menon, Dylan G. Choi, Jane S. Lebkowski, Lincoln Johnson, Dennis O. Clegg
Summary: Dry age-related macular degeneration (AMD) is a common eye disease with no current treatment options. Using microcarrier technology for cell culture allows efficient large-scale production of therapeutic retinal pigmented epithelial cells, fulfilling the treatment demands.
BIOENGINEERING-BASEL
(2022)
Article
Genetics & Heredity
Xiuxiu Jin, Jingyang Liu, Weiping Wang, Jiangfeng Li, Guangming Liu, Ruiqi Qiu, Mingzhu Yang, Meng Liu, Lin Yang, Xiaofeng Du, Bo Lei
Summary: This study analyzed the molecular changes of retinal pigment epithelium (RPE) cells during aging through quantitative proteomic analysis. The findings suggest that protein ubiquitination related to RNF123 and RNF149 plays a crucial role in protecting RPE cells from oxidative damage.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Masaaki Ishida, Sunao Sugita, Kenichi Makabe, Shota Fujii, Yoko Futatsugi, Hiroyuki Kamao, Suguru Yamasaki, Noriko Sakai, Akiko Maeda, Michiko Mandai, Masayo Takahashi
Summary: Research has shown that the addition of Y-27632 in vitro can suppress apoptosis, promote cell adhesion and proliferation, and increase the survival rate of transplants. In vivo experiments with human iPS-RPE cell transplantation into monkey eyes showed no obvious retinal toxicity caused by Y-27632.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Summary: The study quantitatively evaluated retinal pigment epithelium changes in patients with age-related macular degeneration using prototype multi-contrast optical coherence tomography. The results showed that multi-contrast OCT is useful for objective evaluation of changes in the retinal pigment epithelium.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Yung-Cheng Huang, Wei-Chiao Chang, Ya-Han Shan, Chao-Yi Lin, Chao-Ling Wang, Chia-Yen Dai, Chi-Kung Ho, Ming-Tsang Wu, Hung-Yi Chuang
Article
Biochemistry & Molecular Biology
Wei-Chiao Chen, James Cheng-Chung Wei, Hsing-Fang Lu, Henry Sung-Ching Wong, Peng Yeong Woon, Yu-Wen Hsu, Jin-Ding Huang, Wei-Chiao Chang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Oncology
Wei-Chiao Chen, Wen-Chang Wang, Hsing-Fang Lu, Yukinori Okada, Wei-Pin Chang, Yii-Her Chou, Hui-Hua Chang, Jin-Ding Huang, Der-Yuan Chen, Wei-Chiao Chang
Article
Cardiac & Cardiovascular Systems
Ho-Chang Kuo, Henry Sung-Ching Wong, Wei-Pin Chang, Ben-Kuen Chen, Mei-Shin Wu, Kuender D. Yang, Kai-Sheng Hsieh, Yu-Wen Hsu, Shih-Feng Liu, Xiao Liu, Wei-Chiao Chang
CIRCULATION-CARDIOVASCULAR GENETICS
(2017)
Article
Genetics & Heredity
Yu-Jia Wang, Kai-Yun Chen, Li-Na Kuo, Wen-Chang Wang, Yu-Wen Hsu, Henry Sung-Ching Wong, Chien-Min Lin, Kuo-Hsing Liao, Yan-Feng Zhang, Yung-Hsiao Chiang, Wei-Chiao Chang
BMC MEDICAL GENETICS
(2018)
Article
Multidisciplinary Sciences
Tsung-Chieh Yao, Su-Wei Chang, Wei-Chiao Chang, Ming-Han Tsai, Sui-Ling Liao, Man-Chin Hua, Shen-Hao Lai, Kuo-Wei Yeh, Yu-Lun Tseng, Wan-Chen Lin, Hui-Ju Tsai, Jing-Long Huang
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Kuo-Hao Ho, Peng-Hsu Chen, Edward Hsi, Chwen-Ming Shih, Wei-Chiao Chang, Chia-Hsiung Cheng, Cheng-Wei Lin, Ku-Chung Chen
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Jhen-Hong Wong, Kuo-Hao Ho, Sean Nam, Wen-Li Hsu, Chia-Hsien Lin, Che-Mai Chang, Jaw-Yuan Wang, Wei-Chiao Chang
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Che-Mai Chang, Henry Sung-Ching Wong, Chien-Yu Huang, Wen-Li Hsu, Zhi-Feng Maio, Siou-Jin Chiu, Yao-Ting Tsai, Ben-Kuen Chen, Yu-Jui Yvonne Wan, Jaw-Yuan Wang, Wei-Chiao Chang
Article
Biotechnology & Applied Microbiology
Che-Mai Chang, Yu-Wen Hsu, Henry Sung-Ching Wong, James Cheng-Chung Wei, Xiao Liu, Hsien-Tzung Liao, Wei-Chiao Chang
Letter
Oncology
Che-Mai Chang, Yu-Ming Liao, Gong-Yau Lan, Wei-Chiao Chang, Yun Yen
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Health Care Sciences & Services
Min-Rou Lin, Che-Mai Chang, Jafit Ting, Jan-Gowth Chang, Wan-Hsuan Chou, Kuei-Jung Huang, Gloria Cheng, Hsiao-Huang Chang, Wei-Chiao Chang
Summary: Marfan syndrome is a rare disease that affects multiple organ systems. This study identified potential pathogenic genes associated with MFS using whole exome sequencing in a Taiwan cohort, and also discovered novel candidate genes. The findings contribute to a better understanding of the pathogenesis of MFS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu, Wei-Chiao Chang
JOURNAL OF BIOMEDICAL SCIENCE
(2017)