The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor

Rapid identification and validation of novel targeted approaches for Glioblastoma: A combined ex vivo-in vivo pharmaco-omic model

(2018) Ahmad Daher et al.   EXPERIMENTAL NEUROLOGY

Sohlh1 suppresses glioblastoma cell proliferation, migration, and invasion by inhibition of Wnt/β-catenin signaling

(2018) Xinyu Liu et al.   MOLECULAR CARCINOGENESIS

Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors

(2017) Martina Ferri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Epigenetically controlled Six3 expression regulates glioblastoma cell proliferation and invasion alongside modulating the activation levels of WNT pathway members

(2017) Baoxin Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

Aberrant Wnt signaling: a special focus in CNS diseases

(2017) Mercedes Arnés et al.   JOURNAL OF NEUROGENETICS

Blocking MIR155HG/miR-155 axis inhibits mesenchymal transition in glioma

(2017) Xuechao Wu et al.   NEURO-ONCOLOGY

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination

(2017) J H Wald et al.   ONCOGENE

Targeting WNT Signaling for Multifaceted Glioblastoma Therapy

(2017) Matthew McCord et al.   Frontiers in Cellular Neuroscience

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors

(2017) Adriana Bajetto et al.   Frontiers in Cellular Neuroscience

Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma

(2017) Takuya Furuta et al.   Oncotarget

Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

(2017) Vladimir N. Ivanov et al.   Oncotarget

RYK promotes the stemness of glioblastoma cells via the WNT/ β-catenin pathway

(2017) Assunta Adamo et al.   Oncotarget

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

(2017) et al.   Genes

PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis

(2017) Veronica Vella et al.   Frontiers in Endocrinology

Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

(2017) Chiara Cilibrasi et al.   PLoS One

MicroRNA-106a-5p facilitates human glioblastoma cell proliferation and invasion by targeting adenomatosis polyposis coli protein

(2016) Dazhi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation

(2016) Kirsten Strømme Kierulf-Vieira et al.   EXPERIMENTAL CELL RESEARCH

Harnessing nanomedicine for therapeutic intervention in glioblastoma

(2016) Anna Gutkin et al.   Expert Opinion on Drug Delivery

Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma

(2016) C. Bastiancich et al.   JOURNAL OF CONTROLLED RELEASE

Clipping the Wings of Glioblastoma: Modulation of WNT as a Novel Therapeutic Strategy

(2016) Abigail K. Suwala et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Expression patterns of Wnt signaling component, secreted frizzled-related protein 3 in astrocytoma and glioblastoma

(2016) NIVES PEĆINA-ŠLAUS et al.   Molecular Medicine Reports

AKT/GSK3β Signaling in Glioblastoma

(2016) Ewelina Majewska et al.   NEUROCHEMICAL RESEARCH

Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway

(2016) Min Li et al.   ONCOLOGY REPORTS

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

(2016) Jessica Roos et al.   PHARMACOLOGY & THERAPEUTICS

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

(2016) Ignacio Sancho-Martinez et al.   Nature Communications

A 4-miRNA signature predicts the therapeutic outcome of glioblastoma

(2016) Michel Mittelbronn et al.   Oncotarget

Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine

(2015) Sang-Soo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-603 promotes glioma cell growth via Wnt/β-catenin pathway by inhibiting WIF1 and CTNNBIP1

(2015) Mian Guo et al.   CANCER LETTERS

Diverse Targets of  -Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse

(2015) Y.-W. Chang et al.   CANCER RESEARCH

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells

(2015) C. Venugopal et al.   CLINICAL CANCER RESEARCH

Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor

(2015) Zhongyong Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Temozolomide-loaded photopolymerizable PEG-DMA-based hydrogel for the treatment of glioblastoma

(2015) Thibaut Fourniols et al.   JOURNAL OF CONTROLLED RELEASE

Evolution of the Karnosky Performance Status throughout life in glioblastoma patients

(2015) Adama Sacko et al.   JOURNAL OF NEURO-ONCOLOGY

Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/β-catenin signaling in glioblastoma

(2015) FengMing Lan et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

(2015) Ulf D. Kahlert et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

WNT signaling in glioblastoma and therapeutic opportunities

(2015) Yeri Lee et al.   LABORATORY INVESTIGATION

miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway

(2015) Weiguang Zhang et al.   MOLECULAR CARCINOGENESIS

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

(2015) I Vassallo et al.   ONCOGENE

Trichosanthin suppresses the proliferation of glioma cells by inhibiting LGR5 expression and the Wnt/β-catenin signaling pathway

(2015) JUNJIE MIAO et al.   ONCOLOGY REPORTS

Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

(2015) Bhuvanalakshmi G et al.   PLoS One

MSX1 inhibits cell migration and invasion through regulating the Wnt/β-catenin pathway in glioblastoma

(2015) Haiquan Tao et al.   TUMOR BIOLOGY

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

(2015) Ran Duan et al.   Oncotarget

Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma

(2015) Weiwei Wang et al.   Oncotarget

LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program

(2015) Xing-gang Mao et al.   Oncotarget

Oncolytic virotherapy for ALL: MSCs to the rescue

(2014) E. M. Horwitz   BLOOD

The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells

(2014) M R Moniri et al.   CANCER GENE THERAPY

Wnt signalling in neuronal differentiation and development

(2014) Nibaldo C. Inestrosa et al.   CELL AND TISSUE RESEARCH

The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish

(2014) T. Young et al.   DEVELOPMENT

The expression of Wnt-inhibitor DKK1 (Dickkopf 1) is determined by intercellular crosstalk and hypoxia in human malignant gliomas

(2014) Ke-Tai Guo et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti–high mobility group box 1 activity: targeting of colon cancer

(2014) Hiroto Kikuchi et al.   JOURNAL OF SURGICAL RESEARCH

Mesenchymal stem cells and cancer: Friends or enemies?

(2014) In-Sun Hong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

New Considerations in Radiation Treatment Planning for Brain Tumors: Neural Progenitor Cell–Containing Niches

(2014) Carmen Kut et al.   SEMINARS IN RADIATION ONCOLOGY

Isolation and in Vitro Characterization of Bovine Amniotic Fluid Derived Stem Cells at Different Trimesters of Pregnancy

(2014) B. Rossi et al.   Stem Cell Reviews and Reports

Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways

(2014) Sachin S. Rathod et al.   FEBS Open Bio

The role of the non-canonical Wnt–planar cell polarity pathway in neural crest migration

(2013) Roberto Mayor et al.   BIOCHEMICAL JOURNAL

Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining

(2013) Hirofumi Hirano et al.   Brain Tumor Pathology

Identification and Characterization of a Small-Molecule Inhibitor of Wnt Signaling in Glioblastoma Cells

(2013) A. De Robertis et al.   MOLECULAR CANCER THERAPEUTICS

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

MiR-328 promotes glioma cell invasion via SFRP1-dependent Wnt-signaling activation

(2013) Sabit Delic et al.   NEURO-ONCOLOGY

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

Physiological Role of β-Catenin/TCF Signaling in Neurons of the Adult Brain

(2013) Marta B. Wisniewska   NEUROCHEMICAL RESEARCH

Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling

(2013) Iolanda D'Alimonte et al.   Stem Cell Research

Wnt Signaling Behaves as a “Master Regulator” in the Osteogenic and Adipogenic Commitment of Human Amniotic Fluid Mesenchymal Stem Cells

(2013) Iolanda D’Alimonte et al.   Stem Cell Reviews and Reports

Embryonic stem cells neural differentiation qualifies the role of Wnt/β-Catenin signals in human telencephalic specification and regionalization

(2013) Camille Nicoleau et al.   STEM CELLS

Therapeutic Efficacy and Fate of Bimodal Engineered Stem Cells in Malignant Brain Tumors

(2013) Jordi Martinez-Quintanilla et al.   STEM CELLS

WNT signaling in neuronal maturation and synaptogenesis

(2013) Silvana B. Rosso et al.   Frontiers in Cellular Neuroscience

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

(2012) Daniel C. Berwick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

(2012) Ulf D. Kahlert et al.   CANCER LETTERS

FoxM1 and Wnt/ -Catenin Signaling in Glioma Stem Cells

(2012) A. Gong et al.   CANCER RESEARCH

Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model

(2012) Ananth K. Vellimana et al.   JOURNAL OF NEURO-ONCOLOGY

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

(2012) Daniel Picard et al.   LANCET ONCOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration

(2012) Charlotte E.J. Clark et al.   NEUROSIGNALS

Umbilical Cord Blood-Derived Mesenchymal Stem Cells Inhibit, But Adipose Tissue-Derived Mesenchymal Stem Cells Promote, Glioblastoma Multiforme Proliferation

(2012) Keiko Akimoto et al.   STEM CELLS AND DEVELOPMENT

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme

(2011) O. L. Chinot et al.   ADVANCES IN THERAPY

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation

(2011) X. Jin et al.   CANCER RESEARCH

The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis

(2011) Iris Augustin et al.   EMBO Molecular Medicine

All four zebrafish Wnt7 genes are expressed during early brain development

(2011) Carlo A. Beretta et al.   GENE EXPRESSION PATTERNS

β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma

(2011) Chunsheng Kang   INTERNATIONAL JOURNAL OF ONCOLOGY

Wnt Signaling Regulates Neuronal Differentiation of Cortical Intermediate Progenitors

(2011) R. N. Munji et al.   JOURNAL OF NEUROSCIENCE

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

(2011) W. Cerpa et al.   JOURNAL OF NEUROSCIENCE

Wnt activation is implicated in glioblastoma radioresistance

(2011) Yonghyun Kim et al.   LABORATORY INVESTIGATION

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

En1 and Wnt signaling in midbrain dopaminergic neuronal development

(2011) Maria TM Alves dos Santos et al.   Neural Development

The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence

(2011) Wanyu L. Lambiv et al.   NEURO-ONCOLOGY

The dynamic role of beta-catenin in synaptic plasticity

(2011) Kimberly A. Maguschak et al.   NEUROPHARMACOLOGY

Immunohistochemical Expression of Embryonic Stem Cell Markers in Malignant Rhabdoid Tumors

(2011) Jeremy Deisch et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

MSCs: Biological characteristics, clinical applications and their outstanding concerns

(2010) Yi-Ling Si et al.   AGEING RESEARCH REVIEWS

PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas

(2010) Hongwu Zheng et al.   CANCER CELL

Human Bone Marrow-Derived MSCs Can Home to Orthotopic Breast Cancer Tumors and Promote Bone Metastasis

(2010) R. H. Goldstein et al.   CANCER RESEARCH

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

(2010) E. Balzer et al.   DEVELOPMENT

The Wnt /β-catenin signaling pathway in the adult neurogenesis

(2010) Lin Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

The Imprinted GenePEG3Inhibits Wnt Signaling and Regulates Glioma Growth

(2010) Xiuli Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LEF1/ -Catenin Complex Regulates Transcription of the Cav3.1 Calcium Channel Gene (Cacna1g) in Thalamic Neurons of the Adult Brain

(2010) M. B. Wisniewska et al.   JOURNAL OF NEUROSCIENCE

Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons

(2010) L. Cuitino et al.   JOURNAL OF NEUROSCIENCE

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Cross-species genomics matches driver mutations and cell compartments to model ependymoma

(2010) Robert A. Johnson et al.   NATURE

Selective targeting of radiation-resistant tumor-initiating cells

(2010) Mei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas

(2009) Silke Götze et al.   INTERNATIONAL JOURNAL OF CANCER

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1

(2009) Y Zhu et al.   LEUKEMIA

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model

(2008) Ling Qiao et al.   CELL RESEARCH

Retromer Retrieves Wntless

(2008) Suzanne Eaton   DEVELOPMENTAL CELL

Cleavage of the Wnt Receptor Ryk Regulates Neuronal Differentiation during Cortical Neurogenesis

(2008) Jungmook Lyu et al.   DEVELOPMENTAL CELL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Regulation of Wnt protein secretion and its role in gradient formation

(2008) Kerstin Bartscherer et al.   EMBO REPORTS

Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy

(2008) David A Reardon et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Expression pattern of Wnt inhibitor factor 1(Wif1) during the development in mouse CNS

(2008) Yu-An Hu et al.   GENE EXPRESSION PATTERNS

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE