Article
Oncology
Shu Ning, Chengfei Liu, Wei Lou, Joy C. Yang, Alan P. Lombard, Leandro S. D'Abronzo, Neelu Batra, Ai-Ming Yu, Amy R. Leslie, Masuda Sharifi, Christopher P. Evans, Allen C. Gao
Summary: Next-generation antiandrogen drugs improve survival and quality of life in advanced prostate cancer patients, but resistance to these drugs is not well understood. This study found that the Wnt5a/FZD2 signaling pathway plays a critical role in promoting enzalutamide resistance, and targeting this pathway could be a potential therapy for advanced prostate cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Optics
Wenqi Shi, Lingbao Kong
Summary: This study proposes an adaptive multi-polarization illumination system to effectively eliminate specular highlights and ensure uniform illumination in light field microscopy imaging fields.
Article
Oncology
Shengchao Xu, Chengke Luo, Dikang Chen, Lu Tang, Quan Cheng, Ling Chen, Zhixiong Liu
Summary: The study aimed to elucidate the role and mechanism of circMMD in tumor treating fields (TTF) treatment of glioblastoma (GBM). The results showed that circMMD expression was elevated in GBM and high expression was associated with poor prognosis. TTF intervention reduced circMMD synthesis, suppressing GBM proliferation and increasing TTF-mediated apoptosis. The reduction of circMMD promoted the interaction between FUBP1 and FIR, leading to decreased DVL1 transcription. Additionally, decreased circMMD enhanced miR-15b-5p activity to degrade FZD6. Ultimately, the diminished expression of DVL1 and FZD6 suppressed the activation of Wnt/beta-catenin pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Computer Science, Information Systems
Zhu He, Mingwei Lin, Zeshui Xu, Zhiqiang Yao, Hong Chen, Adi Alhudhaif, Fayadh Alenezi
Summary: In this paper, a novel Deconv-Transformer (DecT) network model is proposed for histopathological image recognition of breast cancer. The model achieves good classification results by incorporating color deconvolution and self-attention mechanism, and effectively utilizes the staining properties of histopathological images by combining RGB and HED color space images. The DecT model demonstrates excellent performance on multiple datasets.
INFORMATION SCIENCES
(2022)
Article
Oncology
Dainan Zhang, Shunchang Ma, Chuanbao Zhang, Peiliang Li, Beibei Mao, Xiudong Guan, Wenjianlong Zhou, Jiayi Peng, Xi Wang, Shaomin Li, Wang Jia
Summary: MiR-935 is downregulated in human glioblastoma (GB) and directly inhibits the expression of FZD6 to suppress cell proliferation, suggesting its potential as a prognostic biomarker or therapeutic target in GB.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shoaib Ajaib, Disha Lodha, Steven Pollock, Gemma Hemmings, Martina A. Finetti, Arief Gusnanto, Aruna Chakrabarty, Azzam Ismail, Erica Wilson, Frederick S. Varn, Bethany Hunter, Andrew Filby, Asa A. Brockman, David McDonald, Roel G. W. Verhaak, Rebecca A. Ihrie, Lucy F. Stead
Summary: Researchers have developed a tool that can separate immune and neoplastic cells within the GBM tumor microenvironment from bulk RNA sequencing data. GBMdeconvoluteR accurately quantifies immune and neoplastic cell proportions in IDHwt GBM tumor samples.
Article
Medicine, General & Internal
Jeremy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Kevin Muller, Guillaume Pinna, Tim W. Failes, Greg M. Arndt, Philippe Morando, Nathalie Baeza-Kallee, Carole Colin, Olivier Chinot, Diane Braguer, Xavier Morelli, Nicolas Andre, Manon Carre, Emeline Tabouret, Dominique Figarella-Branger, Marion Le Grand, Eddy Pasquier
Summary: This study identified targetable vulnerabilities in glioblastoma using high-throughput screening, target deconvolution, and functional genomics. They validated the role of the top gene hit and discovered pharmacological synergisms through drug combination screens. The efficacy of the AURKA/BET inhibitor combination in glioblastoma was confirmed in pre-clinical models.
Article
Cell Biology
Xuming Zhu, Mingang Xu, N. Adrian Leu, Edward E. Morrisey, Sarah E. Millar
Summary: Human Robinow syndrome and dominant omodysplasia type 2 are caused by heterozygous mutations in the Wnt receptor FZD2, which is associated with skeletal limb and craniofacial defects. Through studying a mice model, it was found that FZD2 mutations caused limb shortening and disruption of Wnt signaling pathways. These findings reveal the pathogenic role of FZD2 mutations in RS and OMOD2 patients.
DISEASE MODELS & MECHANISMS
(2023)
Article
Engineering, Biomedical
Fernando Perez-Bueno, Juan G. Serra, Miguel Vega, Javier Mateos, Rafael Molina, Aggelos K. Katsaggelos
Summary: This study presents a blind color deconvolution framework based on Bayesian modeling and inference. By separating multi-stained images into single stained bands and normalizing the stain colors, the generalization error of computer aided diagnosis systems can be reduced.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2022)
Article
Environmental Sciences
Yue Lu, Ya Ke Liu, Fu Yin Wan, Song Shi, Ran Tao
Summary: This study demonstrated that CircSmg5 promotes BMSC osteogenic differentiation by targeting the miR-194-5p/Fzd6 axis to activate the Wnt/beta-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Carolina J. Garcia Garcia, Ariana C. Acevedo Diaz, Neeraj Kumari, Suman Govindaraju, Marimar de la Cruz Bonilla, F. Anthony San Lucas, Nicholas D. Nguyen, Iancarlos Jimenez Sacarello, Helen Piwnica-Worms, Anirban Maitra, Cullen M. Taniguchi
Summary: Research suggests that HIF2 provides gastrointestinal radioprotection by activating the expression of Wnt5a. Wnt5a plays a crucial role in crypt regeneration of intestinal stem cells and radioprotection of the gastrointestinal tract.
FRONTIERS IN ONCOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Fernando Perez-Bueno, Miguel Vega, Maria A. Sales, Jose Aneiros-Fernandez, Valery Naranjo, Rafael Molina, Aggelos K. Katsaggelos
Summary: This study proposes a framework for blind color deconvolution in digital histopathology to address color variations, leading to improved performance in normalization and cancer classification tasks. By separating multi-stained images into single stained bands, machine learning tasks can benefit from the enhanced fidelity and classification accuracy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Chemistry, Analytical
Wilson Phung, Corey E. E. Bakalarski, Trent B. B. Hinkle, Wendy Sandoval, Michael T. T. Marty
Summary: Recent advances in native and denatured intact protein mass spectrometry have made them essential for biotherapeutic characterization. This paper introduces the UniDec processing pipeline (UPP) for the analysis of batched biotherapeutic intact mass spectrometry data, providing fast processing, deconvolution, and peak detection. The UPP offers a flexible workflow that can be easily customized and applied to a wide range of biotherapeutic applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Jun Cheng, Kaidre Bendjama, Karola Rittner, Brandon Malone
Summary: This study introduces a transformer neural network model that leverages self-supervised pretraining and a multiple instance learning framework to improve the prediction performance of peptide-MHC binding and presentation. The combination of pretraining and the novel MIL approach outperforms state-of-the-art models for both tasks.
Article
Computer Science, Information Systems
Yizhong Wang, Penghui Niu, Xiaoyong Guo, Guowei Yang, Jun Chen
Summary: This paper introduces a deconvolutional region magnification procedure in SSD to improve the accuracy of small and medium object detections. By constructing a new feature pyramid on top of the existing SSD layers and using a pre-training-retraining strategy, the model demonstrates significantly better performance in detecting small and medium objects compared to traditional SSD.
Article
Multidisciplinary Sciences
Jae-Sook Park, Simon Halegoua, Shosei Kishida, Aaron M. Neiman
Article
Oncology
Takeshi Harada, Hideki Yamamoto, Shosei Kishida, Michiko Kishida, Chihiro Awada, Toshifumi Takao, Akira Kikuchi
Article
Pharmacology & Pharmacy
Ayana Yoshinaga, Natsuki Kajiya, Kazuki Oishi, Yuko Kamada, Asami Ikeda, Petros Kingstone Chigwechokha, Toshiro Kibe, Michiko Kishida, Shosei Kishida, Masaharu Komatsu, Kazuhiro Shiozaki
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Oncology
Muzafar A. Macha, Satyanarayana Rachagani, Asif Khurshid Qazi, Rahat Jahan, Suprit Gupta, Anery Patel, Parthasarathy Seshacharyulu, Chi Lin, Sicong Li, Shuo Wang, Vivek Verma, Shosei Kishida, Michiko Kishida, Norifumi Nakamura, Toshiro Kibe, William M. Lydiatt, Russell B. Smith, Apar K. Ganti, Dwight T. Jones, Surinder K. Batra, Maneesh Jain
Article
Biochemistry & Molecular Biology
Takao Fuchigami, Hirofumi Koyama, Michiko Kishida, Yoshiaki Nishizawa, Mikio Iijima, Toshiro Kibe, Masahiro Ueda, Tohru Kiyono, Yoshimasa Maniwa, Norifumi Nakamura, Shosei Kishida
Article
Immunology
Megumi Matsumoto, Taisei Kubota, Sinsuke Fujita, Kazuhiro Shiozaki, Shosei Kishida, Atsushi Yamamoto
INFECTION AND IMMUNITY
(2019)
Article
Toxicology
Ripon Sarkar, Shosei Kishida, Michiko Kishida, Norifumi Nakamura, Toshiro Kibe, Deepmala Karmakar, Chirasree Roy Chaudhuri, Ananya Barui
TOXICOLOGY IN VITRO
(2019)
Article
Medicine, Research & Experimental
Shinsuke Fujii, Yudai Tajiri, Kana Hasegawa, Shinji Matsumoto, Reiko U. Yoshimoto, Hiroko Wada, Shosei Kishida, Mizuho A. Kido, Hiromasa Yoshikawa, Satoru Ozeki, Tamotsu Kiyoshima
LABORATORY INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Aiko Takano, Taiki Sanada, Misaki Iwashita, Takanori Shinjo, Takao Fukuda, Terukazu Sanui, Shosei Kishida, Fusanori Nishimura
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Sharon C. Hook, Alexandra Chadt, Kate J. Heesom, Shosei Kishida, Hadi Al-Hasani, Jeremy M. Tavare, Elaine C. Thomas
SCIENTIFIC REPORTS
(2020)
Article
Toxicology
Carmen S. Tellez, Daniel E. Juri, Loryn M. Phillips, Kieu Do, Christin M. Yingling, Cindy L. Thomas, Wendy W. Dye, Guodong Wu, Shosei Kishida, Tohru Kiyono, Steven A. Belinsky
Summary: The study evaluated the cytotoxicity and genotoxicity of different flavored e-liquids on oral epithelial cells, finding that some liquids caused significant increases in cell toxicity and oxidative stress levels, as well as genotoxicity.
TOXICOLOGICAL SCIENCES
(2021)
Review
Dentistry, Oral Surgery & Medicine
Takao Fuchigami, Yusuke Ono, Shosei Kishida, Norifumi Nakamura
Summary: Ameloblastoma is a benign odontogenic tumor that often invades surrounding bone aggressively and has a high recurrence rate. Despite the lack of innovative treatments, recent molecular biological findings point to potential new therapeutic methods, such as molecular targeted therapy.
JAPANESE DENTAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Elissa Chairani, Takao Fuchigami, Hirofumi Koyama, Yusuke Ono, Mikio Iijima, Michiko Kishida, Toshiro Kibe, Norifumi Nakamura, Shosei Kishida
Summary: This study investigated the interactions between ameloblastoma cells and osteoblasts. The results showed that ameloblastoma cells can induce inflammatory cytokine production in osteoblasts, and osteoblasts can accelerate the proliferation and migration activity of ameloblastoma cells. These intercellular signalings between the two cell types may play multiple roles in the pathogenesis of ameloblastoma.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Takao Fuchigami, Hajime Suzuki, Takuya Yoshimura, Toshiro Kibe, Elissa Chairani, Tohru Kiyono, Michiko Kishida, Shosei Kishida, Norifumi Nakamura
JOURNAL OF APPLIED ORAL SCIENCE
(2020)
Article
Endocrinology & Metabolism
Miki Nonaka, Nagomi Kurebayashi, Takashi Murayama, Masami Sugihara, Kiyoshi Terawaki, Seiji Shiraishi, Kanako Miyano, Hiroshi Hosoda, Shosei Kishida, Kenji Kangawa, Takashi Sakurai, Yasuhito Uezono
