Journal
GENE EXPRESSION PATTERNS
Volume 8, Issue 7-8, Pages 515-522Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gep.2008.06.001
Keywords
Wif1; Wnt; Telencephalon; Cortex; Hippocampus; Cortical hem; Diencephalon; Midbrain; Cerebellum; Spinal cord; Expression pattern; Mouse
Categories
Funding
- National Nature Science Foundation of China [30770696, 30525017]
- The Ministry of Education of China [106083]
- National Basic Research Program of China [2007CB512303]
- The Ministry of Science and Technology of China
Ask authors/readers for more resources
Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins. Here we describe the expression pattern of Wif1 throughout the development of the Mouse central nervous system (CNS). Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. In embryonic stages, the level of Wif1 expression Was Very prominent in several areas including the cerebral Cortex, the diencephalon and the midbrain, with the strongest level in the hippocampal plate and the diencephalon. However, after birth, the expression level of Wif1 decreased in the cortex and diencephalon. By adulthood, Wif1 is mainly expressed in the medial habenular nucleus (MHb) in the epithalamus, the mitral layer cells in the olfactory bulb and a few nuclei in the hypothalamus. Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that Wif1 may play an essential role in the spatial and temporal regulation of Wnt signals. (C) 2008 Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available