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Medicine, Research & Experimental
Cecily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V. Pandey, Pierre Val, Florence Roucher-Boulez, Christa E. Flueck
Summary: This article describes a highly consanguineous family with multiple perinatal deaths and infants presenting at birth with failure to thrive, severe salt-wasting crises associated with isolated hypoaldosteronism, nail anomalies, short stature, and deafness. Whole exome sequencing revealed a homozygous splice variant in the R-SPONDIN receptor LGR4 gene (c.618-1G>C) regulating WNT signaling. The impact of LGR4 inactivation was analyzed by adrenal cortex-specific ablation of Lgr4, which resulted in abnormal zG differentiation and endocrine function.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Bei Tao, Yi Song, Yao Wu, Xiaobo Yang, Tangming Peng, Lilei Peng, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Chuanhong Zhong
Summary: This study found that a stiffer matrix can promote the stemness of glioma cells by activating the BCL9L/Wnt/beta-catenin signaling pathway. Additionally, gigantol can enhance the effectiveness of traditional chemotherapy and radiotherapy by inhibiting Wnt/beta-catenin signaling, providing a potential strategy for clinical treatment of gliomas.
Article
Biochemistry & Molecular Biology
Hyeyoon Lee, Rui Sun, Christof Niehrs
Summary: Bone morphogenetic proteins (BMPs) play important roles in various biological processes, including embryogenesis and disease. Recent studies have found that R-spondin 2 (RSPO2) acts as a BMP receptor antagonist, and a peptide derived from RSPO2 can uncouple BMP antagonist function from WNT agonist function, showing potential for therapeutic development in diseases like acute myeloid leukemia (AML). By using a dendrimer based on this peptide, it is possible to selectively target BMP receptor signaling, reduce cell growth, and induce differentiation in AML cells, as well as modulate embryonic patterning in Xenopus embryos.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Zong-qing Zhao, Xiu-jie Wu, Yan-hao Cheng, Yun-fei Zhou, Xi-meng Ma, Jian Zhang, Xue-yuan Heng, Fan Feng
Summary: The study demonstrated that TROAP plays an oncogenic role in glioma by activating the Wnt/beta-Catenin signaling pathway, leading to cell proliferation, migration, invasion, and poor prognosis. Inhibition of TROAP or downstream targets of Wnt/beta-Catenin pathway could reverse the tumor-promoting effects, suggesting TROAP as a potential novel target for glioma therapy.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Qingjiu Zhou, Qiang Fu, Mahati Shaya, Yalikun Kugeluke, Shaoshan Li, Yisireyili Dilimulati
Summary: This study found that circ_CAPG (circ_0055412) contributes to cisplatin resistance in glioma cells by stabilizing CAPG mRNA and modulating the Wnt/beta-catenin signaling pathway, providing new information for the treatment of glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
San-Zhong Liu, Kai-Xi Ren, Jing Zhao, Shuang Wu, Juan Li, Jian Zang, Zhou Fei, Jun-Long Zhao
Summary: The study revealed that miR-139 and its host gene PDE2A have anti-tumor effects in glioblastomas by regulating GSC stemness. PDE2A and miR-139 modulate GSC characteristics through the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Environmental Sciences
Anna Smirnova, Anna Mentor, Petter Ranefall, Carl-Gustaf Bornehag, Bjorn Brunstrom, Anna Mattsson, Maria Jonsson
Summary: Experimental studies on chemical mixture G in zebrafish models showed increased apoptosis, suppressed Wnt/β-catenin signaling, and altered caudal fin shape, suggesting potential adverse health effects from pollutant mixtures interfering with developmental processes.
Article
Hematology
Antonina Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J. P. Dijkgraaf, Elaine E. Storm, Noelyn M. Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Herault, Andrew Mancini, Hartmut Koeppen, Monique Dail, Qingxiang Yan, Jianhuan Zhang, Ute Koch, Freddy Radtke, Zora Modrusan, Ciara Metcalfe, Robert Piskol, Frederic J. de Sauvage
Summary: The self-renewal and differentiation of stem and progenitor cells are regulated by systemic and local cues. RSPO3 is important for Wnt signaling and is usually expressed in the stem cell niche to regulate stem cell expansion and differentiation. Disrupting the niche-restricted expression of RSPO3 can affect tissue organization and lead to disorders and cancers.
Article
Oncology
Shize Ma, Lei Duan, Huateng Dong, Xiaodong Ma, Xinyu Guo, Jianli Liu, Guoqiang Li, Yue Yu, Yanlong Xu, Guoqiang Yuan, Xingkun Zhao, Guopeng Tian, Shijia Zhai, Yawen Pan, Yinian Zhang
Summary: OLFML2A is identified as a key promotor of gliomagenesis, with its expression significantly upregulated in glioma specimens and correlating with pathological grades. Knockdown of OLFML2A inhibits cell proliferation and promotes apoptosis in glioma cells by suppressing Wnt/beta-catenin signaling. Additionally, downregulation of OLFML2A suppresses growth of transplanted glioma by inhibiting Wnt/beta-catenin pathway-dependent cell proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Jimin Han, Kaijun Lin, Xuezheng Zhang, Lingchen Yan, Jianjun Liu, Jia Liu
Summary: The study revealed the significant impact of PTEN and β-catenin on the proliferation of Lgr5+ hepatocytes, providing insights into the regulation of Lgr5+ hepatocyte proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Neurosciences
Maisa I. Alkailani, Mohamed Aittaleb, Fadel Tissir
Summary: Neurogenesis and tumorigenesis share common signaling molecules and pathways involved in cell proliferation, differentiation, migration, and death. Abnormalities in these molecular mechanisms can lead to tumor formation and progression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Biochemistry & Molecular Biology
Yan-Qing Fei, Ru-Ting Shi, Yang-Fan Zhou, Jin-Ze Wu, Zhi Song
Summary: Mannose inhibits glioma cell growth and enhances sensitivity to TMZ, possibly through the inhibition of MGMT and activation of the Wnt/beta-catenin pathway.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Dandan Feng, Jiang Li, Liang Guo, Jing Liu, Shaochen Wang, Xiuyuan Ma, Yunxuan Song, Ju Liu, Enkui Hao
Summary: This study demonstrates that DDX3X plays a protective role in Dox-induced cardiotoxicity by activating the Wnt/beta-catenin signaling pathway. This finding contributes to a better understanding of the pathogenesis of DIC and provides a new target for the development of cardiac protective therapies.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)