Article
Plant Sciences
Weijia Zhang, Chang Peng, Jiahui Yan, Pengting Chen, Cheng Jiang, Shuyi Sang, Yuemei Yuan, Yanjun Hong, Meicun Yao
Summary: This study demonstrated that the aqueous extract of Sanguisorba officinalis Linn. could inhibit the growth and metastasis of colorectal cancer cells by suppressing the Wnt pathway, providing potential for clinical application as an anti-CRC drug.
Article
Medicine, Research & Experimental
Yong-Qiang Hua, Ke Zhang, Jie Sheng, Zhou-Yu Ning, Ye Li, Wei-Dong Shi, Lu-Ming Liu
Summary: The study revealed that Fam83D is overexpressed in pancreatic adenocarcinoma and associated with clinical features and patient outcomes. Knockdown of Fam83D inhibited proliferation, suppressed metabolism, and increased sensitivity to gemcitabine in PDAC cells.
Article
Plant Sciences
Chuan Li, Liru Tian, Yihai Wang, Huan Luo, Jia Zeng, Peiqiang Su, Shulin Chen, Zhiheng Liao, Weimin Guo, Xiangjiu He, Shuqing Chen, Caixia Xu
Summary: The study showed that M13 promotes the proliferation and osteogenic differentiation of MSCs by activating the Wnt/β-catenin pathway. This finding provides new evidence to support the use of Morinda officinalis for the treatment of osteoporosis.
Article
Biochemistry & Molecular Biology
Zengli Liu, Jialiang Liu, Tianli Chen, Yue Wang, Anda Shi, Kangshuai Li, Xingyong Li, Bo Qiu, Lijie Zheng, Liming Zhao, Lizhuang Shu, Shuo Lian, Shaohui Huang, Zongli Zhang, Yunfei Xu
Summary: Cholangiocarcinoma (CCA) is a highly malignant tumor originating from bile ducts. This study identified SOX9 and FGF7 as prognostic biomarkers of CCA and demonstrated that the WNT3A-TCF7-SOX9 axis can induce pemigatinib resistance through two independent pathways.
Article
Biochemistry & Molecular Biology
Min-Chieh Hsin, Yi-Hsuan Hsiao, Pei-Ni Chen, Chiao-Wen Lin, Po-Hui Wang, Shun-Fa Yang, Chung-Yuan Lee
Summary: DHM inhibits cell migration in human cervical cancer cell lines by reducing S100A4 expression and regulating the ERK1/2/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mai Barakat, Abdelaziz M. Hussein, Mohamed F. Salama, Amira Awadalla, Nashwa Barakat, Mohamed Serria, Mohamed El-Shafey, Mohamed El-Sherbiny, Mohamed A. El Adl
Summary: The study found that pretreating Wharton jelly mesenchymal stem cells (WJ-MSCs) with all-trans-retinoic acid (ATRA) has a protective effect on renal ischemia in rats. This effect may be achieved through upregulation of the beta-catenin/Wnt pathway and attenuation of apoptosis, inflammation, and oxidative stress.
Review
Cell Biology
Elisa Lozano, Paula Sanchon-Sanchez, Ana Morente-Carrasco, Luis Miguel Chinchilla-Tabora, Jose L. Mauriz, Paula Fernandez-Palanca, Jose J. G. Marin, Rocio I. R. Macias
Summary: The poor prognosis of advanced cholangiocarcinoma (CCA) presents a significant challenge in modern oncology due to increasing incidence and late diagnosis. The heterogeneity of CCA subtypes and complex mechanisms involved in CCA contribute to the difficulty in treating this deadly tumor. The Wnt/beta-catenin pathway plays a crucial role, and understanding its alteration in relation to the heterogeneous forms of CCA is essential for advancing diagnostic and therapeutic strategies.
Article
Oncology
Chunhui Lai, Ningyu He, Jianghui Zeng, Cuizhen Long, Mingfang Shi, Junguo Li, Shengjun Ma, Yu Xiong, Xiuyun Liang
Summary: This study investigates the effects of miR-144-3p on the proliferation, migration, and invasion of colon carcinoma cells by targeting SFRP1 and activating the Wnt/beta-catenin signaling pathway. The results suggest that miR-144-3p enhances the malignant behavior of colon carcinoma cells and could be a potential diagnostic and therapeutic target for colon carcinoma.
Article
Environmental Sciences
Jing Yang, Wenqing Bao, Haiyan Diao, Shaofei Yang, Lin Qiu, Chunjing Xu, Bin Zhao
Summary: This study reveals that TRIM29 is overexpressed in cholangiocarcinoma cells and promotes the malignancy of cholangiocarcinoma through the activation of MAPK and beta-catenin pathways. It suggests that TRIM29 may serve as an auxiliary indicator for innovative treatment strategies for cholangiocarcinoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhibao Zheng, Na Luan, Kai Tu, Feiyan Liu, Jianwei Wang, Jianguo Sun
Summary: PCDH7 expression in colorectal cancer cells is positively correlated with cell proliferation and drug resistance, while negatively correlated with cell migration and invasion. PCDH7 mediates drug resistance by inhibiting cell apoptosis through upregulating Mcl-1 expression and activating the Wnt signaling pathway. The Mcl-1 inhibitor S63845 can attenuate the anti-apoptotic effect of PCDH7 and sensitizes PCDH7-overexpressing colorectal cancer cells to ABT-263.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi, Zaffar Amin Shah
Summary: TGF-beta serves as a dual role in tumor progression, acting both as a tumor suppressor in the early stages and a metastatic promoter in the later stages. The signaling pathways of TGF-beta are complex, involving both SMAD-dependent and SMAD-independent pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Qinghua Liu, Lixin He, Siqi Li, Fengyan Li, Guangzheng Deng, Xinjian Huang, Muwen Yang, Yunyun Xiao, Xiangfu Chen, Ying Ouyang, Jinxin Chen, Xuxia Wu, Xi Wang, Libing Song, Chuyong Lin
Summary: This study reveals that HOMER3 is selectively overexpressed in the aggressive triple negative breast cancer subtype and is associated with earlier tumor metastasis and shorter patient survival. Mechanistically, HOMER3 interacts with c-Src and beta-Catenin to promote beta-Catenin tyrosine phosphorylation, leading to its nuclear translocation and activation. HOMER3 is essential for EGF-induced aggressiveness and metastasis of triple negative breast cancer cells both in vitro and in vivo.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Cell & Tissue Engineering
Junhou Lu, Yu Zhang, Dongyan Wang, Xiaojing Xu, Jianwei Xu, Xinyu Yang, Hongxiang Qian, Huanxiang Zhang
Summary: Migration of mesenchymal stem cells (MSCs) to injury sites is important in transplantation therapy. This study found that basic fibroblast growth factor (bFGF) promotes MSC migration through glycolysis, and specifically through the activation of hexokinase 2 (HK2) expression. Inhibition of glycolysis, but not oxidative phosphorylation, hindered the bFGF-induced migration of MSCs. Furthermore, bFGF regulated beta-catenin signaling through glycolytic intermediates, and transplantation with HK2-overexpressing MSCs improved cell therapy effectiveness on skull injury in rats.
Article
Biochemistry & Molecular Biology
Yajun Wei, Wei Chen, Zihan Li, Kun Xie, Fubao Liu
Summary: This study found that the expression level of EIF3H is significantly increased in iCCA tissues and cell lines. EIF3H promotes proliferation and migration of iCCAs, inhibiting apoptosis of iCCA cells by stabilizing the CCND1 protein structure. These findings provide insights into the mechanism of tumorigenesis role of EIF3H in iCCAs and a potential therapeutic target for iCCA treatment.
Article
Biotechnology & Applied Microbiology
Ran Ji, Yifei Ji, Lin Ma, Sijia Ge, Jing Chen, Shuzhen Wu, Tianxin Huang, Yu Sheng, Liyang Wang, Nan Yi, Zhaoxiu Liu
Summary: The study revealed that high expression of KRT17 can promote cell metastasis and angiogenesis of colon cancer cells by regulating the WNT/beta-catenin signaling pathway, indicating KRT17 as a potential therapeutic target for COAD treatment.