The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer

(2017) Nicole M. Fletcher et al.   FREE RADICAL BIOLOGY AND MEDICINE

PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity

(2017) Emi Y. Tokuda et al.   Integrative Biology

Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy

(2017) Yadong Tang et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Cancer: A precision approach to tumour treatment

(2017) Rodrigo Dienstmann et al.   NATURE

In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

(2017) Jatin Roper et al.   NATURE BIOTECHNOLOGY

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

(2017) Kevin P O'Rourke et al.   NATURE BIOTECHNOLOGY

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

(2017) Michelle B Chen et al.   Nature Protocols

Opportunities and challenges in phenotypic drug discovery: an industry perspective

(2017) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer

(2017) Cunxi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

(2017) Alba Cristobal et al.   Cell Reports

Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures

(2017) Sasha Cai Lesher-Pérez et al.   Biomaterials Science

Bringing 3D tumor models to the clinic - predictive value for personalized medicine

(2017) Kathrin Halfter et al.   Biotechnology Journal

Engineering the pre-metastatic niche

(2017) Brian A. Aguado et al.   Nature Biomedical Engineering

Ex vivo treatment of patient biopsies as a novel method to assess colorectal tumour response to the MEK1/2 inhibitor, Selumetinib

(2017) Sonia M. Novo et al.   Scientific Reports

A double-network poly(Nɛ-acryloyl l-lysine)/hyaluronic acid hydrogel as a mimic of the breast tumor microenvironment

(2016) Weijun Xu et al.   Acta Biomaterialia

In vitro cancer cell–ECM interactions inform in vivo cancer treatment

(2016) Andrew W. Holle et al.   ADVANCED DRUG DELIVERY REVIEWS

Real-time imaging of cancer cell chemotaxis in paper-based scaffolds

(2016) Rachael M. Kenney et al.   ANALYST

Biomimetic Hydrogels Incorporating Polymeric Cell-Adhesive Peptide To Promote the 3D Assembly of Tumoroids

(2016) Ying Hao et al.   BIOMACROMOLECULES

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

(2016) Sylvia Herter et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

(2016) Ran Li et al.   CANCER RESEARCH

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Fibroblast activation in cancer: when seed fertilizes soil

(2016) Sanya-Eduarda Kuzet et al.   CELL AND TISSUE RESEARCH

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer

(2016) Maija P. Valta et al.   CLINICAL & EXPERIMENTAL METASTASIS

Microfluidic models for adoptive cell-mediated cancer immunotherapies

(2016) Giulia Adriani et al.   DRUG DISCOVERY TODAY

Self-assembly of vascularized tissue to support tumor explants in vitro

(2016) Despina Bazou et al.   Integrative Biology

Impact of multicellular tumor spheroids as an in vivo-like tumor model on anticancer drug response

(2016) BIANCA GALATEANU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture

(2016) Shantanu Pradhan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Tumor stroma-containing 3D spheroid arrays: A tool to study nanoparticle penetration

(2016) Dwi L. Priwitaningrum et al.   JOURNAL OF CONTROLLED RELEASE

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Genomic evolution and chemoresistance in germ-cell tumours

(2016) Amaro Taylor-Weiner et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

A recellularized human colon model identifies cancer driver genes

(2016) Huanhuan Joyce Chen et al.   NATURE BIOTECHNOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

(2016) Olga A Guryanova et al.   NATURE MEDICINE

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

(2016) Emma Nolan et al.   NATURE MEDICINE

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

(2016) Daniela Loessner et al.   Nature Protocols

Personalized in vitro cancer models to predict therapeutic response: Challenges and a framework for improvement

(2016) Molly M. Morgan et al.   PHARMACOLOGY & THERAPEUTICS

Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology

(2016) Jeonghun Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

(2016) Jae-Won Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biofabrication of 3D Alginate-Based Hydrogel for Cancer Research: Comparison of Cell Spreading, Viability, and Adhesion Characteristics of Colorectal HCT116 Tumor Cells

(2016) Jelena Ivanovska et al.   TISSUE ENGINEERING PART C-METHODS

Understanding the Genetic Mechanisms of Cancer Drug Resistance Using Genomic Approaches

(2016) Xueda Hu et al.   TRENDS IN GENETICS

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids

(2016) Thierry Jardé et al.   Nature Communications

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

(2016) Thomas M. Ashton et al.   Nature Communications

Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma

(2016) Atsushi Takai et al.   Scientific Reports

Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment

(2016) Danh Truong et al.   Scientific Reports

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

(2016) Carla S Verissimo et al.   eLife

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

(2016) Jack W. Scannell et al.   PLoS One

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Engineering a 3D microfluidic culture platform for tumor-treating field application

(2016) Andrea Pavesi et al.   Scientific Reports

Quantitative Study of Cell Invasion Process under Extracellular Stimulation of Cytokine in a Microfluidic Device

(2016) Kin Fong Lei et al.   Scientific Reports

A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior

(2016) Laila C. Roudsari et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Quantifying oxygen in paper-based cell cultures with luminescent thin film sensors

(2015) Matthew W. Boyce et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Microfluidic Multiculture Assay to Analyze Biomolecular Signaling in Angiogenesis

(2015) Ashleigh B. Theberge et al.   ANALYTICAL CHEMISTRY

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

A paper-based invasion assay: Assessing chemotaxis of cancer cells in gradients of oxygen

(2015) Bobak Mosadegh et al.   BIOMATERIALS

High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment

(2015) Yukie Yoshii et al.   BIOMATERIALS

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure

(2015) Lauren L Bischel et al.   BMC CANCER

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial–mesenchymal transition in vitro

(2015) Sun-Ah Kim et al.   EXPERIMENTAL CELL RESEARCH

A novel 3D high-content assay identifies compounds that prevent fibroblast invasion into tissue surrogates

(2015) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

(2015) Choong Kim et al.   LAB ON A CHIP

An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells

(2015) Xue-Ying Wang et al.   LAB ON A CHIP

A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients

(2015) Darren Rodenhizer et al.   NATURE MATERIALS

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition

(2015) Jennifer L. Leight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogel-laden paper scaffold system for origami-based tissue engineering

(2015) Su-Hwan Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global analysis of phosphoproteome dynamics in embryonic development of zebrafish (Danio rerio)

(2015) Oh Kwang Kwon et al.   PROTEOMICS

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

(2015) Bo Ri Seo et al.   Science Translational Medicine

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

(2015) Biswanath Majumder et al.   Nature Communications

In vivo capture and label-free detection of early metastatic cells

(2015) Samira M. Azarin et al.   Nature Communications

High-Throughput Cancer Cell Sphere Formation for Characterizing the Efficacy of Photo Dynamic Therapy in 3D Cell Cultures

(2015) Yu-Chih Chen et al.   Scientific Reports

LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels

(2015) José A. Jiménez-Torres et al.   Advanced Healthcare Materials

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

(2015) Jeremy D. Caplin et al.   Advanced Healthcare Materials

Fibroblasts Enhance Migration of Human Lung Cancer Cells in a Paper-Based Coculture System

(2015) Gulden Camci-Unal et al.   Advanced Healthcare Materials

Peptide Hydrogels – Versatile Matrices for 3D Cell Culture in Cancer Medicine

(2015) Peter Worthington et al.   Frontiers in Oncology

Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA

(2015) Zheng Lao et al.   PLoS One

Microfluidic 3D models of cancer

(2014) Kyung Eun Sung et al.   ADVANCED DRUG DELIVERY REVIEWS

Human decellularized adipose tissue scaffold as a model for breast cancer cell growth and drug treatments

(2014) Lina W. Dunne et al.   BIOMATERIALS

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance

(2014) Chang Seok Ki et al.   BIOMATERIALS

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems

(2014) Jessie S. Jeon et al.   Integrative Biology

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

A multilayered cell culture model for transport study in solid tumors: Evaluation of tissue penetration of polyethyleneimine based cationic micelles

(2014) Seiji Miura et al.   Nano Today

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Single luminal epithelial progenitors can generate prostate organoids in culture

(2014) Chee Wai Chua et al.   NATURE CELL BIOLOGY

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of an Acellular Tumor Extracellular Matrix as a Three-Dimensional Scaffold for Tumor Engineering

(2014) Wei-Dong Lü et al.   PLoS One

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics

(2014) Meenakshi Upreti et al.   Translational Oncology

Resolving cancer–stroma interfacial signalling and interventions with micropatterned tumour–stromal assays

(2014) Keyue Shen et al.   Nature Communications

Cancer-driven dynamics of immune cells in a microfluidic environment

(2014) Elena Agliari et al.   Scientific Reports

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

(2014) Jean Albrengues et al.   Cell Reports

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

(2014) Mariam Jamal-Hanjani et al.   PLOS BIOLOGY

Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions

(2014) Kyle Carver et al.   Molecular Therapy-Nucleic Acids

Engineered Culture Models for Studies of Tumor-Microenvironment Interactions

(2013) David W. Infanger et al.   Annual Review of Biomedical Engineering

Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid

(2013) Sara Pedron et al.   BIOMATERIALS

A microfluidic device for uniform-sized cell spheroids formation, culture, harvesting and flow cytometry analysis

(2013) Bishnubrata Patra et al.   Biomicrofluidics

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

(2013) D C Swinney   CLINICAL PHARMACOLOGY & THERAPEUTICS

Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology

(2013) Bartley J. Gill et al.   JOURNAL OF BIOMECHANICS

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients

(2013) Brendon M. Baker et al.   LAB ON A CHIP

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Formation of microvascular networks in vitro

(2013) John P Morgan et al.   Nature Protocols

Adipocytes: Impact on tumor growth and potential sites for therapeutic intervention

(2013) Simona Hefetz-Sela et al.   PHARMACOLOGY & THERAPEUTICS

Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device

(2013) Shanshan Wang et al.   PLoS One

Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha

(2013) Jennifer Adamski et al.   PLoS One

Development of a High-Throughput Three-Dimensional Invasion Assay for Anti-Cancer Drug Discovery

(2013) Nikki A. Evensen et al.   PLoS One

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

(2013) E. L. S. Fong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease

(2013) S. Goel et al.   Cold Spring Harbor Perspectives in Medicine

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Evaluation of interstitial protein delivery in multicellular layers model

(2012) Soo-Yeon Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model

(2012) B. J. Gill et al.   CANCER RESEARCH

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro cell migration and invasion assays

(2012) Nina Kramer et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

A decade of change

(2012) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

A Heterogeneous In Vitro Three Dimensional Model of Tumour-Stroma Interactions Regulating Sprouting Angiogenesis

(2012) Pedro Correa de Sampaio et al.   PLoS One

Matrix Rigidity Regulates Cancer Cell Growth by Modulating Cellular Metabolism and Protein Synthesis

(2012) Robert W. Tilghman et al.   PLoS One

Integrating Macrophages into Organotypic Co-Cultures: A 3D In Vitro Model to Study Tumor-Associated Macrophages

(2012) Nina Linde et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles

(2012) Don N. Ho et al.   Theranostics

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Modeling Colon Adenocarcinomas in Vitro

(2011) Helmut Dolznig et al.   AMERICAN JOURNAL OF PATHOLOGY

Three-dimensional porous silk tumor constructs in the approximation of in vivo osteosarcoma physiology

(2011) Pamela H.S. Tan et al.   BIOMATERIALS

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

(2011) Amy Y. Hsiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

Randomized Phase II Trials: A Long-term Investment With Promising Returns

(2011) M. R. Sharma et al.   JNCI-Journal of the National Cancer Institute

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Multizone Paper Platform for 3D Cell Cultures

(2011) Ratmir Derda et al.   PLoS One

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Chitosan–alginate 3D scaffolds as a mimic of the glioma tumor microenvironment

(2010) Forrest M. Kievit et al.   BIOMATERIALS

Dissecting Variability in Responses to Cancer Chemotherapy Through Systems Pharmacology

(2010) R Yang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Decellularized matrices for tissue engineering

(2010) Takashi Hoshiba et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

(2010) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia

(2010) Todd W Ridky et al.   NATURE MEDICINE

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals

(2010) Choi   ONCOLOGY REPORTS

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

(2010) V. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

Paper-supported 3D cell culture for tissue-based bioassays

(2009) R. Derda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Formation and activation of fibroblast spheroids depend on fibronectin–integrin interaction

(2008) Pertteli Salmenperä et al.   EXPERIMENTAL CELL RESEARCH

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells

(2008) Ilya Serebriiskii et al.   MATRIX BIOLOGY

Zebrafish as a Cancer Model

(2008) H. Feitsma et al.   MOLECULAR CANCER RESEARCH