RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

The Role of Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer

(2016) Lynn C. Hartmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Breast Cancer Risk After Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers: Revisiting the Evidence for Risk Reduction

(2015) B. A. M. Heemskerk-Gerritsen et al.   JNCI-Journal of the National Cancer Institute

Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial

(2015) Michael Gnant et al.   LANCET

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

(2015) Nai Yang Fu et al.   NATURE CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence

(2015) Maja Sedic et al.   Nature Communications

Breast Cancer Risk After Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers: Revisiting the Evidence for Risk Reduction

(2015) B. A. M. Heemskerk-Gerritsen et al.   JNCI-Journal of the National Cancer Institute

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1

(2015) Purna A. Joshi et al.   Stem Cell Reports

The PARP Inhibitors, Veliparib and Olaparib, Are Effective Chemopreventive Agents for Delaying Mammary Tumor Development in BRCA1-deficient Mice

(2014) C. To et al.   Cancer Prevention Research

Breast cancer prevention for BRCA1 and BRCA2 mutation carriers: is there a role for tamoxifen?

(2014) Kelly-Anne Phillips et al.   Future Oncology

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

(2014) A. R. Venkitaraman   SCIENCE

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study

(2013) Martin Widschwendter et al.   LANCET ONCOLOGY

The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote

(2013) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

(2013) T. Tanos et al.   Science Translational Medicine

Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis

(2013) Pasquale Pellegrini et al.   STEM CELLS

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

(2013) Bhupinder Pal et al.   Cell Reports

Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

(2012) D. G. Branstetter et al.   CLINICAL CANCER RESEARCH

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

(2011) Theresa A. Proia et al.   Cell Stem Cell

From the ranks of mammary progesterone mediators, RANKL takes the spotlight

(2011) Rodrigo Fernandez-Valdivia et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

(2011) S. R. Oakes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal Cells

(2011) Peter Eirew et al.   STEM CELLS

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality

(2010) Susan M. Domchek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Control of mammary stem cell function by steroid hormone signalling

(2010) Marie-Liesse Asselin-Labat et al.   NATURE

Progesterone induces adult mammary stem cell expansion

(2010) Purna A. Joshi et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland

(2010) M. Beleut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL*

(2008) Paul J Kostenuik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability

(2008) Peter Eirew et al.   NATURE MEDICINE

BRCA1 regulates human mammary stem/progenitor cell fate

(2008) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA