PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

3D Biomimetic Cultures: The Next Platform for Cell Biology

(2016) Christopher S. Chen   TRENDS IN CELL BIOLOGY

The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels

(2015) Manav Mehta et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition

(2015) Jennifer L. Leight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deconstructing Signaling in Three Dimensions

(2014) Matthew G. Rubashkin et al.   BIOCHEMISTRY

Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness

(2014) Emi Y. Tokuda et al.   BIOMATERIALS

The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation

(2014) Sarah T. Gould et al.   BIOMATERIALS

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

(2014) Chong Sun et al.   NATURE

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density

(2013) Kyle A. Kyburz et al.   Acta Biomaterialia

Emerging insights into resistance to BRAF inhibitors in melanoma

(2013) Amanda D. Bucheit et al.   BIOCHEMICAL PHARMACOLOGY

Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate

(2013) Jennifer L. Leight et al.   BIOMATERIALS

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach

(2013) D. Loessner et al.   Integrative Biology

Vemurafenib Induces Senescence Features in Melanoma Cells

(2013) Sebastian Haferkamp et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines

(2013) A Vultur et al.   ONCOGENE

Small peptide functionalized thiol–ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition

(2012) Sarah T. Gould et al.   Acta Biomaterialia

A Microwell Cell Culture Platform for the Aggregation of Pancreatic β-Cells

(2012) Abigail B. Bernard et al.   TISSUE ENGINEERING PART C-METHODS

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels

(2011) Sarah B. Anderson et al.   BIOMATERIALS

PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

(2011) K. H. T. Paraiso et al.   CANCER RESEARCH

Thiol-Ene Click Chemistry

(2010) Charles E. Hoyle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

(2010) Y. Shao et al.   CANCER RESEARCH

Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia

(2010) Todd W Ridky et al.   NATURE MEDICINE

Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells

(2010) F M Kaplan et al.   ONCOGENE

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

(2010) John T. Lee et al.   Pigment Cell & Melanoma Research

PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells

(2010) Ruth Halaban et al.   Pigment Cell & Melanoma Research

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

(2009) Benjamin D. Fairbanks et al.   ADVANCED MATERIALS

Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility

(2009) Benjamin D. Fairbanks et al.   BIOMATERIALS

The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces

(2009) Kristin M. Hennessy et al.   BIOMATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Absence of Filamin A Prevents Cells from Responding to Stiffness Gradients on Gels Coated with Collagen but not Fibronectin

(2009) Fitzroy J. Byfield et al.   BIOPHYSICAL JOURNAL

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration

(2009) Michael P. Schwartz et al.   Integrative Biology

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

(2009) G M Argast et al.   ONCOGENE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

The hard life of soft cells

(2009) Paul A. Janmey et al.   CELL MOTILITY AND THE CYTOSKELETON

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

(2008) N. K. Haass et al.   CLINICAL CANCER RESEARCH

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

(2008) Britta Weigelt et al.   SEMINARS IN CANCER BIOLOGY