Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition

Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density

(2013) Kyle A. Kyburz et al.   Acta Biomaterialia

Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate

(2013) Jennifer L. Leight et al.   BIOMATERIALS

MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines

(2013) A Vultur et al.   ONCOGENE

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

MMP2 expression is a prognostic marker for primary melanoma patients

(2012) Anand Rotte et al.   CELLULAR ONCOLOGY

β1 integrin is required for anchorage-independent growth and invasion of tumor cells in a context dependent manner

(2011) Allana M. Schooley et al.   CANCER LETTERS

Mechanisms of Resistance to RAF Inhibitors in Melanoma

(2011) Andrew E. Aplin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells

(2010) Ruth Halaban et al.   Pigment Cell & Melanoma Research

A Phase II Trial of Sorafenib in Metastatic Melanoma with Tissue Correlates

(2010) Patrick A. Ott et al.   PLoS One

A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

(2009) Benjamin D. Fairbanks et al.   ADVANCED MATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration

(2009) Michael P. Schwartz et al.   Integrative Biology

A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis

(2009) J S Blackburn et al.   ONCOGENE

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA