Dietary Flavonoids in the Prevention of T2D: An Overview

Adipose tissue macrophages: going off track during obesity

(2016) Lily Boutens et al.   DIABETOLOGIA

Gut microbiota and diet in patients with different glucose tolerance

(2015) L. V. Egshatyan et al.   Endocrine Connections

Effect of IL-6 on the insulin sensitivity in patients with type 2 diabetes

(2014) N. M. Harder-Lauridsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women

(2014) Masaki Takahashi et al.   BRITISH JOURNAL OF NUTRITION

Dietary grape powder increases IL-1ß and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans

(2014) Susan J. Zunino et al.   BRITISH JOURNAL OF NUTRITION

Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes

(2014) Stephanie T. Chung et al.   DIABETOLOGIA

Central Adiponectin Acutely Improves Glucose Tolerance in Male Mice

(2014) Christiane E. Koch et al.   ENDOCRINOLOGY

Four Flavonoid Compounds from Phyllostachys edulis Leaf Extract Retard the Digestion of Starch and Its Working Mechanisms

(2014) Jun-Peng Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

(2014) Pia V. Röder et al.   PLoS One

Genistein Protects Female Nonobese Diabetic Mice from Developing Type 1 Diabetes When Fed a Soy- and Alfalfa-free Diet

(2014) Tai L. Guo et al.   TOXICOLOGIC PATHOLOGY

Tea consumption and risk of type 2 diabetes: a dose–response meta-analysis of cohort studies

(2013) Wan-Shui Yang et al.   BRITISH JOURNAL OF NUTRITION

Dietary flavonoids intake and risk of type 2 diabetes: A meta-analysis of prospective cohort studies

(2013) Yu-Jian Liu et al.   CLINICAL NUTRITION

Role of Reduced  -Cell Mass Versus Impaired  -Cell Function in the Pathogenesis of Type 2 Diabetes

(2013) J. J. Meier et al.   DIABETES CARE

Economic Costs of Diabetes in the U.S. in 2012

(2013)   DIABETES CARE

In vivo and in vitro antioxidant activity and α-glucosidase, α-amylase inhibitory effects of flavonoids from Cichorium glandulosum seeds

(2013) Xincheng Yao et al.   FOOD CHEMISTRY

α-Glucosidase inhibition by luteolin: Kinetics, interaction and molecular docking

(2013) Jiakai Yan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intakes of total and individual flavonoids by US adults

(2013) Wei Bai et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Plant Flavonoids—Biosynthesis, Transport and Involvement in Stress Responses

(2013) Elisa Petrussa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans

(2013) Cecilia Brunetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Helichrysum and Grapefruit Extracts Inhibit Carbohydrate Digestion and Absorption, Improving Postprandial Glucose Levels and Hyperinsulinemia in Rats

(2013) Ana Laura de la Garza et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia

(2013) Rita Basu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations

(2013) Raul Zamora-Ros et al.   JOURNAL OF NUTRITION

Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress

(2013) María Ángeles Martín et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance

(2013) Xiuying Zhang et al.   PLoS One

Regulation of Glucose Transporter Expression in Human Intestinal Caco-2 Cells following Exposure to an Anthocyanin-Rich Berry Extract

(2013) Fawaz Alzaid et al.   PLoS One

Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies

(2013) I. Muraki et al.   BMJ-British Medical Journal

Dietary flavonoid intakes and risk of type 2 diabetes in US men and women

(2012) Nicole M Wedick et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes

(2012) Zhuo Fu et al.   Applied Physiology Nutrition and Metabolism

Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids

(2012) Long Yi et al.   BIOCHIMIE

Role of leptin and adiponectin in insulin resistance

(2012) Amita Yadav et al.   CLINICA CHIMICA ACTA

Updated Knowledge about Polyphenols: Functions, Bioavailability, Metabolism, and Health

(2012) J. M. Landete   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Effect of Eriodictyol on Glucose Uptake and Insulin Resistance in Vitro

(2012) Wei-Yun Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Serviceberry [Amelanchier alnifolia (Nutt.) Nutt. ex. M. Roem (Rosaceae)] leaf extract inhibits mammalian α-glucosidase activity and suppresses postprandial glycemic response in a mouse model of diet-induced obesity and hyperglycemia

(2012) Albert J. Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: A randomized controlled trial

(2012) Y. Zhu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects

(2012) Riitta Törrönen et al.   Journal of Functional Foods

Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function

(2012) Elizabeth. R. Gilbert et al.   Food & Function

The addition of raspberries and blueberries to a starch-based food does not alter the glycaemic response

(2011) Miriam E. Clegg et al.   BRITISH JOURNAL OF NUTRITION

Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes

(2011) Ashok Kumar Sharma et al.   BRITISH JOURNAL OF NUTRITION

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

(2011) Hua V. Lin et al.   Cell Metabolism

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

(2011) Motoharu Awazawa et al.   Cell Metabolism

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

(2011) Dae Hyun Kim et al.   DIABETES

Berry Polyphenols Inhibit α-Amylasein Vitro: Identifying Active Components in Rowanberry and Raspberry

(2011) Dominic Grussu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese–diabetic mice

(2011) Tsuyoshi Goto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin

(2011) Yoshiki Miyata et al.   LIFE SCIENCES

Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract

(2011) Tsuyoshi Goto et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis

(2011) Danielle Fontana Pereira et al.   NUTRITION

Flavonoids as Nutraceuticals: A Review

(2011) AR Tapas et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Antidiabetic Effects of Total Flavonoids from Litsea Coreana leve on Fat-Fed, Streptozotocin-Induced Type 2 Diabetic Rats

(2010) Yun-Xia Lu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

7-O-Methylaromadendrin Stimulates Glucose Uptake and Improves Insulin Resistance in Vitro

(2010) Wei Yun Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice

(2010) Zhuo Fu et al.   BRITISH JOURNAL OF NUTRITION

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy

(2010) R. A. Rizza   DIABETES

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

Impact of Dietary Polyphenols on Carbohydrate Metabolism

(2010) Kati Hanhineva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unanticipated Benefits of CAM Therapies for Back Pain: An Exploration of Patient Experiences

(2010) Clarissa Hsu et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycemic Responses to Sweetened Dried and Raw Cranberries in Humans with Type 2 Diabetes

(2010) Ted Wilson et al.   JOURNAL OF FOOD SCIENCE

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

(2010) Hideaki Kaneto et al.   MEDIATORS OF INFLAMMATION

Antidiabetic effects of fermented soybean products on type 2 diabetes

(2010) Dae Young Kwon et al.   NUTRITION RESEARCH

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Flavonoids and Isoflavonoids: From Plant Biology to Agriculture and Neuroscience

(2010) R. A. Dixon et al.   PLANT PHYSIOLOGY

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects

(2009) Yu Qin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabetes Mellitus

(2009) Rachel Huxley   ARCHIVES OF INTERNAL MEDICINE

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

(2009) Motoharu Awazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genistein-Derivatives from Tetracera scandens Stimulate Glucose-Uptake in L6 Myotubes

(2009) Myung Sun Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake

(2009) Jie Cao et al.   BRITISH JOURNAL OF NUTRITION

Interleukin-6 Attenuates Insulin-Mediated Increases in Endothelial Cell Signaling but Augments Skeletal Muscle Insulin Action via Differential Effects on Tumor Necrosis Factor-  Expression

(2009) D. Y.C. Yuen et al.   DIABETES

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity

(2009) P. Kar et al.   DIABETIC MEDICINE

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function

(2009) Jessica L Fargnoli et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Synergistic Effect of Apple Extracts and Quercetin 3-β-d-Glucoside Combination on Antiproliferative Activity in MCF-7 Human Breast Cancer Cells in Vitro

(2009) Jun Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interaction between Phenolics and Gut Microbiota: Role in Human Health

(2009) María V. Selma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative Evaluation of Quercetin, Isoquercetin and Rutin as Inhibitors of α-Glucosidase

(2009) Yan Qin Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tea Consumption and Risk of Type 2 Diabetes: A Meta-Analysis of Cohort Studies

(2009) Yali Jing et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance☆

(2009) Gemma Montagut et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin

(2009) Gemma Montagut et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men

(2009) Charlotte Brøns et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structural characterization of flavonoid glycosides by multi-stage mass spectrometry

(2009) Viktoria Vukics et al.   MASS SPECTROMETRY REVIEWS

A molecular mathematical model of glucose mobilization and uptake

(2009) Weijiu Liu et al.   MATHEMATICAL BIOSCIENCES

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Physicians and nurses use and recommend dietary supplements: report of a survey

(2009) Annette Dickinson et al.   Nutrition Journal

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition

(2009) Z.F. Zhang et al.   PHYTOMEDICINE

Antioxidant and Protective Effects of Major Flavonoids fromTeucrium poliumonβ-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

(2009) Mohammad Esmaeili et al.   PLANTA MEDICA

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

(2009) V. T. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Tea Intake is Associated with Reduced Prevalence of (Type 2) Diabetes Mellitus among Elderly People from Mediterranean Islands: MEDIS Epidemiological Study

(2009) Demosthenes B. Panagiotakos et al.   YONSEI MEDICAL JOURNAL

Insulin action on glucose transporters through molecular switches, tracks and tethers

(2008) Hilal Zaid et al.   BIOCHEMICAL JOURNAL

Glucokinase and molecular aspects of liver glycogen metabolism

(2008) Loranne Agius   BIOCHEMICAL JOURNAL

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism

(2008) C. A. Witczak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intracellular Lipid Accumulation in Liver and Muscle and the Insulin Resistance Syndrome

(2008) Cristina Lara-Castro et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells

(2008) Chandrasagar B. Dugani et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The regulation of AMP-activated protein kinase by upstream kinases

(2008) D Carling et al.   INTERNATIONAL JOURNAL OF OBESITY

Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human α-Amylase

(2008) Elena Lo Piparo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human Glycemic Response and Phenolic Content of Unsweetened Cranberry Juice

(2008) Ted Wilson et al.   JOURNAL OF MEDICINAL FOOD

Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity

(2008) Xian-Kang Fang et al.   LIFE SCIENCES

Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans

(2008) Michael M. Swarbrick et al.   Metabolic Syndrome and Related Disorders

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes

(2008) Tomonori Nagao et al.   Obesity

β-cell failure as a complication of diabetes

(2008) K. J. Chang-Chen et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS