Apoptosis and non-alcoholic fatty liver diseases

3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways

(2018) Qiong Ou-Yang et al.   ACTA PHARMACOLOGICA SINICA

Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice

(2018) Junli Zhang et al.   LIFE SCIENCES

Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

(2018) Fangfang Huang et al.   Marine Drugs

Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis

(2018) Tingting Shi et al.   PLoS One

Apoptotic Caspases: Multiple or Mistaken Identities?

(2018) Kate McArthur et al.   TRENDS IN CELL BIOLOGY

Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease

(2018) Amir Hajighasem et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Treatment options for nonalcoholic steatohepatitis - a safety evaluation

(2017) Danny Issa et al.   Expert Opinion On Drug Safety

The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance

(2017) Quan-Yu Zhang et al.   HEPATOLOGY

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

(2017) Songtao Li et al.   HEPATOLOGY

Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes

(2017) Carlos R. P. Dechandt et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma

(2017) Noriyuki Koyama et al.   JOURNAL OF GASTROENTEROLOGY

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

(2017) Janin Henkel et al.   MOLECULAR MEDICINE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

(2017) Pedro M Rodrigues et al.   Cell Death & Disease

Hepatoprotective potential of isoquercitrin against type 2 diabetes-induced hepatic injury in rats

(2017) Xiao-Li Huang et al.   Oncotarget

Granulocyte colony stimulating factor treatment in non-alcoholic fatty liver disease: beyond marrow cell mobilization

(2017) Ho Hyun Nam et al.   Oncotarget

Clinical implications of understanding the association between oxidative stress and pediatric NAFLD

(2017) Jake P. Mann et al.   Expert Review of Gastroenterology & Hepatology

Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis

(2017) Xi Jin et al.   PLoS One

Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice

(2017) Siân P. Cartland et al.   Scientific Reports

Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis

(2016) Ruonan Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

C-X-C motif chemokine 10 in non-alcoholic steatohepatitis: role as a pro-inflammatory factor and clinical implication

(2016) Zhilu Xu et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Involvement of senescence marker protein-30 in glucose metabolism disorder and non-alcoholic fatty liver disease

(2016) Yoshitaka Kondo et al.   Geriatrics & Gerontology International

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

(2016) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease

(2016) Konstantin Kazankov et al.   LIVER INTERNATIONAL

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice

(2016) Surim Park et al.   TOXICOLOGY LETTERS

Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis

(2016) J Huo et al.   Cell Death & Disease

Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases

(2016) Nabil Eid et al.   Frontiers in Pharmacology

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts

(2016) Shuang Liang et al.   Frontiers in Physiology

Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis

(2016) Davide Povero et al.   Diabetes & Metabolism Journal

Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

(2015) Xiaoying Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Myeloperoxidase–Hepatocyte–Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

(2015) Benjamin Pulli et al.   ANTIOXIDANTS & REDOX SIGNALING

Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis

(2015) Jessica Seeßle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Circulating Soluble Fas and Fas Ligand Levels Are Elevated in Children with Nonalcoholic Steatohepatitis

(2015) Naim Alkhouri et al.   DIGESTIVE DISEASES AND SCIENCES

Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model

(2015) Mariana Verdelho Machado et al.   DIGESTIVE DISEASES AND SCIENCES

Liver-Specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steatohepatitis and Hepatocellular Carcinoma in Mice

(2015) Chandrashekhar R. Gandhi et al.   GASTROENTEROLOGY

Glucagon-like peptide-1 preserves non-alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress-associated pathway

(2015) Na Ao et al.   HEPATOLOGY RESEARCH

E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis

(2015) Pierre-Damien Denechaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

(2015) Leila Idrissova et al.   JOURNAL OF HEPATOLOGY

Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening

(2015) Xueyao Yin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

(2015) Yasuka Matsunaga et al.   MEDIATORS OF INFLAMMATION

CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis

(2015) Jeffrey A. Willy et al.   MOLECULAR BIOLOGY OF THE CELL

Lipoapoptosis induced by saturated free fatty acids stimulates monocyte migration: a novel role for Pannexin1 in liver cells

(2015) Feng Xiao et al.   Purinergic Signalling

MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells

(2015) Masato Nakamura et al.   PLoS One

Palmitic acid induces autophagy in hepatocytes via JNK2 activation

(2014) Qian-qian Tu et al.   ACTA PHARMACOLOGICA SINICA

The expression and secretion of vimentin in the progression of non-alcoholic steatohepatitis

(2014) Su Jin Lee et al.   BMB Reports

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Roles of Fas/Fasl, Bcl-2/Bax, and Caspase-8 in rat nonalcoholic fatty liver disease pathogenesis

(2014) C.P. Li et al.   GENETICS AND MOLECULAR RESEARCH

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

High-fat diet triggers Mallory-Denk body formation through misfolding and crosslinking of excess keratin 8

(2014) Ozlem Kucukoglu et al.   HEPATOLOGY

ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease

(2014) Fang Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HIF-1α Expression as a Protective Strategy of HepG2 Cells Against Fatty Acid-Induced Toxicity

(2014) Wonbaek Yoo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice

(2014) Daniela C. Kroy et al.   JOURNAL OF HEPATOLOGY

Mmu-miR-615-3p Regulates Lipoapoptosis by Inhibiting C/EBP Homologous Protein

(2014) Yasuhiro Miyamoto et al.   PLoS One

Autophagy protects against palmitate-induced apoptosis in hepatocytes

(2014) Ning Cai et al.   Cell and Bioscience

Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

(2014) Kathryn H. Williams et al.   Journal of Diabetes

Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy

(2014) Jiaxin Lou et al.   Biomed Research International

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Apoptotic and anti-apoptotic seromarkers for assessment of disease severity of non-alcoholic steatohepatitis

(2014) Hanan El Bassat et al.   Arab Journal of Gastroenterology

Degradation of cIAPs contributes to hepatocyte lipoapoptosis

(2013) Yuko Akazawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis

(2013) Han-Ning Wang et al.   APMIS

Cyclooxygenase-2 Promotes Hepatocellular Apoptosis by Interacting with TNF-α and IL-6 in the Pathogenesis of Nonalcoholic Steatohepatitis in Rats

(2013) Qi Cheng et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

(2013) Ling Yang et al.   HEPATOLOGY

Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease

(2013) Bryan D. Maliken et al.   HEPATOLOGY

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis

(2013) Erika Segear Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Levels of FGF-21 in Obese Youth: Associations With Liver Fat Content and Markers of Liver Damage

(2013) Cosimo Giannini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency

(2013) Kan Toriguchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice

(2013) Yu-Gang Wang et al.   Journal of the Chinese Medical Association

Molecular signature of adipose tissue in patients with both Non-Alcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovarian Syndrome (PCOS)

(2013) Ancha Baranova et al.   Journal of Translational Medicine

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

(2013) Samar H. Ibrahim et al.   LIVER INTERNATIONAL

The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease

(2012) Erin K. Daugherity et al.   CELL CYCLE

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

Hepatic progenitor cells activation, fibrosis, and adipokines production in pediatric nonalcoholic fatty liver disease

(2012) Valerio Nobili et al.   HEPATOLOGY

Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model*

(2012) Marcela Aparicio-Vergara et al.   HEPATOLOGY

p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

(2012) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes

(2012) Keisuke Kakisaka et al.   JOURNAL OF HEPATOLOGY

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

New insights into the functions and localization of nuclear transglutaminase 2

(2011) Ting-Fang Kuo et al.   FEBS Journal

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

(2011) Ting-Fang Kuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA

(2011) Sophie C. Cazanave et al.   JOURNAL OF LIPID RESEARCH

Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications

(2011) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Tumor necrosis factor-α accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease

(2010) Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-Alcoholic Steatohepatitis Pathogenesis: Role of Repair in Regulating the Disease Progression

(2010) Youngmi Jung et al.   DIGESTIVE DISEASES

Role of Scavenger Receptor A and CD36 in Diet-Induced Nonalcoholic Steatohepatitis in Hyperlipidemic Mice

(2010) Veerle Bieghs et al.   GASTROENTEROLOGY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

(2010) Huating Li et al.   JOURNAL OF HEPATOLOGY

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

(2010) Samar H. Ibrahim et al.   JOURNAL OF HEPATOLOGY

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C

(2010) Carmelo García-Monzón et al.   JOURNAL OF HEPATOLOGY

Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

(2009) Hella Wobser et al.   CELL RESEARCH

Major histocompatibility complex class I-related chains A and B (MIC A/B): A novel role in nonalcoholic steatohepatitis

(2009) Alisan Kahraman et al.   HEPATOLOGY

Activation of the complement system in human nonalcoholic fatty liver disease

(2009) Sander S. Rensen et al.   HEPATOLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study

(2009) Ariel E. Feldstein et al.   HEPATOLOGY

Lipopolysaccharide triggered TNF-α-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model

(2009) Hiroshi Kudo et al.   JOURNAL OF HEPATOLOGY