Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model*

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

(2012) Veerle Bieghs et al.   PLoS One

Tumor Necrosis Factor-α Converting Enzyme Inactivation Ameliorates High-Fat Diet-Induced Insulin Resistance and Altered Energy Homeostasis

(2011) Hidehiro Kaneko et al.   CIRCULATION JOURNAL

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

(2011) Núria Tarrats et al.   HEPATOLOGY

Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels

(2011) David J. Rowlands et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary cholesterol, female gender and n-3 fatty acid deficiency are more important factors in the development of non-alcoholic fatty liver disease than the saturation index of the fat

(2011) Tine M Comhair et al.   Nutrition & Metabolism

Tumor Necrosis Factor α-Converting Enzyme Inhibition Reverses Hepatic Steatosis and Improves Insulin Sensitivity Markers and Surgical Outcome in Mice

(2011) Vincent E. de Meijer et al.   PLoS One

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Deletion of tumor necrosis factor-α receptor type 1 exacerbates insulin resistance and hepatic steatosis in aromatase knockout mice

(2010) Katsumi Toda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

TNF-α, a potent lipid metabolism regulator

(2009) Xiuping Chen et al.   CELL BIOCHEMISTRY AND FUNCTION

Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

(2009) A. Monroy et al.   DIABETOLOGIA

Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

(2009) Nathalie Pamir et al.   ENDOCRINOLOGY

Increased tumor necrosis factor α-converting enzyme activity induces insulin resistance and hepatosteatosis in mice

(2009) Loredana Fiorentino et al.   HEPATOLOGY

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes

(2008) Anna Ludovica Fracanzani et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM