HIF-1α Expression as a Protective Strategy of HepG2 Cells Against Fatty Acid-Induced Toxicity

Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells

(2013) Fanzhi Kong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Increased Selenoprotein P Levels in Subjects with Visceral Obesity and Nonalcoholic Fatty Liver Disease

(2013) Hae Yoon Choi et al.   Diabetes & Metabolism Journal

Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease

(2012) Michael J. Pagliassotti   Annual Review of Nutrition

Oxidative stress impairs HIF1α activation: a novel mechanism for increased vulnerability of steatotic hepatocytes to hypoxic stress

(2012) Sarit Anavi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia

(2011) Qing He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Positive Cross-Talk Between Hypoxia Inducible Factor-1α and Liver X Receptor α Induces Formation of Triglyceride-Loaded Foam Cells

(2011) Tae-Young Na et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication

(2011) Mark A. Creager et al.   CIRCULATION

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

(2011) Bharath Nath et al.   HEPATOLOGY

Functional regulation of HIF-1α under normoxia-is there more than post-translational regulation?

(2011) A. Kuschel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

(2011) Xinguo Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

(2011) Yasumasa Nishiyama et al.   JOURNAL OF HEPATOLOGY

Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo

(2011) Gabor Czibik et al.   LIFE SCIENCES

Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes

(2011) Yong Zhang et al.   Lipids in Health and Disease

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

(2010) Sophie C. Cazanave et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms and clinical implications of hepatocyte lipoapoptosis

(2010) Sophie C Cazanave et al.   Clinical Lipidology

High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia

(2010) Julieta Carabelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

(2010) Samar H. Ibrahim et al.   JOURNAL OF HEPATOLOGY

Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells

(2010) Xuemei Gu et al.   LIFE SCIENCES

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Hypoxia inducible factor-1α accumulation in steatotic liver preservation: Role of nitric oxide

(2010) Mohamed Amine Zaouali   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2

(2009) Xuerui Yang et al.   CELL RESEARCH

Factors Interacting with HIF-1α mRNA: Novel Therapeutic Targets

(2009) Stefanie Galban et al.   CURRENT PHARMACEUTICAL DESIGN

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

(2009) Hayato Hikita et al.   HEPATOLOGY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines

(2008) Swapan K. Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of hypoxia-inducible factor in cell survival during myocardial ischemia–reperfusion

(2008) G Loor et al.   CELL DEATH AND DIFFERENTIATION

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

Steatosis Reversibly Increases Hepatocyte Sensitivity to Hypoxia-Reoxygenation Injury

(2008) François Berthiaume et al.   JOURNAL OF SURGICAL RESEARCH