A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes

(2017) Daniela Poli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms

(2017) Jesse Lea Carlin et al.   NEUROPHARMACOLOGY

Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists

(2016) David Rodríguez et al.   ACS Chemical Biology

Structural refinement of pyrazolo[4,3- d ]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A 3 adenosine receptor

(2016) Lucia Squarcialupi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists

(2016) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

A3 adenosine receptor agonist, CF102, protects against hepatic ischemia/reperfusion injury following partial hepatectomy

(2016) Gil Ohana et al.   Molecular Medicine Reports

Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

(2016) Patrycja Koszałka et al.   PLoS One

Adenosine arrests breast cancer cell motility by A3 receptor stimulation

(2016) Carola Ledderose et al.   Purinergic Signalling

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells

(2016) Angelo Torres et al.   Oncotarget

Metabolic mapping of A3 adenosine receptor agonist MRS5980

(2015) Zhong-Ze Fang et al.   BIOCHEMICAL PHARMACOLOGY

Understanding allosteric interactions in G protein-coupled receptors using Supervised Molecular Dynamics: A prototype study analysing the human A3 adenosine receptor positive allosteric modulator LUF6000

(2015) Giuseppe Deganutti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hide and seek: a comparative autoradiographic in vitro investigation of the adenosine A3 receptor

(2015) D. Haeusler et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Pyrazin-2(1H)-ones as a novel class of selective A3 adenosine receptor antagonists

(2015) Jhonny Azuaje et al.   Future Medicinal Chemistry

5′-C-Ethyl-tetrazolyl-N6-Substituted Adenosine and 2-Chloro-adenosine Derivatives as Highly Potent Dual Acting A1 Adenosine Receptor Agonists and A3 Adenosine Receptor Antagonists

(2015) Riccardo Petrelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Reaction To Obtain N,N′-Disubstituted Guanidines of Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine Scaffold as Human A3 Adenosine Receptor Antagonists

(2015) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Down-regulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling

(2015) Noam Rudich et al.   MOLECULAR IMMUNOLOGY

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist

(2015) Leigh A. Stoddart et al.   NEUROPHARMACOLOGY

Expression of adenosine receptor subclasses in malignant and adjacent normal human prostate tissues

(2015) Samira Mousavi et al.   PROSTATE

Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells

(2015) Iolanda D’Alimonte et al.   Purinergic Signalling

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

(2015) Mohamad Wessam Alnouri et al.   Purinergic Signalling

Anticancer effect of adenosine on gastric cancerviadiverse signaling pathways

(2015) Ayako Tsuchiya   WORLD JOURNAL OF GASTROENTEROLOGY

Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

(2015) Dilip K. Tosh et al.   MedChemComm

A2B and A3 Adenosine Receptors Modulate Vascular Endothelial Growth Factor and Interleukin-8 Expression in Human Melanoma Cells Treated with Etoposide and Doxorubicin

(2015) Stefania Merighi et al.   NEOPLASIA

Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity

(2015) Sarvesh Jajoo et al.   NEOPLASIA

Effect of a toggle switch mutation in TM6 of the human adenosine A3receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

(2014) Leigh A Stoddart et al.   BRITISH JOURNAL OF PHARMACOLOGY

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma

(2014) Ana S. Soares et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Adenosine and inflammation: what's new on the horizon?

(2014) Luca Antonioli et al.   DRUG DISCOVERY TODAY

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

(2014) Akshata Nayak et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A3 Adenosine Receptor Agonists

(2014) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

A3Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect:In VivoStudies and Molecular Mechanism of Action

(2014) Shira Cohen et al.   MEDIATORS OF INFLAMMATION

The role of activated adenosine receptors in degranulation of human LAD2 mast cells

(2014) Chi Ting Leung et al.   Purinergic Signalling

Adenosine A3 Receptor Activation Attenuates Lung Ischemia-Reperfusion Injury

(2013) Daniel P. Mulloy et al.   ANNALS OF THORACIC SURGERY

Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines

(2013) Monika Sakowicz-Burkiewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, suppresses angiogenesis by regulating PI3K/AKT/mTOR and ERK signaling in endothelial cells

(2013) Gi Dae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization by flow cytometry of fluorescent, selective agonist probes of the A3 adenosine receptor

(2013) Eszter Kozma et al.   BIOCHEMICAL PHARMACOLOGY

Apoptosis-Related Gene Transcription in Human A549 Lung Cancer Cells via A3Adenosine Receptor

(2013) Hitomi Kamiya et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

(2013) Ross Corriden et al.   EMBO REPORTS

Rational Design of Sulfonated A3 Adenosine Receptor-Selective Nucleosides as Pharmacological Tools To Study Chronic Neuropathic Pain

(2013) Silvia Paoletta et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3 Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation

(2013) Lucia Squarcialupi et al.   JOURNAL OF MEDICINAL CHEMISTRY

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study

(2013) S. M. Stemmer et al.   ONCOLOGIST

A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes

(2013) Stefania Gessi et al.   PHARMACOLOGICAL RESEARCH

Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A2A and A3 Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts

(2013) Fabrizio Vincenzi et al.   PLoS One

Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome

(2013) Nicholas G Campbell et al.   Molecular Autism

Regulation of Inflammation by Adenosine

(2013) György Haskó et al.   Frontiers in Immunology

A3Adenosine Receptor Mediates Apoptosis in 5637 Human Bladder Cancer Cells by GqProtein/PKC-Dependent AIF Upregulation

(2012) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A3Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells

(2012) Tai-ichiro Otsuki et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

AMP Converted from Intracellularly Transported Adenosine Upregulates p53 Expression to Induce Malignant Pleural Mesothelioma Cell Apoptosis

(2012) Yoshitaka Nogi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model

(2012) Katia Varani et al.   EUROPEAN JOURNAL OF CANCER

Impairment of adenosine A3 receptor activity disrupts neutrophil migratory capacity and impacts innate immune function in vivo

(2012) Matt Butler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants

(2012) Lea Madi et al.   EXPERIMENTAL DERMATOLOGY

Controlling murine and rat chronic pain through A3 adenosine receptor activation

(2012) Zhoumou Chen et al.   FASEB JOURNAL

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

(2012) Yang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists

(2012) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications

(2012) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

(2012) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration

(2012) Keiko Ohsawa et al.   JOURNAL OF NEUROCHEMISTRY

A3 Adenosine Receptor Mediates Apoptosis in In Vitro RCC4-VHL Human Renal Cancer Cells by Up-Regulating AMID Expression

(2012) Hisao Nagaya et al.   JOURNAL OF UROLOGY

The Adenosine A3 Receptor Agonist Cl-IB-MECA Induces Cell Death Through Ca2+/ROS-Dependent Down Regulation of ERK and Akt in A172 Human Glioma Cells

(2012) Thae Hyun Kim et al.   NEUROCHEMICAL RESEARCH

The Anti-Tumor Effect of A3 Adenosine Receptors Is Potentiated by Pulsed Electromagnetic Fields in Cultured Neural Cancer Cells

(2012) Fabrizio Vincenzi et al.   PLoS One

Adoptive Immunotherapy with Cl-IB-MECA-Treated CD8+ T Cells Reduces Melanoma Growth in Mice

(2012) Antonella Montinaro et al.   PLoS One

Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?

(2012) V. Kumar   Purinergic Signalling

Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action

(2012) Lisa K Stamp et al.   ARTHRITIS RESEARCH & THERAPY

Truncated Nucleosides as A3 Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

(2012) Dilip K. Tosh et al.   ACS Medicinal Chemistry Letters

Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

(2011) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS

(2011) Giovanni Forte et al.   CYTOKINE

A Nonsynonymous Variant I248L of the Adenosine A3 Receptor Is Associated with Coronary Heart Disease in a Latvian Population

(2011) Raitis Peculis et al.   DNA AND CELL BIOLOGY

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Investigational A3adenosine receptor targeting agents

(2011) Balázs Koscsó et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine receptor targeting in health and disease

(2011) Stefania Gessi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

(2011) Lauren T. May et al.   FASEB JOURNAL

Suppression of inflammation response by a novel A3 adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-κB signaling

(2011) Hak-Sun Lee et al.   IMMUNOBIOLOGY

Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway

(2011) Mahmoud Aghaei et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Disparity in FcεRI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine

(2011) Gregorio Gomez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A3Adenosine Receptor Antagonists

(2011) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands

(2011) Xiyan Hou et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Identification of the 2-Phenylphthalazin-1(2H)-one Scaffold as a New Decorable Core Skeleton for the Design of Potent and Selective Human A3Adenosine Receptor Antagonists

(2011) Daniela Poli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of plaque-type psoriasis with oral CF101: data from an exploratory randomized phase 2 clinical trial

(2011) M. David et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

(2011) Katia Varani et al.   ARTHRITIS RESEARCH & THERAPY

A3Receptors Are Overexpressed in Pleura from Patients with Mesothelioma and Reduce Cell Growth via Akt/Nuclear Factor-κB Pathway

(2010) Katia Varani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors

(2010) Stefania Gessi et al.   BIOCHEMICAL PHARMACOLOGY

Adenosine receptors and cancer

(2010) Stefania Gessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional variability of the adenosine A3 receptor (ADORA3) gene polymorphism in aspirin-induced urticaria

(2010) S.-H. Kim et al.   BRITISH JOURNAL OF DERMATOLOGY

Control of enteric neuromuscular functions by purinergic A3 receptors in normal rat distal colon and experimental bowel inflammation

(2010) L Antonioli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes

(2010) K Varani et al.   BRITISH JOURNAL OF PHARMACOLOGY

A3 Receptor Ligands: Past, Present and Future Trends

(2010) S. Taliani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

(2010) S. Cohen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NovelN2-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A3Receptor Antagonists: Inhibition of A3-Mediated Human Glioblastoma Cell Proliferation†

(2010) Sabrina Taliani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrimidine Derivatives as Potent and Selective A3Adenosine Receptor Antagonists

(2010) Vicente Yaziji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine Modulates HIF-1α, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells

(2009) Stefania Gessi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment

(2009) S. Bar-Yehuda et al.   ARTHRITIS AND RHEUMATISM

Normalization of A2Aand A3adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor α but not methotrexate

(2009) Katia Varani et al.   ARTHRITIS AND RHEUMATISM

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

Nucleoside Transporter Proteins

(2009) Miriam Molina-Arcas et al.   Current Vascular Pharmacology

A2A adenosine receptor overexpression and functionality, as well as TNF-α levels, correlate with motor symptoms in Parkinson’s disease

(2009) Katia Varani et al.   FASEB JOURNAL

Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells

(2009) Silvana Morello et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Divergent Solution-Phase Synthesis of Diarylpyrimidine Libraries as Selective A3Adenosine Receptor Antagonists

(2009) Vicente Yaziji et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Adenosine Blocks IFN- -Induced Phosphorylation of STAT1 on Serine 727 to Reduce Macrophage Activation

(2009) K. E. Barnholt et al.   JOURNAL OF IMMUNOLOGY

Novel 2- and 4-Substituted 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as Allosteric Modulators of the A3Adenosine Receptor

(2009) Yoonkyung Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of 2-Alkynyl-N6-methyl-5′-N-methylcarboxamidoadenosine Derivatives as Potent and Highly Selective Agonists for the Human Adenosine A3Receptor‡

(2009) Rosaria Volpini et al.   JOURNAL OF MEDICINAL CHEMISTRY

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold To Obtain Potent and Selective Human A3Adenosine Receptor Antagonists: New Insights into the Receptor−Antagonist Recognition†

(2009) Ombretta Lenzi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of 2,4-Disubstituted Quinolines as a New Class of Allosteric Enhancers of the Adenosine A3Receptor

(2009) Laura H. Heitman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functionalized Congeners of A3Adenosine Receptor-Selective Nucleosides Containing a Bicyclo[3.1.0]hexane Ring System†

(2009) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography

(2009) Dale O. Kiesewetter et al.   NUCLEAR MEDICINE AND BIOLOGY

Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000

(2009) Zhan-Guo Gao et al.   BMC Pharmacology & Toxicology

A3Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis

(2008) Eva Morschl et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The A 3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-κB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats

(2008) A. Ochaion et al.   BIOCHEMICAL PHARMACOLOGY

Structure–activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A3 adenosine receptor antagonists

(2008) Pier Giovanni Baraldi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective A3 adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system

(2008) Artem Melman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists

(2008) Lak Shin Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages

(2008) Emilie Velot et al.   CARDIOVASCULAR RESEARCH

Adenosine Receptor Antagonists:  Translating Medicinal Chemistry and Pharmacology into Clinical Utility

(2008) Pier Giovanni Baraldi et al.   CHEMICAL REVIEWS

Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells

(2008) Xiaoyang Hua et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3Adenosine Receptor Antagonists

(2008) Barbara Cosimelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of the A3 Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils

(2008) D. van der Hoeven et al.   MOLECULAR PHARMACOLOGY

Synthesis and pharmacological characterization of [125I]MRS1898, a high-affinity, selective radioligand for the rat A3 adenosine receptor

(2008) Zhan-Guo Gao et al.   Purinergic Signalling

Thermodynamics of A2B adenosine receptor binding discriminates agonistic from antagonistic behaviour

(2007) Stefania Gessi et al.   BIOCHEMICAL PHARMACOLOGY

Selective Human Adenosine A3 Antagonists based on Pyrido[2,1-f]purine-2,4-diones: Novel Features of hA3 Antagonist Binding

(2007) Eva-María Priego et al.   ChemMedChem

Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields

(2007) K. Varani et al.   OSTEOARTHRITIS AND CARTILAGE

The A3 adenosine receptor: An enigmatic player in cell biology

(2007) Stefania Gessi et al.   PHARMACOLOGY & THERAPEUTICS