G-Protein-Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System

l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies

(2014) Annalisa Pinna et al.   EXPERIMENTAL NEUROLOGY

Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes

(2013) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

Adenosine A2A–cannabinoid CB1 receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission

(2012) Maria Teresa Tebano et al.   BRAIN RESEARCH

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

(2012) José L. Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Istradefylline, an adenosine A2A receptor antagonist, for patients with Parkinson's Disease: A meta-analysis

(2012) Wanqiang Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Endocannabinoid system and mood disorders: Priming a target for new therapies

(2012) Vincenzo Micale et al.   PHARMACOLOGY & THERAPEUTICS

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Istradefylline for the treatment of Parkinson's disease

(2011) Ariane Park et al.   EXPERT OPINION ON PHARMACOTHERAPY

History and Biological Significance of GPCR Heteromerization in the Neuroendocrine System

(2011) Kenjiro Tadagaki et al.   NEUROENDOCRINOLOGY

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors

(2011) Laura Albizu et al.   NEUROPHARMACOLOGY

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

(2011) José L. Moreno et al.   NEUROSCIENCE LETTERS

Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists

(2011) Marco Orru et al.   PLoS One

Past, Present, and Future of the Pathophysiological Model of the Basal Ganglia

(2011) José A. Obeso et al.   Frontiers in Neuroanatomy

Adenosine-cannabinoid receptor interactions. Implications for striatal function

(2010) Sergi Ferré et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dopamine Receptor Homooligomers and Heterooligomers in Schizophrenia

(2010) Melissa L. Perreault et al.   CNS Neuroscience & Therapeutics

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission

(2010) Alberto Martire et al.   JOURNAL OF NEUROCHEMISTRY

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis

(2010) José L Lanciego et al.   JOURNAL OF PSYCHOPHARMACOLOGY

On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers

(2010) Luigi F. Agnati et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Physiology and Pharmacology of Striatal Neurons

(2009) Anatol C. Kreitzer   Annual Review of Neuroscience

Oligomerization of G-protein-coupled receptors: A reality

(2009) Sergi Ferré et al.   CURRENT OPINION IN PHARMACOLOGY

Adenosine A2Areceptors enable the synaptic effects of cannabinoid CB1receptors in the rodent striatum

(2009) Maria Teresa Tebano et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells

(2009) Nuria Cabello et al.   JOURNAL OF NEUROCHEMISTRY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel pharmacological targets based on receptor heteromers

(2008) Rafael Franco et al.   BRAIN RESEARCH REVIEWS

Cannabinoid Receptors: Where They are and What They do

(2008) K. Mackie   JOURNAL OF NEUROENDOCRINOLOGY

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS

Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus

(2008) Alicia Brusco et al.   SYNAPSE

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2AG-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

(2008) Gemma Navarro et al.   TheScientificWorldJOURNAL