Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

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Generic GPCR residue numbers – aligning topology maps while minding the gaps

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Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

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A new mechanism of allostery in a G protein–coupled receptor dimer

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GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

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Single-molecule imaging revealed dynamic GPCR dimerization

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Molecular signatures of G-protein-coupled receptors

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Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

Membrane Driven Spatial Organization of GPCRs

(2013) Sayan Mondal et al.   Scientific Reports

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

(2012) Stefanie Blättermann et al.   Nature Chemical Biology

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

(2012) D. Calebiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland

(2012) Sergio González et al.   PLOS BIOLOGY

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

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Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging

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Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

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Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists

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Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

(2010) J. A. Hern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS