Identification of A3adenosine receptor agonists as novel non-narcotic analgesics

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

(2015) Kali Janes et al.   BRAIN BEHAVIOR AND IMMUNITY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hide and seek: a comparative autoradiographic in vitro investigation of the adenosine A3 receptor

(2015) D. Haeusler et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Engagement of the GABA to KCC2 Signaling Pathway Contributes to the Analgesic Effects of A3AR Agonists in Neuropathic Pain

(2015) Amanda Ford et al.   JOURNAL OF NEUROSCIENCE

An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat

(2015) Ken-ichi Otsuguro et al.   NEUROPHARMACOLOGY

Central or peripheral delivery of an adenosine A1 receptor agonist improves mechanical allodynia in a mouse model of painful diabetic neuropathy

(2015) N.K. Katz et al.   NEUROSCIENCE

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease

(2015) Álvaro Sebastián-Serrano et al.   Computational and Structural Biotechnology Journal

Adenosine A3 Receptor Suppresses Prostate Cancer Metastasis by Inhibiting NADPH Oxidase Activity

(2015) Sarvesh Jajoo et al.   NEOPLASIA

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

(2014) Joshua W. Little et al.   BRAIN

The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1

(2014) Kali Janes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A3 Adenosine Receptor Agonists

(2014) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2014) Yan Li et al.   JOURNAL OF PAIN

TRR469, a potent A1 adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice

(2014) Fabrizio Vincenzi et al.   NEUROPHARMACOLOGY

BDNF: No gain without pain?

(2014) Peter A. Smith   NEUROSCIENCE

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways

(2014) Kali Janes et al.   PAIN

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

(2014) Xiaoming Hu et al.   PROGRESS IN NEUROBIOLOGY

Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and interactions with monocytes during atherosclerosis

(2013) M. Grandoch et al.   BASIC RESEARCH IN CARDIOLOGY

Rational Design of Sulfonated A3 Adenosine Receptor-Selective Nucleosides as Pharmacological Tools To Study Chronic Neuropathic Pain

(2013) Silvia Paoletta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

(2013) Kali Janes et al.   PAIN

Adenosine: setting the stage for plasticity

(2013) Raquel B. Dias et al.   TRENDS IN NEUROSCIENCES

Microglia Control Neuronal Network Excitability via BDNF Signalling

(2013) Francesco Ferrini et al.   NEURAL PLASTICITY

Ectonucleotidases and Nucleotide/Nucleoside Transporters as Pharmacological Targets for Neurological Disorders

(2012) Carla D. Bonan   CNS & Neurological Disorders-Drug Targets

The stimulation of A3 adenosine receptors reduces bone-residing breast cancer in a rat preclinical model

(2012) Katia Varani et al.   EUROPEAN JOURNAL OF CANCER

Controlling murine and rat chronic pain through A3 adenosine receptor activation

(2012) Zhoumou Chen et al.   FASEB JOURNAL

Nucleoside transporters: biological insights and therapeutic applications

(2012) Jung-Suk Choi et al.   Future Medicinal Chemistry

Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

(2012) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine A3 receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes

(2012) A.V. Hinze et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain

(2012) T. Doyle et al.   JOURNAL OF NEUROSCIENCE

Different analgesic effects of adenosine between postoperative and neuropathic pain

(2012) Gotaro Yamaoka et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Alleviating Suffering 101 — Pain Relief in the United States

(2012) Philip A. Pizzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

(2012) Hanns Ulrich Zeilhofer et al.   PHYSIOLOGICAL REVIEWS

A3 Adenosine Receptor Agonist Reduces Brain Ischemic Injury and Inhibits Inflammatory Cell Migration in Rats

(2011) In-Young Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Functionally biased modulation of A3 adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

(2011) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

Pharmacological and therapeutic effects of A3 adenosine receptor agonists

(2011) Pnina Fishman et al.   DRUG DISCOVERY TODAY

Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats

(2011) Young S. Gwak et al.   EXPERIMENTAL NEUROLOGY

Emerging adenosine receptor agonists – an update

(2011) Zhan-Guo Gao et al.   EXPERT OPINION ON EMERGING DRUGS

Retooling Manganese(III) Porphyrin-Based Peroxynitrite Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic Pain

(2011) Smita Rausaria et al.   JOURNAL OF MEDICINAL CHEMISTRY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Pain-relieving prospects for adenosine receptors and ectonucleotidases

(2011) Mark J. Zylka   TRENDS IN MOLECULAR MEDICINE

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

(2011) Katia Varani et al.   ARTHRITIS RESEARCH & THERAPY

Adenosine-induced activation of esophageal nociceptors

(2010) F. Ru et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The resurgence of A2B adenosine receptor signaling

(2010) Carol M. Aherne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats

(2010) Qing-Juan Gong et al.   BRAIN RESEARCH

Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes

(2010) K Varani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric Enhancers of A1 Adenosine Receptors: State of the Art and New Horizons for Drug Development

(2010) R. Romagnoli et al.   CURRENT MEDICINAL CHEMISTRY

Intracerebroventricular injection of an agonist-like monoclonal antibody to adenosine A2A receptor has antinociceptive effects in mice

(2010) Youlet By et al.   JOURNAL OF NEUROIMMUNOLOGY

Prostatic Acid Phosphatase Reduces Thermal Sensitivity and Chronic Pain Sensitization by Depleting Phosphatidylinositol 4,5-Bisphosphate

(2010) N. A. Sowa et al.   JOURNAL OF NEUROSCIENCE

Is BDNF Sufficient for Information Transfer between Microglia and Dorsal Horn Neurons during the Onset of Central Sensitization?

(2010) James E Biggs et al.   Molecular Pain

Adenosine signaling and function in glial cells

(2009) D Boison et al.   CELL DEATH AND DIFFERENTIATION

The anti-inflammatory target A3 adenosine receptor is over-expressed in rheumatoid arthritis, psoriasis and Crohn’s disease

(2009) A. Ochaion et al.   CELLULAR IMMUNOLOGY

N6-Cycloalkyl- andN6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A1Adenosine Receptor with Antinociceptive Effects in Mice

(2009) Palmarisa Franchetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain

(2009) L. C. Loram et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management

(2009) Daniela Salvemini et al.   LIFE SCIENCES

The A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cells

(2009) Mei Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phase 2, Double-blind, Placebo-controlled, Dose-Response Trial of Intravenous Adenosine for Perioperative Analgesia

(2008) Ashraf S. Habib et al.   ANESTHESIOLOGY

Design of (N)-methanocarba adenosine 5′-uronamides as species-independent A3 receptor-selective agonists

(2008) Artem Melman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity

(2008) Michael M. Ndengele et al.   FASEB JOURNAL

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

(2008) Dominik Feuerbach et al.   NEUROPHARMACOLOGY

Spinal glial activation contributes to pathological pain states

(2008) Hong Cao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synthesis and pharmacological characterization of [125I]MRS1898, a high-affinity, selective radioligand for the rat A3 adenosine receptor

(2008) Zhan-Guo Gao et al.   Purinergic Signalling

Different cellular sources and different roles of adenosine: A1 receptor-mediated inhibition through astrocytic-driven volume transmission and synapse-restricted A2A receptor-mediated facilitation of plasticity

(2007) Rodrigo A. Cunha   NEUROCHEMISTRY INTERNATIONAL

Adenosine in the central nervous system: release mechanisms and extracellular concentrations

(2003) Serena Latini et al.   JOURNAL OF NEUROCHEMISTRY