CD73–adenosine: a next-generation target in immuno-oncology

Activation of A2b adenosine receptor regulates ovarian cancer cell growth: involvement of Bax/Bcl-2 and caspase-3

(2015) Sima Hajiahmadi et al.   Biochemistry and Cell Biology

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice

(2015) J. L.-Y. Huang et al.   CANCER RESEARCH

CD73 Is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

(2015) Martin Turcotte et al.   CANCER RESEARCH

CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

(2015) Marian S. Wettstein et al.   DISEASE MARKERS

Safety and Antitumor Activity of Anti–PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer

(2015) Junzo Hamanishi et al.   JOURNAL OF CLINICAL ONCOLOGY

α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) Inhibitors

(2015) Sanjay Bhattarai et al.   JOURNAL OF MEDICINAL CHEMISTRY

p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death

(2015) J S Long et al.   ONCOGENE

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of adenosine receptor subclasses in malignant and adjacent normal human prostate tissues

(2015) Samira Mousavi et al.   PROSTATE

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma

(2015) Bin Zhang et al.   TUMOR BIOLOGY

Host A2B Adenosine Receptors Promote Carcinoma Growth

(2015) Sergey Ryzhov et al.   NEOPLASIA

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

Autophagy in non-small cell lung carcinogenesis

(2014) Shuan Rao et al.   Autophagy

Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

(2014) Sandra Burghoff et al.   BMC CANCER

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors

(2014) S. Chatterjee et al.   CANCER RESEARCH

Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor

(2014) D. Mittal et al.   CANCER RESEARCH

Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients withNT5Emutations

(2014) Qiaoli Li et al.   CELL CYCLE

Early Prediction of Persistent Organ Failure by Soluble CD73 in Patients With Acute Pancreatitis*

(2014) Mikael Maksimow et al.   CRITICAL CARE MEDICINE

Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

(2014) Bertrand Allard et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor

(2014) Tian-zhu Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Adenosine A2B receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells

(2014) Wakako Kaji et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1/CD39) as a new prognostic marker in chronic lymphocytic leukemia

(2014) Nashwa Khairat Abousamra et al.   LEUKEMIA & LYMPHOMA

Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms

(2014) S. S. Virtanen et al.   MOLECULAR CANCER RESEARCH

A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability

(2014) Do-Geun Kim et al.   MOLECULAR NEUROBIOLOGY

Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis

(2014) J Z Zhou et al.   ONCOGENE

NT5E Mutations That Cause Human Disease Are Associated with Intracellular Mistrafficking of NT5E Protein

(2014) Michel Fausther et al.   PLoS One

Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy

(2014) S Daniele et al.   Cell Death & Disease

Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

(2014) M. V. Sitkovsky et al.   Cancer Immunology Research

A new, sensitive ecto-5′-nucleotidase assay for compound screening

(2013) Marianne Freundlieb et al.   ANALYTICAL BIOCHEMISTRY

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

(2013) Melanie Mediavilla-Varela et al.   CANCER BIOLOGY & THERAPY

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

NT5E and FcGBP as key regulators of TGF-1-induced epithelial–mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer

(2013) Li Xiong et al.   CELL AND TISSUE RESEARCH

Ecto-5′-nucleotidase (CD73) promotes tumor angiogenesis

(2013) Li Wang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

(2013) Chindu Govindaraj et al.   CLINICAL IMMUNOLOGY

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Identification of sulfonic acids as efficient ecto-5′-nucleotidase inhibitors

(2013) Jamshed Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Anti-CD73 therapy impairs tumor angiogenesis

(2013) Bertrand Allard et al.   INTERNATIONAL JOURNAL OF CANCER

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targets in triple negative breast cancer

(2013) Sandra A O'Toole et al.   JOURNAL OF CLINICAL PATHOLOGY

Extracellular adenosine regulates naive T cell development and peripheral maintenance

(2013) Caglar Cekic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Prognostic markers and their clinical applicability in chronic lymphocytic leukemia: where do we stand?

(2013) Richard Rosenquist et al.   LEUKEMIA & LYMPHOMA

Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type

(2013) Steven Rust et al.   Molecular Cancer

Extracellular Adenosine Sensing—A Metabolic Cell Death Priming Mechanism Downstream of p53

(2013) Jaclyn S. Long et al.   MOLECULAR CELL

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

Overexpression of CD73 in Prostate Cancer is Associated with Lymph Node Metastasis

(2013) Qing Yang et al.   PATHOLOGY & ONCOLOGY RESEARCH

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

(2013) C. J. Desmet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

(2013) E. Ntantie et al.   Science Signaling

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma

(2013) Xiao-Xia Lu   WORLD JOURNAL OF GASTROENTEROLOGY

The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study

(2013) Geoff Bellingan et al.   Lancet Respiratory Medicine

Immunotherapeutic approaches in triple-negative breast cancer: latest research and clinical prospects

(2013) John Stagg et al.   Therapeutic Advances in Medical Oncology

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

(2012) H Wang et al.   BRITISH JOURNAL OF CANCER

NT5E CpG island methylation is a favourable breast cancer biomarker

(2012) C Lo Nigro et al.   BRITISH JOURNAL OF CANCER

CD73-Deficient Mice Are Resistant to Carcinogenesis

(2012) J. Stagg et al.   CANCER RESEARCH

Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer

(2012) Xiuling Zhi et al.   IUBMB LIFE

5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells

(2012) Claudia Quezada et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration

(2012) Hoon Kyu Oh et al.   Journal of Gynecologic Oncology

Tissue-Resident Ecto-5' Nucleotidase (CD73) Regulates Leukocyte Trafficking in the Ischemic Brain

(2012) D. Petrovic-Djergovic et al.   JOURNAL OF IMMUNOLOGY

Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma

(2012) G. Forte et al.   JOURNAL OF IMMUNOLOGY

Virtual Screening Identifies Novel Sulfonamide Inhibitors of ecto-5′-Nucleotidase

(2012) Peter Ripphausen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

(2012) Jens M. Poth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetic inactivation of the adenosine A2Areceptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis

(2012) Shu-Qin Yao et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis

(2012) Jeffrey H Mills et al.   Journal of Neuroinflammation

High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

(2012) Xian-Rui Wu et al.   JOURNAL OF SURGICAL ONCOLOGY

Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias

(2012) Deepesh P. Lad et al.   LEUKEMIA & LYMPHOMA

Autoimmunity in CD73/Ecto-5′-Nucleotidase Deficient Mice Induces Renal Injury

(2012) Cornelia Blume et al.   PLoS One

The P2X7 receptor is a key modulator of aerobic glycolysis

(2012) F Amoroso et al.   Cell Death & Disease

Different role of CD73 in leukocyte trafficking via blood and lymph vessels

(2011) A. Algars et al.   BLOOD

New markers for minimal residual disease detection in acute lymphoblastic leukemia

(2011) E. Coustan-Smith et al.   BLOOD

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

(2011) S. Serra et al.   BLOOD

EGFR gene copy number assessment from areas with highest EGFR expression predicts response to anti-EGFR therapy in colorectal cancer

(2011) A Ålgars et al.   BRITISH JOURNAL OF CANCER

Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

(2011) Adam T. Waickman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

(2011) J. Stagg et al.   CANCER RESEARCH

Altered purinergic signaling in CD73-deficient mice inhibits tumor progression

(2011) Gennady G. Yegutkin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

(2011) Long Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors

(2011) C. Cekic et al.   JOURNAL OF IMMUNOLOGY

Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier

(2011) A. J. Carman et al.   JOURNAL OF NEUROSCIENCE

Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

(2011) N. Sunaga et al.   MOLECULAR CANCER THERAPEUTICS

NT5EMutations and Arterial Calcifications

(2011) Cynthia St. Hilaire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

(2011) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human brain endothelial cells are responsive to adenosine receptor activation

(2011) Jeffrey H. Mills et al.   Purinergic Signalling

CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma

(2011) Anna Supernat et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (

(2010) G. Cancello et al.   ANNALS OF ONCOLOGY

Transfer of the glycosylphosphatidylinositol-anchored 5′-nucleotidase CD73 from adiposomes into rat adipocytes stimulates lipid synthesis

(2010) G Müller et al.   BRITISH JOURNAL OF PHARMACOLOGY

The prognostic contribution of clinical breast cancer subtype, age, and race among patients with breast cancer brain metastases

(2010) Carey K. Anders et al.   CANCER

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

CD73: A Novel Target for Cancer Immunotherapy

(2010) B. Zhang   CANCER RESEARCH

RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells

(2010) Xiuling Zhi et al.   CANCER SCIENCE

High expression and activity of ecto-5′-nucleotidase/CD73 in the male murine reproductive tract

(2010) Mireia Martín-Satué et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Adenosine and Prostaglandin E2Cooperate in the Suppression of Immune Responses Mediated by Adaptive Regulatory T Cells

(2010) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of Potent and Selective Inhibitors ofecto-5′-Nucleotidase Based on an Anthraquinone Scaffold

(2010) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats

(2009) Guo Qian Chen et al.   BRAIN RESEARCH

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

(2009) Celestia S. Higano et al.   CANCER

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Pattern of metastatic spread in triple-negative breast cancer

(2008) Rebecca Dent et al.   BREAST CANCER RESEARCH AND TREATMENT

IFN-β regulates CD73 and adenosine expression at the blood-brain barrier

(2008) Jussi Niemelä et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ecto-5′-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis

(2008) Zhongsheng Peng et al.   FASEB JOURNAL

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

(2008) Cornelia Liedtke et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation

(2008) Luci Bavaresco et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Quality of Life and Satisfaction with Outcome among Prostate-Cancer Survivors

(2008) Martin G. Sanda et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis

(2008) J. H. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA