Deficient primary cilia in obese adipose-derived mesenchymal stem cells: obesity, a secondary ciliopathy?

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

(2018) Adrian P. Mansini et al.   HEPATOLOGY

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

(2018) Jacqueline E. Siljee et al.   NATURE GENETICS

TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium

(2018) Michele A. Corrigan et al.   Scientific Reports

Primary Cilia Are Dysfunctional in Obese Adipose-Derived Mesenchymal Stem Cells

(2018) Andreas Ritter et al.   Stem Cell Reports

Primary cilia are sensors of electrical field stimulation to induce osteogenesis of human adipose-derived stem cells

(2017) Shaobo Cai et al.   FASEB JOURNAL

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule Motors Drive Hedgehog Signaling in Primary Cilia

(2017) Mu He et al.   TRENDS IN CELL BIOLOGY

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Neuronal control of peripheral insulin sensitivity and glucose metabolism

(2017) Johan Ruud et al.   Nature Communications

Obesity

(2017) Pedro González-Muniesa et al.   Nature Reviews Disease Primers

Stemness and Osteogenic and Adipogenic Potential are Differently Impaired in Subcutaneous and Visceral Adipose Derived Stem Cells (ASCs) Isolated from Obese Donors

(2017) L. De Girolamo et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The primary cilium is necessary for the differentiation and the maintenance of human adipose progenitors into myofibroblasts

(2017) N. Arrighi et al.   Scientific Reports

The role of primary cilia in obesity and diabetes

(2016) Francesco Volta et al.   Annals of the New York Academy of Sciences

Mechanisms of ciliogenesis suppression in dividing cells

(2016) Hidemasa Goto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy and primary cilia: dual interplay

(2016) Olatz Pampliega et al.   CURRENT OPINION IN CELL BIOLOGY

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway

(2016) Hironori Inaba et al.   JOURNAL OF CELL BIOLOGY

The Multifaceted Roles of Primary Cilia in the Regulation of Stem Cell Properties and Functions

(2016) Rui Lyu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

Cilium assembly and disassembly

(2016) Irma Sánchez et al.   NATURE CELL BIOLOGY

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Obesity-driven alterations in adipose-derived stem cells are partially restored by weight loss

(2016) Laura M. Pérez et al.   Obesity

Concise Review: Primary Cilia: Control Centers for Stem Cell Lineage Specification and Potential Targets for Cell-Based Therapies

(2016) Josephine C. Bodle et al.   STEM CELLS

Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells

(2016) Carolina Serena et al.   STEM CELLS

Human Adipose Stromal/Stem Cells from Obese Donors Show Reduced Efficacy in Halting Disease Progression in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

(2016) Amy L. Strong et al.   STEM CELLS

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal

(2016) Nur Hayati Jaafar Marican et al.   Stem Cell Reports

The primary cilium undergoes dynamic size modifications during adipocyte differentiation of human adipose stem cells

(2015) Nicolas Forcioli-Conti et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stress as a fundamental theme in cell plasticity

(2015) Ofer Shoshani et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Primary cilia in energy balance signaling and metabolic disorder

(2015) Hankyu Lee et al.   BMB Reports

Metabolic Regulation and Energy Homeostasis through the Primary Cilium

(2015) Edwin C. Oh et al.   Cell Metabolism

Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

(2015) Juan R. Acosta et al.   DIABETOLOGIA

Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome

(2015) Wilfredo Oliva-Olivera et al.   ENDOCRINOLOGY

Hypoxia Promotes the Inflammatory Response and Stemness Features in Visceral Fat Stem Cells From Obese Subjects

(2015) Elisa Petrangeli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity

(2015) Elise Jeffery et al.   NATURE CELL BIOLOGY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

(2015) Melis T. Dalbay et al.   STEM CELLS

Concise Review: The Obesity Cancer Paradigm: Exploration of the Interactions and Crosstalk with Adipose Stem Cells

(2015) Amy L. Strong et al.   STEM CELLS

Ciliary ectosomes: transmissions from the cell's antenna

(2015) Christopher R. Wood et al.   TRENDS IN CELL BIOLOGY

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

(2015) Sehyun Kim et al.   Nature Communications

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation

(2015) Tatsuo Miyamoto et al.   Cell Reports

Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem Cells from Obese Mouse and Human

(2015) Laura M. Pérez et al.   PLoS One

Bariatric surgery and diet-induced long-term caloric restriction protect subcutaneous adipose-derived stromal/progenitor cells and prolong their life span in formerly obese humans

(2014) Maria C. Mitterberger et al.   EXPERIMENTAL GERONTOLOGY

Leptin-promoted cilia assembly is critical for normal energy balance

(2014) Yu Mi Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Interplay between the immune system and adipose tissue in obesity

(2014) Mark A Exley et al.   JOURNAL OF ENDOCRINOLOGY

Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitro

(2014) Jia-Gui Huang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers

(2014) Ahmed Katsha et al.   Molecular Oncology

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Primary cilia are required in a unique subpopulation of neural progenitors

(2014) C. K. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents

(2014) Jantje M. Gerdes et al.   Nature Communications

HiJAK’d Signaling; the STAT3 Paradox in Senescence and Cancer Progression

(2014) Damian Junk et al.   Cancers

Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype

(2013) Blanca Oñate et al.   BMC GENOMICS

The Cilium Secretes Bioactive Ectosomes

(2013) Christopher R. Wood et al.   CURRENT BIOLOGY

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Primary Cilia: The Chemical Antenna Regulating Human Adipose-Derived Stem Cell Osteogenesis

(2013) Josephine C. Bodle et al.   PLoS One

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory Effects of Adipose-Derived Stem Cells: Fact or Fiction?

(2013) Angelo A. Leto Barone et al.   Biomed Research International

Obese-derived ASCs show impaired migration and angiogenesis properties

(2013) Laura M. Pérez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis

(2012) Shuying Yang et al.   BONE

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

(2012) Junmin Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Infusion of Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetic Rats: Identification of a Novel Role in Improving Insulin Sensitivity

(2012) Y. Si et al.   DIABETES

Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway

(2012) Kyung Ho Lee et al.   EMBO JOURNAL

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells

(2012) Akihito Inoko et al.   JOURNAL OF CELL BIOLOGY

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus

(2012) Muhammad Sajid Hamid Akash et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

(2012) Olga V. Plotnikova et al.   MOLECULAR BIOLOGY OF THE CELL

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Human adipose-derived cells: an update on the transition to clinical translation

(2012) Jeffrey M Gimble et al.   Regenerative Medicine

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Adipose tissue stem cells: the great WAT hope

(2012) William P. Cawthorn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Hedgehog signalling pathway regulates autophagy

(2012) Maria Jimenez-Sanchez et al.   Nature Communications

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells

(2011) Kazuya Sumi et al.   FEBS LETTERS

Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus

(2011) Franco Folli et al.   PLoS One

Human Adipose-Derived Stem Cells Impair Natural Killer Cell Function and Exhibit Low Susceptibility to Natural Killer-Mediated Lysis

(2011) Olga DelaRosa et al.   STEM CELLS AND DEVELOPMENT

The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment

(2010) Padmaja Tummala et al.   Cellular and Molecular Bioengineering

Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry

(2010) Doris Kinzel et al.   DEVELOPMENTAL CELL

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells

(2010) Rosa Yañez et al.   EXPERIMENTAL CELL RESEARCH

The Adipose-derived Stem Cell: Looking Back and Looking Ahead

(2010) Patricia A. Zuk   MOLECULAR BIOLOGY OF THE CELL

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis

(2009) E Gonzalez-Rey et al.   ANNALS OF THE RHEUMATIC DISEASES

The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

(2009) Jantje M. Gerdes et al.   CELL

Adipose Tissue Dysfunction in Obesity

(2009) M. Blüher   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation

(2009) C. A. Clement et al.   JOURNAL OF CELL SCIENCE

Can faulty antennae increase adiposity? The link between cilia proteins and obesity

(2009) Piya Sen Gupta et al.   JOURNAL OF ENDOCRINOLOGY

Mesenchymal stem cells from human bone marrow or adipose tissue differently modulate mitogen-stimulated B-cell immunoglobulin production in vitro

(2008) Ivan Bochev et al.   CELL BIOLOGY INTERNATIONAL

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery

(2008) Enko N. Kiprilov et al.   JOURNAL OF CELL BIOLOGY

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

(2008) Young-Goo Han et al.   NATURE NEUROSCIENCE

Activation of Hedgehog Signaling Inhibits Osteoblast Differentiation of Human Mesenchymal Stem Cells

(2008) Magali Plaisant et al.   STEM CELLS