Primary cilia in energy balance signaling and metabolic disorder

SnapShot: Sensing and Signaling by Cilia

(2015) Kurt Zimmerman et al.   CELL

Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity

(2014) Sophie Thomas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling

(2014) H. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morbid Obesity Resulting from Inactivation of the Ciliary Protein CEP19 in Humans and Mice

(2013) Adel Shalata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The primary cilium as a multiple cellular signaling scaffold in development and disease

(2012) Hyuk-Wan Ko   BMB Reports

BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and Decreased Inflammatory Response

(2012) Vincent Marion et al.   Cell Metabolism

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

(2012) Jeremy F Reiter et al.   EMBO REPORTS

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908

(2012) Di Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Alström Syndrome Protein, ALMS1, Interacts with α-Actinin and Components of the Endosome Recycling Pathway

(2012) Gayle B. Collin et al.   PLoS One

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

(2011) Liyun Sang et al.   CELL

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Functional modules, mutational load and human genetic disease

(2010) Norann A. Zaghloul et al.   TRENDS IN GENETICS

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Can faulty antennae increase adiposity? The link between cilia proteins and obesity

(2009) Piya Sen Gupta et al.   JOURNAL OF ENDOCRINOLOGY

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

(2008) Kamal Rahmouni et al.   JOURNAL OF CLINICAL INVESTIGATION

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA