Obesity and Type 2 Diabetes Alters the Immune Properties of Human Adipose Derived Stem Cells

Human Adipose Stromal/Stem Cells from Obese Donors Show Reduced Efficacy in Halting Disease Progression in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

(2016) Amy L. Strong et al.   STEM CELLS

Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue

(2016) Gisela Pachón-Peña et al.   Stem Cells Translational Medicine

Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

(2015) Assia Eljaafari et al.   DIABETES

Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype

(2015) Y-C Hwang et al.   INTERNATIONAL JOURNAL OF OBESITY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Mesenchymal Stromal Cells Affect Disease Outcomes via Macrophage Polarization

(2015) Guoping Zheng et al.   Stem Cells International

Obesity and weight loss could alter the properties of adipose stem cells?

(2015) Leandra S Baptista   World Journal of Stem Cells

Single cell-derived clones from human adipose stem cells present different immunomodulatory properties

(2014) J. M. Sempere et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of epigenetic mechanisms in the development of chronic complications of diabetes

(2014) Malgorzata Wegner et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype

(2013) Blanca Oñate et al.   BMC GENOMICS

Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue

(2013) Nathalie Esser et al.   DIABETOLOGIA

Epigenetics and Obesity: A Relationship Waiting to Be Explained

(2013) Michael E. Symonds et al.   HUMAN HEREDITY

Gene expression profiling in subcutaneous, visceral and epigastric adipose tissues of patients with extreme obesity

(2013) G S Gerhard et al.   INTERNATIONAL JOURNAL OF OBESITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

(2013) Sara M. Melief et al.   STEM CELLS

Body Fat Distribution and Insulin Resistance

(2013) Pavankumar Patel et al.   Nutrients

Adipose Tissue-Derived Multipotent Stromal Cells Have a Higher Immunomodulatory Capacity Than Their Bone Marrow-Derived Counterparts

(2013) Sara M. Melief et al.   Stem Cells Translational Medicine

Obese-derived ASCs show impaired migration and angiogenesis properties

(2013) Laura M. Pérez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

(2013) Ryan W. Grant et al.   Frontiers in Immunology

Cellular and molecular interactions of mesenchymal stem cells in innate immunity

(2012) Grazia Maria Spaggiari et al.   IMMUNOLOGY AND CELL BIOLOGY

Regulation of stem cell differentiation in adipose tissue by chronic inflammation

(2011) Jianping Ye et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

In vitromigration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors

(2011) Sun Jin Baek et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging

(2011) M. W. Maijenburg et al.   HAEMATOLOGICA

Is adipose tissue metabolically different at different sites?

(2011) Angel Gil et al.   International Journal of Pediatric Obesity

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Stromal stem cells from adipose tissue and bone marrow of age-matched female donors display distinct immunophenotypic profiles

(2010) G. Pachón-Peña et al.   JOURNAL OF CELLULAR PHYSIOLOGY

c-Jun N-Terminal Kinase 1/2 Activation by Tumor Necrosis Factor-α Induces Insulin Resistance In Human Visceral But Not Subcutaneous Adipocytes: Reversal by Liver X Receptor Agonists

(2009) Sonia Fernández-Veledo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Developmental Origin of Fat: Tracking Obesity to Its Source

(2008) Stephane Gesta et al.   CELL