HiJAK’d Signaling; the STAT3 Paradox in Senescence and Cancer Progression

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator

(2013) Philip Vlaicu et al.   BMC CANCER

Breast cancer statistics, 2013

(2013) Carol DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24

(2013) Allan Yi Liu et al.   CARCINOGENESIS

Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway

(2013) Jo Meagan Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial to Mesenchymal Transition Promotes Breast Cancer Progression via a Fibronectin-dependent STAT3 Signaling Pathway

(2013) Nikolas Balanis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer

(2013) N R West et al.   ONCOGENE

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

(2013) Seyung S. Chung et al.   PLoS One

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2

(2013) K H Koo et al.   Cell Death & Disease

System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity

(2013) Megha Rajaram et al.   PLoS Genetics

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Oncostatin M Is a Growth Factor for Ewing Sarcoma

(2012) Emmanuelle David et al.   AMERICAN JOURNAL OF PATHOLOGY

The metastatic niche and stromal progression

(2012) Jonathan P. Sleeman   CANCER AND METASTASIS REVIEWS

EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations

(2012) Jeremy Bastid   CANCER AND METASTASIS REVIEWS

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

Microenvironmental Regulation of Epithelial-Mesenchymal Transitions in Cancer

(2012) D. Gao et al.   CANCER RESEARCH

Epithelial-Stromal Interactions in Human Breast Cancer: Effects on Adhesion, Plasma Membrane Fluidity and Migration Speed and Directness

(2012) Cristiana Angelucci et al.   PLoS One

Senescence: a new weapon for cancer therapy

(2012) Juan Carlos Acosta et al.   TRENDS IN CELL BIOLOGY

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines

(2011) Kelly S. Levano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Unholy Trinity: Inflammation, Cytokines, and STAT3 Shape The Cancer Microenvironment

(2011) Ning Li et al.   CANCER CELL

c-MYC Functions as a Molecular Switch to Alter the Response of Human Mammary Epithelial Cells to Oncostatin M

(2011) C. E. Kan et al.   CANCER RESEARCH

Epithelial–mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact

(2011) Chiara Foroni et al.   CANCER TREATMENT REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

(2011) Michael K. Wendt et al.   CELL AND TISSUE RESEARCH

Oncogene-Induced Senescence and its Role in Tumor Suppression

(2011) Jay P. Reddy et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

(2011) Lars-Gunnar Larsson   SEMINARS IN CANCER BIOLOGY

A chemotherapy-associated senescence bystander effect in breast cancer cells

(2010) Xu Di et al.   CANCER BIOLOGY & THERAPY

Oncostatin M Renders Epithelial Cell Adhesion Molecule–Positive Liver Cancer Stem Cells Sensitive to 5-Fluorouracil by Inducing Hepatocytic Differentiation

(2010) Taro Yamashita et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Ras-Induced Senescence and its Physiological Relevance in Cancer

(2010) T. DiMauro et al.   CURRENT CANCER DRUG TARGETS

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microenvironmental Influences that Drive Progression from Benign Breast Disease to Invasive Breast Cancer

(2010) Magdalena A. Cichon et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Incidence of Precancerous Lesions in Breast Reduction Tissue: A Pathologic Review of 562 Consecutive Patients

(2010) Clancy J. Clark et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Mechanisms of Stem Cell Self-Renewal

(2009) He Shenghui et al.   Annual Review of Cell and Developmental Biology

OSM, LIF, Its Receptors, and Its Relationship with the Malignance in Human Breast Carcinoma (In Situand in Infiltrative)

(2008) Ignacio García-Tuñón et al.   CANCER INVESTIGATION

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Senescence: the good the bad and the dysfunctional

(2008) Ermira Pazolli et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis

(2008) Christine E. Eyler et al.   JOURNAL OF CLINICAL ONCOLOGY

Relationship between responsiveness of cancer cells to Oncostatin M and/or IL-6 and survival of stage III melanoma patients treated with tumour-infiltrating lymphocytes

(2008) A Lacreusette et al.   JOURNAL OF PATHOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-  and IL-6 signaling

(2008) Y. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA