Mechanisms of ciliogenesis suppression in dividing cells

Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation

(2016) Ji Hyun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanism of ciliary disassembly

(2016) Yinwen Liang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway

(2016) Hironori Inaba et al.   JOURNAL OF CELL BIOLOGY

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

Recycling endosomes

(2015) James R Goldenring   CURRENT OPINION IN CELL BIOLOGY

A Phosphoinositide Code for Primary Cilia

(2015) Fubito Nakatsu   DEVELOPMENTAL CELL

Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length

(2015) D. Maskey et al.   EMBO JOURNAL

New frontiers: discovering cilia-independent functions of cilia proteins

(2015) A. Vertii et al.   EMBO REPORTS

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

(2015) You Li et al.   NATURE

Molecular genetics and clinical features of Birt–Hogg–Dubé syndrome

(2015) Laura S. Schmidt et al.   Nature Reviews Urology

Post-translational modifications of tubulin: pathways to functional diversity of microtubules

(2015) Yuyu Song et al.   TRENDS IN CELL BIOLOGY

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

(2015) Sehyun Kim et al.   Nature Communications

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation

(2015) Tatsuo Miyamoto et al.   Cell Reports

Cilia and Diseases

(2014) Jason M. Brown et al.   BIOSCIENCE

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly

(2014) Tetsuo Kobayashi et al.   JOURNAL OF CELL BIOLOGY

Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis

(2014) R. M. Das et al.   SCIENCE

Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension

(2014) Kousuke Kasahara et al.   Nature Communications

Nephronophthisis-Associated CEP164 Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition

(2014) Gisela G. Slaats et al.   PLoS Genetics

VDAC3 and Mps1 negatively regulate ciliogenesis

(2013) Shubhra Majumder et al.   CELL CYCLE

Cell cycle progression by the repression of primary cilia formation in proliferating cells

(2013) Hidemasa Goto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Assembling a primary cilium

(2013) Sehyun Kim et al.   CURRENT OPINION IN CELL BIOLOGY

IGF-1 Activates a Cilium-Localized Noncanonical Gβγ Signaling Pathway that Regulates Cell-Cycle Progression

(2013) Celine Yeh et al.   DEVELOPMENTAL CELL

PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry

(2013) G. Wang et al.   JOURNAL OF CELL SCIENCE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Aurora A kinase (AURKA) in normal and pathological cell division

(2012) Anna S. Nikonova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Assembly and Persistence of Primary Cilia in Dividing Drosophila Spermatocytes

(2012) Maria Giovanna Riparbelli et al.   DEVELOPMENTAL CELL

Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway

(2012) Kyung Ho Lee et al.   EMBO JOURNAL

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells

(2012) Akihito Inoko et al.   JOURNAL OF CELL BIOLOGY

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

(2012) Olga V. Plotnikova et al.   MOLECULAR BIOLOGY OF THE CELL

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics

(2012) Jingli Cao et al.   NATURE CELL BIOLOGY

The Centrosomal Kinase Plk1 Localizes to the Transition Zone of Primary Cilia and Induces Phosphorylation of Nephrocystin-1

(2012) Tamina Seeger-Nukpezah et al.   PLoS One

Cilia and cell cycle re-entry

(2011) Sehyun Kim et al.   CELL CYCLE

Ndel1, Nudel ( Noodle): Flexible in the cell?

(2011) Mathieu Chansard et al.   Cytoskeleton

A role for Tctex-1 (DYNLT1) in controlling primary cilium length

(2011) Krysten J. Palmer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Regulating the transition from centriole to basal body

(2011) Tetsuo Kobayashi et al.   JOURNAL OF CELL BIOLOGY

Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome 1

(2011) C. A. M. Lopes et al.   JOURNAL OF CELL SCIENCE

Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein

(2011) M. Ibi et al.   JOURNAL OF CELL SCIENCE

Do cilia put brakes on the cell cycle?

(2011) Peter K. Jackson   NATURE CELL BIOLOGY

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

(2011) Aiqun Li et al.   NATURE CELL BIOLOGY

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

(2011) Sehyun Kim et al.   NATURE CELL BIOLOGY

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cilia in the CNS: The Quiet Organelle Claims Center Stage

(2011) Angeliki Louvi et al.   NEURON

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

The ciliary membrane

(2010) Rajat Rohatgi et al.   CURRENT OPINION IN CELL BIOLOGY

Ofd1, a Human Disease Gene, Regulates the Length and Distal Structure of Centrioles

(2010) Veena Singla et al.   DEVELOPMENTAL CELL

Pitchfork Regulates Primary Cilia Disassembly and Left-Right Asymmetry

(2010) Doris Kinzel et al.   DEVELOPMENTAL CELL

The perennial organelle: assembly and disassembly of the primary cilium

(2010) E. S. Seeley et al.   JOURNAL OF CELL SCIENCE

Novel CENPJ mutation causes Seckel syndrome

(2010) M. S. Al-Dosari et al.   JOURNAL OF MEDICAL GENETICS

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Lissencephaly: Mechanistic insights from animal models and potential therapeutic strategies

(2010) Anthony Wynshaw-Boris et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rapid calcium-dependent activation of Aurora-A kinase

(2010) Olga V. Plotnikova et al.   Nature Communications

The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis

(2010) Masami Yamada et al.   Cell Adhesion & Migration

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

(2009) Jantje M. Gerdes et al.   CELL

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

CPAP is a cell-cycle regulated protein that controls centriole length

(2009) Chieh-Ju C. Tang et al.   NATURE CELL BIOLOGY

Dual and opposing roles of primary cilia in medulloblastoma development

(2009) Young-Goo Han et al.   NATURE MEDICINE

Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis

(2009) Sunny Y Wong et al.   NATURE MEDICINE

Primary Cilia: Cellular Sensors for the Skeleton

(2008) Charles T. Anderson et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cell Cycle-Dependent Ciliogenesis and Cancer

(2008) O. V. Plotnikova et al.   CANCER RESEARCH

Polo and Aurora kinases—lessons derived from chemical biology

(2008) Stephen Taylor et al.   CURRENT OPINION IN CELL BIOLOGY

Assembly of primary cilia

(2008) Lotte B. Pedersen et al.   DEVELOPMENTAL DYNAMICS

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease

(2008) Julie A. Jonassen et al.   JOURNAL OF CELL BIOLOGY

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

(2008) Young-Goo Han et al.   NATURE NEUROSCIENCE