Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

Mechanistic Insights into the Bifunctional Non-Heme Iron Oxygenase Carbapenem Synthase by Active Site Saturation Mutagenesis

(2013) Ryan M. Phelan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A High-Throughput Screen for the Engineered Production of β-Lactam Antibiotics

(2012) Ryan M. Phelan et al.   ACS Chemical Biology

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

(2011) Refaat B. Hamed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective C–C bond formation catalysed by engineered carboxymethylproline synthases

(2011) Refaat B. Hamed et al.   Nature Chemistry

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

(2010) Refaat B. Hamed et al.   CHEMICAL COMMUNICATIONS

Synthesis and Conformational Analysis of Bicyclic Extended Dipeptide Surrogates

(2010) Sujeewa Ranatunga et al.   JOURNAL OF ORGANIC CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

(2009) Micah J. Bodner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular behavior of tauD provides insight into the origin of specificity in  -ketoglutarate-dependent nonheme iron oxygenases

(2009) K. P. McCusker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline

(2008) Refaat B. Hamed et al.   CHEMBIOCHEM