The Biosynthesis of Capuramycin-type Antibiotics

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine

(2015) Stéphane Cociancich et al.   Nature Chemical Biology

Biosynthesis of the Structurally Unique Polycyclopropanated Polyketide-Nucleoside Hybrid Jawsamycin (FR-900848)

(2014) Tomoshige Hiratsuka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

(2013) Masanori Funabashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Progress in targeting cell envelope biogenesis inMycobacterium tuberculosis

(2013) Mary Jackson et al.   Future Microbiology

Rising to the challenge: new therapies for tuberculosis

(2013) Emily B. Wong et al.   TRENDS IN MICROBIOLOGY

Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation

(2012) Gaiyun Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

(2012) Monica Mantri et al.   FEBS Journal

SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro

(2012) V. M. Reddy et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

(2012) Kun Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminoglycoside 2′′-Phosphotransferase IIIa (APH(2′′)-IIIa) Prefers GTP over ATP

(2012) Clyde A. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis: Discovery of an l-Threonine:Uridine-5′-Aldehyde Transaldolase

(2012) Sandra Barnard-Britson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage

(2012) Xiuling Chi et al.   MedChemComm

Identification of SQ609 as a lead compound from a library of dipiperidines

(2011) Elena Bogatcheva et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405

(2011) Yoko Fujita et al.   JOURNAL OF ANTIBIOTICS

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis

(2011) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

(2011) Xiuling Chi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207

(2010) V. M. Reddy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti-tuberculosis drug therapy in mice of different inbred strains

(2010) Boris V. Nikonenko et al.   INFECTION GENETICS AND EVOLUTION

The Actinomycin Biosynthetic Gene Cluster of Streptomyces chrysomallus: a Genetic Hall of Mirrors for Synthesis of a Molecule with Mirror Symmetry

(2010) U. Keller et al.   JOURNAL OF BACTERIOLOGY

Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics

(2010) Zhaoyong Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the genecluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471

(2010) Lin Cheng et al.   Molecular BioSystems

An ATP-independent strategy for amide bond formation in antibiotic biosynthesis

(2010) Masanori Funabashi et al.   Nature Chemical Biology

Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis

(2009) B. V. Nikonenko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation and characterization of pcsB, the gene for a polyene carboxamide synthase that tailors pimaricin into AB-400

(2009) Domingo Miranzo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis

(2009) Elena M. Seco et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Biosynthesis of Liposidomycin-like A-90289 Antibiotics Featuring a New Type of Sulfotransferase

(2009) Masanori Funabashi et al.   CHEMBIOCHEM

Analysis of the Liposidomycin Gene Cluster Leads to the Identification of New Caprazamycin Derivatives

(2009) Leonard Kaysser et al.   CHEMBIOCHEM

Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196

(2009) Masanori Funabashi et al.   JOURNAL OF ANTIBIOTICS

Identification and Manipulation of the Caprazamycin Gene Cluster Lead to New Simplified Liponucleoside Antibiotics and Give Insights into the Biosynthetic Pathway

(2009) Leonard Kaysser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2″-Phosphotransferases

(2009) Marta Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY