Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Aliphatic Halogenase Enables Late-Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity
Authors
Keywords
-
Journal
CHEMBIOCHEM
Volume 17, Issue 6, Pages 466-470
Publisher
Wiley
Online
2016-01-10
DOI
10.1002/cbic.201500674
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase
- (2016) Xinyu Liu et al. CHEMICAL COMMUNICATIONS
- The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
- (2016) Tim Cernak et al. CHEMICAL SOCIETY REVIEWS
- Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade
- (2015) Shasha Li et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Experimental Correlation of Substrate Position with Reaction Outcome in the Aliphatic Halogenase, SyrB2
- (2015) Ryan J. Martinie et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids
- (2015) Kuljira Ittiamornkul et al. Chemical Science
- More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme
- (2014) Sarah M. Pratter et al. CHEMBIOCHEM
- Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii
- (2014) Matthew L. Hillwig et al. CHEMBIOCHEM
- Expanding P450 catalytic reaction space through evolution and engineering
- (2014) John A McIntosh et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures
- (2014) Brandon R. Smith et al. JOURNAL OF MEDICINAL CHEMISTRY
- Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light
- (2014) Valerie A. Schmidt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A new family of iron-dependent halogenases acts on freestanding substrates
- (2014) Matthew L Hillwig et al. Nature Chemical Biology
- Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase
- (2014) Megan L Matthews et al. Nature Chemical Biology
- Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua
- (2013) Matthew L. Hillwig et al. ACS Chemical Biology
- Halogen Bond: Its Role beyond Drug–Target Binding Affinity for Drug Discovery and Development
- (2013) Zhijian Xu et al. Journal of Chemical Information and Modeling
- Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling
- (2013) Weerawat Runguphan et al. ORGANIC LETTERS
- Adding Aliphatic C-H Bond Oxidations to Synthesis
- (2012) M. C. White SCIENCE
- Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP
- (2011) Wei Jiang et al. BIOCHEMISTRY
- Gene Expression Enabling Synthetic Diversification of Natural Products: Chemogenetic Generation of Pacidamycin Analogs
- (2010) Abhijeet Deb Roy et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Manganese Porphyrins Catalyze Selective C−H Bond Halogenations
- (2010) Wei Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2
- (2009) Megan L. Matthews et al. BIOCHEMISTRY
- Metamorphic enzyme assembly in polyketide diversification
- (2009) Liangcai Gu et al. NATURE
- Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2
- (2009) M. L. Matthews et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biosynthesis of (−)-(1S,2R)-Allocoronamic Acyl Thioester by an FeII-Dependent Halogenase and a Cyclopropane-Forming Flavoprotein
- (2008) Christopher S. Neumann et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More