Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

(2018) Hsuan-Jen Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

(2018) Yu Nakashima et al.   Nature Communications

Insights into the unprecedented epoxidation mechanism of fumitremorgin B endoperoxidase (FtmOx1) from Aspergillus fumigatus by QM/MM calculations

(2017) Xiya Wang et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanistic insights into dioxygen activation, oxygen atom exchange and substrate epoxidation by AsqJ dioxygenase from quantum mechanical/molecular mechanical calculations

(2017) Xudan Song et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Mechanistic Insights into the Decoupled Desaturation and Epoxidation Catalyzed by Dioxygenase AsqJ Involved in the Biosynthesis of Quinolone Alkaloids

(2017) Hao Su et al.   ACS Catalysis

Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

(2016) Dorota Jakubczyk et al.   CHEMICAL COMMUNICATIONS

Unusual chemistries in fungal meroterpenoid biosynthesis

(2016) Yudai Matsuda et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovery of Key Dioxygenases that Diverged the Paraherquonin and Acetoxydehydroaustin Pathways in Penicillium brasilianum

(2016) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectroscopic Evidence for the Two C–H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

(2016) Esta Tamanaha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (−)-4′-Methoxycyclopenin Biosynthesis

(2016) Wei-chen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of fungal meroterpenoids

(2016) Yudai Matsuda et al.   NATURAL PRODUCT REPORTS

The molecular steps of citrinin biosynthesis in fungi

(2016) Yi He et al.   Chemical Science

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

(2015) Alois Bräuer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids

(2015) Yi Zou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme

(2015) Wupeng Yan et al.   NATURE

Non-Heme Dioxygenase Catalyzes Atypical Oxidations of 6,7-Bicyclic Systems To Form the 6,6-Quinolone Core of Viridicatin-Type Fungal Alkaloids

(2014) Noriyasu Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases

(2014) Hanna Tarhonskaya et al.   BIOCHEMISTRY

Complete Biosynthetic Pathway of Anditomin: Nature’s Sophisticated Synthetic Route to a Complex Fungal Meroterpenoid

(2014) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of the ergot alkaloids

(2014) Dorota Jakubczyk et al.   NATURAL PRODUCT REPORTS

Oxidative rearrangements during fungal biosynthesis

(2014) Russell Cox   NATURAL PRODUCT REPORTS

Cyclolization of D-Lysergic Acid Alkaloid Peptides

(2013) Judith Havemann et al.   CHEMISTRY & BIOLOGY

Chemical mechanisms involved during the biosynthesis of tropolones

(2013) Russell J Cox et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Spiro-Ring Formation is Catalyzed by a Multifunctional Dioxygenase in Austinol Biosynthesis

(2013) Yudai Matsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans

(2012) Hsien-Chun Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis

(2012) J. Davison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

(2011) Naoki Kato et al.   CHEMBIOCHEM

Reaction Coordinate of Isopenicillin N Synthase: Oxidase versus Oxygenase Activity

(2010) Christina D. Brown-Marshall et al.   BIOCHEMISTRY

Ergot alkaloids: structure diversity, biosynthetic gene clusters and functional proof of biosynthetic genes

(2010) Christiane Wallwey et al.   NATURAL PRODUCT REPORTS

Meroterpenoids produced by fungi

(2009) Regina Geris et al.   NATURAL PRODUCT REPORTS

FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

(2009) Nicola Steffan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Transition States in a Protein Environment − ONIOM QM:MM Modeling of Isopenicillin N Synthesis

(2008) Marcus Lundberg et al.   Journal of Chemical Theory and Computation

Evidence from Mechanistic Probes for Distinct Hydroperoxide Rearrangement Mechanisms in the Intradiol and Extradiol Catechol Dioxygenases

(2008) Meite Xin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Mechanism for Isopenicillin N Synthase from Density-Functional Modeling Highlights the Similarities with Other Enzymes in the 2-His-1-carboxylate Family†

(2007) Marcus Lundberg et al.   BIOCHEMISTRY