Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation

Mechanistic Insights into the Decoupled Desaturation and Epoxidation Catalyzed by Dioxygenase AsqJ Involved in the Biosynthesis of Quinolone Alkaloids

(2017) Hao Su et al.   ACS Catalysis

Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (−)-4′-Methoxycyclopenin Biosynthesis

(2016) Wei-chen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Chlorination of Substrates by the Halogenase SyrB2 Is Controlled by the Protein According to a Combined Quantum Mechanics/Molecular Mechanics and Molecular Dynamics Study

(2016) Jing Huang et al.   ACS Catalysis

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

(2015) Alois Bräuer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation?

(2015) Li Ji et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

(2015) Salette Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-Heme Dioxygenase Catalyzes Atypical Oxidations of 6,7-Bicyclic Systems To Form the 6,6-Quinolone Core of Viridicatin-Type Fungal Alkaloids

(2014) Noriyasu Ishikawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Insights into the Bifunctional Non-Heme Iron Oxygenase Carbapenem Synthase by Active Site Saturation Mutagenesis

(2013) Ryan M. Phelan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parallel and Competitive Pathways for Substrate Desaturation, Hydroxylation, and Radical Rearrangement by the Non-heme Diiron Hydroxylase AlkB

(2012) Harriet L. R. Cooper et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Does the TauD Enzyme Always Hydroxylate Alkanes, While an Analogous Synthetic Non-Heme Reagent Always Desaturates Them?

(2010) Dandamudi Usharani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Revealing the catalytic potential of an acyl-ACP desaturase: Tandem selective oxidation of saturated fatty acids

(2008) E. J. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA