Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer’s Disease

The Pancreas-Brain Axis: Insight into Disrupted Mechanisms Associating Type 2 Diabetes and Alzheimer's Disease

(2018) Gauri S. Desai et al.   JOURNAL OF ALZHEIMERS DISEASE

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking

(2017) Kaori Ito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

(2017) Lauren Macklin et al.   EXPERIMENTAL GERONTOLOGY

New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9

(2017) Elena Sánchez-López et al.   Nanomedicine-Nanotechnology Biology and Medicine

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Insulin potentiates the therapeutic effect of memantine against central STZ-induced spatial learning and memory deficit

(2016) Abbas Bahramian et al.   BEHAVIOURAL BRAIN RESEARCH

NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801

(2016) Hila Roshanravan et al.   DIABETES

IRS proteins and diabetic complications

(2016) Deborah P. Lavin et al.   DIABETOLOGIA

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

(2016) Eva Baquedano et al.   Disease Models & Mechanisms

Insulin Resistance and Neurodegeneration: Progress Towards the Development of New Therapeutics for Alzheimer’s Disease

(2016) Suzanne M. de la Monte   DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

(2016) Luca Troncone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Need for Better Diabetes Treatment: The Therapeutic Potential of NMDA Receptor Antagonists

(2016) A. Welters et al.   KLINISCHE PADIATRIE

Gender differences of peripheral plasma and liver metabolic profiling in APP/PS1 transgenic AD mice

(2016) Junfang Wu et al.   NEUROSCIENCE

Amantadine reduces glucagon and enhances insulin secretion throughout the oral glucose tolerance test: central plus peripheral nervous system mechanisms

(2016) Fuad Lechin   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

A Key Role of Insulin Receptors in Memory: Figure 1

(2015) Fernanda G. De Felice et al.   DIABETES

Effects of dextromethorphan as add-on to sitagliptin on blood glucose and serum insulin concentrations in individuals with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blinded, multiple crossover, single-dose clinical trial

(2015) J. Marquard et al.   DIABETES OBESITY & METABOLISM

Alzheimer-associated A  oligomers impact the central nervous system to induce peripheral metabolic deregulation

(2015) J. R. Clarke et al.   EMBO Molecular Medicine

Inhibitory Effect of Memantine on Streptozotocin-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Neurotrophic Factor Decline in Astrocytes

(2015) N. Rajasekar et al.   MOLECULAR NEUROBIOLOGY

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment

(2015) Jan Marquard et al.   NATURE MEDICINE

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

(2015) Claes B Wollheim et al.   NATURE MEDICINE

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Is Alzheimer's disease a systemic disease?

(2014) Jill K. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity

(2014) M. F. White   DIABETES OBESITY & METABOLISM

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC-fluorescence method

(2013) Mohamed G. Hassan et al.   BIOMEDICAL CHROMATOGRAPHY

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Amyloid-  Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

(2012) Y. Zhang et al.   DIABETES

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin resistance and AD—extending the translational path

(2012) Suzanne Craft   Nature Reviews Neurology

Can Alzheimer Disease Be a Form of Type 3 Diabetes?

(2012) Giulia Accardi et al.   REJUVENATION RESEARCH

Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

(2011) Helgi B. Schiöth et al.   MOLECULAR NEUROBIOLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

(2011) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling

(2011) Ángela M. Valverde et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH