Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment

(2015) Jan Marquard et al.   NATURE MEDICINE

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Inhibition of Pancreatic β-Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimulated Calcium Influx and Insulin Secretion, Impairing Glucose Tolerance

(2014) Prasanna K. Dadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion

(2014) Ghupurjan Gheni et al.   Cell Reports

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase

(2012) Laurène Vetterli et al.   MOLECULAR BIOLOGY OF THE CELL

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells

(2011) Nicole Feldmann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Calcineurin Signaling Regulates Human Islet β-Cell Survival

(2010) Scott A. Soleimanpour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Glutamate Is a Positive Autocrine Signal for Glucagon Release

(2008) Over Cabrera et al.   Cell Metabolism

Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators

(2008) M. Colella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA