Mechanisms underlying the role of DISC1 in synaptic plasticity

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

(2017) Antony S. K. Yerabham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

(2017) Gregg W. Crabtree et al.   JOURNAL OF NEUROSCIENCE

Regulation of mitochondrial dynamics by DISC1, a putative risk factor for major mental illness

(2017) Laura C. Murphy et al.   SCHIZOPHRENIA RESEARCH

NDE1 and GSK3β Associate with TRAK1 and Regulate Axonal Mitochondrial Motility: Identification of Cyclic AMP as a Novel Modulator of Axonal Mitochondrial Trafficking

(2016) Fumiaki Ogawa et al.   ACS Chemical Neuroscience

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

(2016) Kirsty F. Houslay et al.   BIOCHEMICAL JOURNAL

NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness

(2016) Nicholas J. Bradshaw et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

(2016) P-M Martin et al.   MOLECULAR PSYCHIATRY

Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits

(2016) S V Trossbach et al.   MOLECULAR PSYCHIATRY

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

(2016) Christian R Marshall et al.   NATURE GENETICS

Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits

(2016) Lin Cui et al.   Molecular Brain

Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring

(2016) Cana Park et al.   Molecular Brain

Proteostasis and RNA Binding Proteins in Synaptic Plasticity and in the Pathogenesis of Neuropsychiatric Disorders

(2016) Matthew E. Klein et al.   NEURAL PLASTICITY

Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro

(2016) D Tropea et al.   Translational Psychiatry

Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking

(2016) Eugenia Butkevich et al.   Scientific Reports

Mechanism and Regulation of Cytoplasmic Dynein

(2015) Michael A. Cianfrocco et al.   Annual Review of Cell and Developmental Biology

Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity

(2015) Jeremy Hall et al.   BIOLOGICAL PSYCHIATRY

Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats

(2015) Ya Miao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

(2015) Rosalind Norkett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons

(2015) Jing Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organization of TNIK in dendritic spines

(2015) Alain C. Burette et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Impermanence of dendritic spines in live adult CA1 hippocampus

(2015) Alessio Attardo et al.   NATURE

Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity

(2015) Daisuke Tsuboi et al.   NATURE NEUROSCIENCE

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

(2015) Alexander McGirr et al.   NEUROPSYCHOPHARMACOLOGY

Adult cortical plasticity depends on an early postnatal critical period

(2015) S. D. Greenhill et al.   SCIENCE

Neuronal migration abnormalities and its possible implications for schizophrenia

(2015) Kazue Muraki et al.   Frontiers in Neuroscience

The synapse in schizophrenia

(2014) Andrew J. Pocklington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1

(2014) Clair A. Booth et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amelioration of Diabetes-induced Cognitive Deficits by GSK-3β Inhibition is Attributed to Modulation of Neurotransmitters and Neuroinflammation

(2014) Ashok Kumar Datusalia et al.   MOLECULAR NEUROBIOLOGY

DISC1 regulates trafficking and processing of APP and Aβ generation

(2014) N Shahani et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain

(2013) Liang-Wen Juan et al.   Brain Structure & Function

Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour

(2013) Anamaria Sudarov et al.   EMBO Molecular Medicine

Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors

(2013) Olena A. Fedorenko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DISC1-related signaling pathways in adult neurogenesis of the hippocampus

(2013) Qian Wu et al.   GENE

DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking

(2013) Fumiaki Ogawa et al.   HUMAN MOLECULAR GENETICS

Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis

(2013) M. A. M. Franker et al.   JOURNAL OF CELL SCIENCE

The Role of GluA1 in Ocular Dominance Plasticity in the Mouse Visual Cortex

(2013) A. Ranson et al.   JOURNAL OF NEUROSCIENCE

A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons

(2013) A.M. Lepagnol-Bestel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

(2013) P A Thomson et al.   MOLECULAR PSYCHIATRY

Revisiting the TRAK Family of Proteins as Mediators of GABAA Receptor Trafficking

(2013) F. Anne Stephenson   NEUROCHEMICAL RESEARCH

Distinct Functions of Nuclear Distribution Proteins LIS1, Ndel1 and NudCL in Regulating Axonal Mitochondrial Transport

(2013) Chong-Yu Shao et al.   TRAFFIC

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription

(2012) Elise L.V. Malavasi et al.   HUMAN MOLECULAR GENETICS

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

(2012) Jennifer E. Eykelenboom et al.   HUMAN MOLECULAR GENETICS

Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport

(2012) Talia A. Atkin et al.   HUMAN MOLECULAR GENETICS

The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution

(2012) Dinesh C. Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity

(2012) A. Ranson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional transport of organelles: unity and struggle of opposing motors

(2011) Sofiya A. Bryantseva et al.   CELL BIOLOGY INTERNATIONAL

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

(2011) Keisuke Kuroda et al.   HUMAN MOLECULAR GENETICS

Molecular Characterization of Disrupted in Schizophrenia-1 Risk Variant S704C Reveals the Formation of Altered Oligomeric Assembly

(2011) Saravanakumar Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

(2011) H. Murdoch et al.   JOURNAL OF CELL SCIENCE

Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction

(2011) H. J. Carlisle et al.   JOURNAL OF NEUROSCIENCE

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

PKA Phosphorylation of NDE1 Is DISC1/PDE4 Dependent and Modulates Its Interaction with LIS1 and NDEL1

(2011) N. J. Bradshaw et al.   JOURNAL OF NEUROSCIENCE

Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)

(2011) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex

(2011) Tianyi Mao et al.   NEURON

Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice

(2011) Tatiana V. Lipina et al.   NEUROPHARMACOLOGY

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway

(2011) Rafael Flores et al.   NEUROSCIENCE RESEARCH

Phosphorylation of AMPA Receptors Is Required for Sensory Deprivation-Induced Homeostatic Synaptic Plasticity

(2011) Anubhuti Goel et al.   PLoS One

Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice

(2011) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice

(2011) Frankie H.F. Lee et al.   SCHIZOPHRENIA RESEARCH

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function

(2010) N. K. Hussain et al.   JOURNAL OF NEUROSCIENCE

Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

(2010) T. L. Young-Pearse et al.   JOURNAL OF NEUROSCIENCE

Structural Dynamics of Synapses in Vivo Correlate with Functional Changes during Experience-Dependent Plasticity in Visual Cortex

(2010) D. Tropea et al.   JOURNAL OF NEUROSCIENCE

Centrosome Motility Is Essential for Initial Axon Formation in the Neocortex

(2010) F. C. de Anda et al.   JOURNAL OF NEUROSCIENCE

DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth

(2010) T Hattori et al.   MOLECULAR PSYCHIATRY

Insoluble DISC1–Boymaw fusion proteins

(2010) X Zhou et al.   MOLECULAR PSYCHIATRY

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C

(2009) S. Rutger Leliveld et al.   BIOCHEMISTRY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

(2009) N. J. Brandon et al.   JOURNAL OF NEUROSCIENCE

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4

(2008) Atsushi Kamiya et al.   ARCHIVES OF GENERAL PSYCHIATRY

DISC1, PDE4B, and NDE1 at the centrosome and synapse

(2008) Nicholas J. Bradshaw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia

(2008) Wenjia Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

(2008) Daniel M. Collins et al.   CELLULAR SIGNALLING

UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly

(2008) H. Toda et al.   GENES & DEVELOPMENT

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

(2008) K. E. Burdick et al.   HUMAN MOLECULAR GENETICS

Ndel1 Controls the Dynein-mediated Transport of Vimentin during Neurite Outgrowth

(2008) Su Yeon Shim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertonia-Associated Protein Trak1 Is a Novel Regulator of Endosome-to-Lysosome Trafficking

(2008) Elizabeth Webber et al.   JOURNAL OF MOLECULAR BIOLOGY

SYNCRIP, a component of dendritically localized mRNPs, binds to the translation regulator BC200 RNA

(2008) Kerstin Duning et al.   JOURNAL OF NEUROCHEMISTRY

Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease

(2008) S. R. Leliveld et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic Action Potentials Are Required for Nitric-Oxide-Dependent Long-Term Potentiation in CA1 Neurons of Adult GluR1 Knock-Out and Wild-Type Mice

(2008) K. G. Phillips et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

(2008) N Sawamura et al.   MOLECULAR PSYCHIATRY

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

Sensory Deprivation Unmasks a PKA-Dependent Synaptic Plasticity Mechanism that Operates in Parallel with CaMKII

(2008) Neil Hardingham et al.   NEURON

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

(2008) Megumi Kaneko et al.   NEURON

NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

(2008) Nicholas J. Bradshaw et al.   NEUROSCIENCE LETTERS

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

(2008) A. C. Barbosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA