Proteostasis and RNA Binding Proteins in Synaptic Plasticity and in the Pathogenesis of Neuropsychiatric Disorders

TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration

(2015) Rosario Gulino et al.   CNS & Neurological Disorders-Drug Targets

Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD

(2015) Natasha M. Sosanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Glutamate Exposure Facilitates Group I mGluR-Mediated Epileptogenesis in the Hippocampus

(2015) W. Zhao et al.   JOURNAL OF NEUROSCIENCE

High-performance probes for light and electron microscopy

(2015) Sarada Viswanathan et al.   NATURE METHODS

Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity

(2015) Daisuke Tsuboi et al.   NATURE NEUROSCIENCE

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

(2015) Ju Huang et al.   NEURON

An RNA biosensor for imaging the first round of translation from single cells to living animals

(2015) J. M. Halstead et al.   SCIENCE

Single-molecule insights into mRNA dynamics in neurons

(2015) Adina R. Buxbaum et al.   TRENDS IN CELL BIOLOGY

Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD

(2015) Matthew E. Klein et al.   Cell Reports

Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease

(2015) Rosario Gulino et al.   Biomed Research International

Frontotemporal dementia: a bridge between dementia and neuromuscular disease

(2014) Adeline S.L. Ng et al.   Annals of the New York Academy of Sciences

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1

(2014) Takatoshi Iijima et al.   JOURNAL OF CELL BIOLOGY

Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome

(2014) Robert F Berman et al.   Journal of Neurodevelopmental Disorders

Selective Localization of Arc mRNA in Dendrites Involves Activity- and Translation-Dependent mRNA Degradation

(2014) S. Farris et al.   JOURNAL OF NEUROSCIENCE

GluA2 mRNA distribution and regulation by miR-124 in hippocampal neurons

(2014) Victoria M. Ho et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

In the right place at the right time: visualizing and understanding mRNA localization

(2014) Adina R. Buxbaum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic plasticity at the interface of health and disease: New insights on the role of endoplasmic reticulum intracellular calcium stores

(2014) N. Maggio et al.   NEUROSCIENCE

Mode division multiplexed optical transmission enabled by all–fiber mode multiplexer

(2014) Sun Hyok Chang et al.   OPTICS EXPRESS

Single  -Actin mRNA Detection in Neurons Reveals a Mechanism for Regulating Its Translatability

(2014) A. R. Buxbaum et al.   SCIENCE

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

(2014) Laurent Ferron et al.   Nature Communications

The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution

(2014) Nico P. Dantuma et al.   Frontiers in Molecular Neuroscience

Phosphorylation of Zipcode Binding Protein 1 Is Required for Brain-Derived Neurotrophic Factor Signaling of Local  -Actin Synthesis and Growth Cone Turning

(2013) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for Somatically and Dendritically Synthesized Brain-Derived Neurotrophic Factor in Morphogenesis of Dendritic Spines

(2013) L. L. Orefice et al.   JOURNAL OF NEUROSCIENCE

Glutamatergic Postsynaptic Density Protein Dysfunctions in Synaptic Plasticity and Dendritic Spines Morphology: Relevance to Schizophrenia and Other Behavioral Disorders Pathophysiology, and Implications for Novel Therapeutic Approaches

(2013) Andrea de Bartolomeis et al.   MOLECULAR NEUROBIOLOGY

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

(2013) Pan-Yue Deng et al.   NEURON

Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil

(2013) I. Epstein et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Subcellular RNA Sequencing Reveals Broad Presence of Cytoplasmic Intron-Sequence Retaining Transcripts in Mouse and Rat Neurons

(2013) Mugdha Khaladkar et al.   PLoS One

RNA-binding protein Sam68 controls synapse number and local  -actin mRNA metabolism in dendrites

(2013) M. E. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis

(2013) Mirela Spillane et al.   Cell Reports

Interactome of Two Diverse RNA Granules Links mRNA Localization to Translational Repression in Neurons

(2013) Renate Fritzsche et al.   Cell Reports

Cytoplasmic intron retention, function, splicing, and the sentinel RNA hypothesis

(2013) Peter T. Buckley et al.   Wiley Interdisciplinary Reviews-RNA

Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins

(2013) Amy W. Lin et al.   NEURAL PLASTICITY

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

 -Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration

(2012) Z. B. Katz et al.   GENES & DEVELOPMENT

RNA Binding Proteins Accumulate at the Postsynaptic Density with Synaptic Activity

(2012) G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium Channels

(2012) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation

(2012) V. C. Nalavadi et al.   JOURNAL OF NEUROSCIENCE

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Cis-Acting Polymorphisms Affect Complex Traits through Modifications of MicroRNA Regulation Pathways

(2012) Matthias Arnold et al.   PLoS One

Identification of a cis-acting element that localizes mRNA to synapses

(2012) E. J. Meer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal mRNAs travel singly into dendrites

(2012) M. Batish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage

(2011) Elias Pavlopoulos et al.   CELL

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1

(2011) Takatoshi Iijima et al.   CELL

Cyclin-Dependent Kinase 5 Regulates PSD-95 Ubiquitination in Neurons

(2011) M. J. Bianchetta et al.   JOURNAL OF NEUROSCIENCE

Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins

(2011) Lindsay A. Schwarz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Cytoplasmic Intron Sequence-Retaining Transcripts Can Be Dendritically Targeted via ID Element Retrotransposons

(2011) Peter T. Buckley et al.   NEURON

The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

(2011) Arvind Govindarajan et al.   NEURON

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

(2011) Hiroshi Makino et al.   NEURON

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

(2010) Chantal Sellier et al.   EMBO JOURNAL

Advances in understanding the molecular basis of FXTAS

(2010) D. Garcia-Arocena et al.   HUMAN MOLECULAR GENETICS

Arginylation Regulates Intracellular Actin Polymer Level by Modulating Actin Properties and Binding of Capping and Severing Proteins

(2010) Sougata Saha et al.   MOLECULAR BIOLOGY OF THE CELL

In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons

(2010) Daniela C Dieterich et al.   NATURE NEUROSCIENCE

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

(2010) Christian Lüscher et al.   NEURON

Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence-Dependent Degradation

(2010) F. Zhang et al.   SCIENCE

Disease-Associated Mutations That Alter the RNA Structural Ensemble

(2010) Matthew Halvorsen et al.   PLoS Genetics

N-methyl-d-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system

(2009) Ami Citri et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis

(2009) Maria Paola Paronetto et al.   JOURNAL OF CELL BIOLOGY

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Cytoplasmic Polyadenylation Element-Binding Protein Regulates Neurotrophin-3-Dependent  -Catenin mRNA Translation in Developing Hippocampal Neurons

(2009) M. Kundel et al.   JOURNAL OF NEUROSCIENCE

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity

(2009) D. O. Wang et al.   SCIENCE

Submicroscopic Duplications of the Hydroxysteroid Dehydrogenase HSD17B10 and the E3 Ubiquitin Ligase HUWE1 Are Associated with Mental Retardation

(2008) Guy Froyen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Motor coordination defects in mice deficient for the Sam68 RNA-binding protein

(2008) Kiven E. Lukong et al.   BEHAVIOURAL BRAIN RESEARCH

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Parkinson’s disease: A genetic perspective

(2008) Andrea C. Belin et al.   FEBS Journal

Zinc as a translation regulator in neurons: implications for P-body aggregation

(2008) J. Blumenthal et al.   JOURNAL OF CELL SCIENCE

Specific interaction between Sam68 and neuronal mRNAs: Implication for the activity-dependent biosynthesis of elongation factor eEF1A

(2008) Julien Grange et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis

(2008) G. Chawla et al.   MOLECULAR AND CELLULAR BIOLOGY

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

(2008) Min Li et al.   NATURE CELL BIOLOGY

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons

(2008) T. J. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA