Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

(2015) S.T. Masoud et al.   NEUROBIOLOGY OF DISEASE

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

(2014) D J Porteous et al.   MOLECULAR PSYCHIATRY

Direct and indirect pathways of basal ganglia: a critical reappraisal

(2014) Paolo Calabresi et al.   NATURE NEUROSCIENCE

Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene

(2014) Tsuyoshi Nakai et al.   NEUROCHEMISTRY INTERNATIONAL

A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects

(2014) Ping Su et al.   NEURON

Dopamine D2 Receptors Regulate the Anatomical and Functional Balance of Basal Ganglia Circuitry

(2014) Maxime Cazorla et al.   NEURON

Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models

(2014) Tatiana V. Lipina et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Systemic Amyloidoses

(2013) Luis M. Blancas-Mejía et al.   Annual Review of Biochemistry

Schizophrenia and dopamine receptors

(2013) Philip Seeman   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging

(2013) Hanna Jaaro-Peled et al.   HUMAN MOLECULAR GENETICS

Questions about DISC1 as a genetic risk factor for schizophrenia

(2013) P F Sullivan   MOLECULAR PSYCHIATRY

Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-Invasive Disrupted-In-Schizophrenia 1 Aggresomes

(2011) Philipp Ottis et al.   BIOLOGICAL PSYCHIATRY

Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions

(2011) Pierre F Durieux et al.   EMBO JOURNAL

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

(2011) Keisuke Kuroda et al.   HUMAN MOLECULAR GENETICS

Molecular Characterization of Disrupted in Schizophrenia-1 Risk Variant S704C Reveals the Formation of Altered Oligomeric Assembly

(2011) Saravanakumar Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model

(2011) Vladimir M. Pogorelov et al.   NEUROPHARMACOLOGY

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

(2011) A. J. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISCopathies: Brain Disorders Related to DISC1 Dysfunction

(2011) C. Korth   REVIEWS IN THE NEUROSCIENCES

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia

(2010) T. V. Lipina et al.   GENES BRAIN AND BEHAVIOR

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

(2010) Y Ayhan et al.   MOLECULAR PSYCHIATRY

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

(2010) Minae Niwa et al.   NEURON

A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia

(2010) Eleanor H. Simpson et al.   NEURON

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

(2010) S. Seshadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging

(2010) M. Johnstone et al.   SCHIZOPHRENIA BULLETIN

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C

(2009) S. Rutger Leliveld et al.   BIOCHEMISTRY

Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism

(2009) Eli C. Levin et al.   BRAIN RESEARCH

Effects of intranasally applied dopamine on behavioral asymmetries in rats with unilateral 6-hydroxydopamine lesions of the nigro-striatal tract

(2009) M.E. Pum et al.   NEUROSCIENCE

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

(2009) K. Nakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2Highreceptor

(2009) Philip Seeman et al.   SYNAPSE

Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1Highand D2Highreceptors in methamphetamine-sensitized rats

(2008) Takahide Shuto et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Schizophrenia as a progressive brain disease

(2008) N.E.M. van Haren et al.   EUROPEAN PSYCHIATRY

Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease

(2008) S. R. Leliveld et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Enlargement of the lateral ventricles in mutant DISC1 transgenic mice

(2008) M V Pletnikov et al.   MOLECULAR PSYCHIATRY

Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter

(2008) A. Salahpour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA