Linking neurodevelopmental and synaptic theories of mental illness through DISC1

Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-Invasive Disrupted-In-Schizophrenia 1 Aggresomes

(2011) Philipp Ottis et al.   BIOLOGICAL PSYCHIATRY

Neurodevelopmental hypothesis of schizophrenia

(2011) Michael J. Owen et al.   BRITISH JOURNAL OF PSYCHIATRY

Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development

(2011) Kenji Tomita et al.   HUMAN MOLECULAR GENETICS

NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1)

(2011) Takashi Namba et al.   JOURNAL OF NEUROCHEMISTRY

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

Association of white matter integrity with genetic variation in an exonic DISC1 SNP

(2011) E Sprooten et al.   MOLECULAR PSYCHIATRY

Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia

(2011) S M Brown et al.   MOLECULAR PSYCHIATRY

Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling

(2011) B C Carlyle et al.   MOLECULAR PSYCHIATRY

Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

(2011) C-H Chiang et al.   MOLECULAR PSYCHIATRY

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

(2011) Koko Ishizuka et al.   NATURE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

DISC1 is associated with cortical thickness and neural efficiency

(2011) Stefan Brauns et al.   NEUROIMAGE

DISC1 and Huntington's Disease – Overlapping Pathways of Vulnerability to Neurological Disorder?

(2011) Ruth Boxall et al.   PLoS One

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling

(2011) S.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

(2011) A. J. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Data of Diagnosis: New Approaches to Psychiatric Classification

(2011) Bruce Cuthbert et al.   PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES

Schizophrenia Genetics: Where Next?

(2011) Y. Kim et al.   SCHIZOPHRENIA BULLETIN

The Hippocampal Formation in Schizophrenia

(2010) Carol A. Tamminga et al.   AMERICAN JOURNAL OF PSYCHIATRY

Rodent models in depression research: Classical strategies and new directions

(2010) Daniela D. Pollak et al.   ANNALS OF MEDICINE

Ubiquitination in Postsynaptic Function and Plasticity

(2010) Angela M. Mabb et al.   Annual Review of Cell and Developmental Biology

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi

(2010) Ken-ichiro Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

(2010) Bagrat Abazyan et al.   BIOLOGICAL PSYCHIATRY

Genome-Wide Association Study of Schizophrenia in a Japanese Population

(2010) Masashi Ikeda et al.   BIOLOGICAL PSYCHIATRY

The ubiquitin E3 ligase Nedd4-1 controls neurite development

(2010) Hiroshi Kawabe et al.   CELL CYCLE

Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses

(2010) Andrew F. MacAskill et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era

(2010) Noah S Philip et al.   EXPERT OPINION ON PHARMACOTHERAPY

Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia

(2010) T. V. Lipina et al.   GENES BRAIN AND BEHAVIOR

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain

(2010) S. L. Eastwood et al.   HUMAN MOLECULAR GENETICS

CAMDI, a Novel Disrupted in Schizophrenia 1 (DISC1)-binding Protein, Is Required for Radial Migration

(2010) Toshifumi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function

(2010) N. K. Hussain et al.   JOURNAL OF NEUROSCIENCE

Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

(2010) T. L. Young-Pearse et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth

(2010) Mirian A.F. Hayashi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons

(2010) T A Atkin et al.   MOLECULAR PSYCHIATRY

Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents

(2010) A Raznahan et al.   MOLECULAR PSYCHIATRY

DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth

(2010) T Hattori et al.   MOLECULAR PSYCHIATRY

Insoluble DISC1–Boymaw fusion proteins

(2010) X Zhou et al.   MOLECULAR PSYCHIATRY

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

(2010) Y Ayhan et al.   MOLECULAR PSYCHIATRY

Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation

(2010) H Ito et al.   MOLECULAR PSYCHIATRY

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Dixdc1 Is a Critical Regulator of DISC1 and Embryonic Cortical Development

(2010) Karun K. Singh et al.   NEURON

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

(2010) Minae Niwa et al.   NEURON

Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder

(2010) Wenjia Song et al.   NEUROSCIENCE LETTERS

Adolescent Maturation of Cortical Dopamine

(2010) Patricio O’Donnell   NEUROTOXICITY RESEARCH

Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

(2010) S. Seshadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted-in-schizophrenia1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin

(2010) Young-Un Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging

(2010) M. Johnstone et al.   SCHIZOPHRENIA BULLETIN

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3

(2010) Tatiana V. Lipina et al.   SYNAPSE

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Meta-analytic Evidence for Familial Coaggregation of Schizophrenia and Bipolar Disorder

(2009) Jared X. Van Snellenberg et al.   ARCHIVES OF GENERAL PSYCHIATRY

Association of Variants in DISC1 With Psychosis-Related Traits in a Large Population Cohort

(2009) Liisa Tomppo et al.   ARCHIVES OF GENERAL PSYCHIATRY

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood

(2009) Daisuke Ibi et al.   BEHAVIOURAL BRAIN RESEARCH

Schizophrenia genetics: new insights from new approaches

(2009) H. J. Williams et al.   BRITISH MEDICAL BULLETIN

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation

(2009) C. M. Drerup et al.   DEVELOPMENT

Disc1 regulates granule cell migration in the developing hippocampus

(2009) Kate D. Meyer et al.   HUMAN MOLECULAR GENETICS

Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

(2009) N. J. Brandon et al.   JOURNAL OF NEUROSCIENCE

DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release

(2009) S L Eastwood et al.   MOLECULAR PSYCHIATRY

Molecular genetics and imaging technologies for circuit-based neuroanatomy

(2009) Benjamin R. Arenkiel et al.   NATURE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia

(2009) Ignacio Mata et al.   NEUROIMAGE

AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis

(2009) Hiroshi Makino et al.   NEURON

DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

(2009) Ju Young Kim et al.   NEURON

Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus

(2009) Atsushi Enomoto et al.   NEURON

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

(2009) K. Nakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

(2009) M. E. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia

(2009) Tsutomu Takahashi et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models

(2009) Hanna Jaaro-Peled et al.   SCHIZOPHRENIA BULLETIN

Psychosocial Treatments to Promote Functional Recovery in Schizophrenia

(2009) R. S. Kern et al.   SCHIZOPHRENIA BULLETIN

The Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis

(2009) D. K. Dickman et al.   SCIENCE

Control of mitochondrial transport and localization in neurons

(2009) Andrew F. MacAskill et al.   TRENDS IN CELL BIOLOGY

Copy-number variants in neurodevelopmental disorders: promises and challenges

(2009) Alison K. Merikangas et al.   TRENDS IN GENETICS

Modeling cognitive endophenotypes of schizophrenia in mice

(2009) Christoph Kellendonk et al.   TRENDS IN NEUROSCIENCES

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1

(2009) Hanna Jaaro-Peled et al.   TRENDS IN NEUROSCIENCES

Recruitment of PCM1 to the Centrosome by the Cooperative Action of DISC1 and BBS4

(2008) Atsushi Kamiya et al.   ARCHIVES OF GENERAL PSYCHIATRY

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia

(2008) Wenjia Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative Risk for Harms of Second-Generation Antidepressants

(2008) Gerald Gartlehner et al.   DRUG SAFETY

Association of the Ser704Cys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding

(2008) Annabella Di Giorgio et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus

(2008) Kate D. Meyer et al.   GENE EXPRESSION PATTERNS

Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain

(2008) Jonathan D. Wood et al.   HUMAN MOLECULAR GENETICS

Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease

(2008) S. R. Leliveld et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

(2008) N Sawamura et al.   MOLECULAR PSYCHIATRY

Does disrupted-in-schizophrenia (DISC1) generate fusion transcripts?

(2008) X Zhou et al.   MOLECULAR PSYCHIATRY

Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function

(2008) D P Prata et al.   MOLECULAR PSYCHIATRY

A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia

(2008) S R Datta et al.   MOLECULAR PSYCHIATRY

The dystrobrevin-binding protein 1 gene: features and networks

(2008) A Y Guo et al.   MOLECULAR PSYCHIATRY

Identification of loci associated with schizophrenia by genome-wide association and follow-up

(2008) Michael C O'Donovan et al.   NATURE GENETICS

Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain

(2008) R. L. Faulkner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype

(2008) Steven G. Potkin et al.   SCHIZOPHRENIA BULLETIN

Convergent CaMK and RacGEF signals control dendritic structure and function

(2008) Peter Penzes et al.   TRENDS IN CELL BIOLOGY

Dendritic spine dynamics – a key role for kalirin-7

(2008) Peter Penzes et al.   TRENDS IN NEUROSCIENCES

Disrupted-in-Schizophrenia-1

(2008) Walter J. Muir et al.   Current Psychiatry Reports

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia

(2007) Philip R. Szeszko et al.   BIOLOGICAL PSYCHOLOGY

How has DISC1 enabled drug discovery?

(2007) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE