708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

The DISC1 promoter: characterization and regulation by FOXP2

(2012) Rosie M. Walker et al.   HUMAN MOLECULAR GENETICS

DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription

(2012) Elise L.V. Malavasi et al.   HUMAN MOLECULAR GENETICS

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

(2012) Jennifer E. Eykelenboom et al.   HUMAN MOLECULAR GENETICS

The severity of mental disorders is linked to interaction among candidate genes

(2012) Basant K. Tiwary   Integrative Biology

Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression

(2012) P A Thomson et al.   MOLECULAR PSYCHIATRY

Deep resequencing and association analysis of schizophrenia candidate genes

(2012) J J Crowley et al.   MOLECULAR PSYCHIATRY

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

(2012) M Ayalew et al.   MOLECULAR PSYCHIATRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia

(2012) Peilin Jia et al.   PLoS Computational Biology

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

(2011) Dinesh C. Soares et al.   ACS Chemical Neuroscience

Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene

(2011) Nathan Osbun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls

(2011) E.K. Green et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia

(2011) I Mathieson et al.   MOLECULAR PSYCHIATRY

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes

(2011) M A Carless et al.   MOLECULAR PSYCHIATRY

Genome-wide association studies establish that human intelligence is highly heritable and polygenic

(2011) G Davies et al.   MOLECULAR PSYCHIATRY

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population

(2011) Lotte N. Moens et al.   PLoS One

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

The P-value illusion: How to improve (psychiatric) genetic studies

(2010) Alexander B. Niculescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Severe Mental Disorders in Offspring With 2 Psychiatrically Ill Parents

(2010) Irving I. Gottesman et al.   ARCHIVES OF GENERAL PSYCHIATRY

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain

(2010) S. L. Eastwood et al.   HUMAN MOLECULAR GENETICS

Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons

(2010) T A Atkin et al.   MOLECULAR PSYCHIATRY

Insoluble DISC1–Boymaw fusion proteins

(2010) X Zhou et al.   MOLECULAR PSYCHIATRY

Genome-wide association study of major depressive disorder: new results, meta-analysis and lessons learned

(2010) N R Wray et al.   MOLECULAR PSYCHIATRY

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder

(2010) Wenjia Song et al.   NEUROSCIENCE LETTERS

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging

(2010) M. Johnstone et al.   SCHIZOPHRENIA BULLETIN

A 1q42 deletion involvingDISC1,DISC2, andTSNAXin an autism spectrum disorder

(2009) Jaime M. Williams et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C

(2009) S. Rutger Leliveld et al.   BIOCHEMISTRY

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release

(2009) S L Eastwood et al.   MOLECULAR PSYCHIATRY

The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes

(2009) William Hennah et al.   PLoS One

Convergent functional genomics of genome-wide association data for bipolar disorder: Comprehensive identification of candidate genes, pathways and mechanisms

(2008) H. Le-Niculescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia

(2008) Wenjia Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms

(2008) C. Chelala et al.   BIOINFORMATICS

Mapping short DNA sequencing reads and calling variants using mapping quality scores

(2008) H. Li et al.   GENOME RESEARCH

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding

(2008) K. E. Burdick et al.   HUMAN MOLECULAR GENETICS

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

(2008) N Sawamura et al.   MOLECULAR PSYCHIATRY

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

(2008) W Hennah et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

(2008) M Y M Ng et al.   MOLECULAR PSYCHIATRY