Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 523, Issue 13, Pages 1913-1924Publisher
WILEY-BLACKWELL
DOI: 10.1002/cne.23770
Keywords
TNIK; dendritic spine; PSD; cerebral cortex; striatum RRID:AB_11212843; RRID:AB_1858225; RRID:AB_11213019; RRID:nif-0000-30467; RRID:AB_94396
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Funding
- Pfizer
- National Institutes of Health [R01 NS039444]
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Tumor necrosis factor receptor-associated factor 2 (TRAF2)- and noncatalytic region of tyrosine kinase (NCK)-interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high-resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling. J. Comp. Neurol. 523:1913-1924, 2015 (C) 2015 Wiley Periodicals, Inc.
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